Results 141 to 150 of about 400,342 (335)

Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver Metastases

Advanced Science, EarlyView.
This study synthesized a personalized neoantigen vaccine (Neo‐CRCVAS) and combined it with regorafenib, termed RegoNeo. This combination therapy significantly enhanced antitumor efficacy and promoted long‐term tumor‐specific immune memory in microsatellite stable colorectal cancer liver metastasis (MSS‐CRLM) models by increasing neoantigen‐specific ...
Hengkai Chen, Bin Chen, Yuanfeng Yang, Shoufeng Li, Huajun Cai, Zhicheng Zhuang, Yong Wu, Yuan Gao, Yupeng Chen, Xing Liu, Guoxian Guan, Jinfu Zhuang   +11 more
wiley   +1 more source

Treatment for hepatocellular carcinoma (HCC) with esophageal varices.

, 1985
Kuniaki Kojima, Koichi OKUYAMA, Shinsuke Oura, Takashi Hanzawa, Eiichi Kinoshita, Masaki Fukasawa, Shunji Futagawa, Mitsuo Sugiura   +7 more
openalex   +2 more sources

Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation

Advanced Science, EarlyView.
A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo, Huang Yang, Xiaoming Jiang, Zheng Wang, Xuxiao He, Ying Meng, Shan Li, Min Li, Daqian Xu, Zhengwei Mao, Zhimin Lu   +10 more
wiley   +1 more source

Investigation of serum Cu, Zn-SOD concentration by ELISA and histological localization in hepatocellular carcinoma(HCC), liver cirrhosis(LC), and alcoholic liver injury using anti-human Cu, Zn-SOD monoclonal antibody.

, 1987
Isao Sakaida
openalex   +2 more sources

The paradox of immunotherapy in NASH-HCC [PDF]

Signal Transduction and Targeted Therapy, 2021
Jun Yu, Jun Yu, Yao Peng, Yao Peng, Chi Chun Wong   +4 more
openaire   +4 more sources

The microenvironment in the development of MASLD-MASH-HCC and associated therapeutic in MASH-HCC

Frontiers in Immunology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a series of obesity-related metabolic liver diseases, ranging from relatively benign hepatic steatosis to metabolic-associated steatohepatitis (MASH). With the changes in lifestyle, its incidence and prevalence have risen to epidemic proportions globally. In recent years, an increasing
Qiulin Wu, Yan Yang, Shixun Lin, David A. Geller, Yihe Yan   +4 more
openaire   +3 more sources

Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation

Advanced Science, EarlyView.
The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng, Željko Janićijević, Liliana R. Loureiro, Lydia Hoffmann, Poh Soo Lee, Isli Cela, Benjamin Kruppke, Alexandra Kegler, Anja Feldmann, Ielizaveta Gorodetska, Anja Madleine Markl, Anna Dubrovska, Anne Kathrin Offermann, Michael Bachmann, Larysa Baraban   +14 more
wiley   +1 more source

mRECIST for HCC: Performance and novel refinements.

Journal of Hepatology, 2020
J. Llovet, R. Lencioni
semanticscholar   +1 more source

Pathomorphological study on resected hepatocellular carcinoma (HCC). Relationship between gross type and recurrence in resected HCC smaller than 3cm in diameter.

, 1989
Kazumitsu Kiyomatsu, Osamu Nakashima, Shigetaka Sugihara, Masamichi Kojiro, Satoshi Taniwaki, Hirotomo Saitsu, Toshimichi Nakayama   +6 more
openalex   +2 more sources

HCC, diet and metabolic factors: Diet and HCC.

Hepatitis monthly, 2011
Hepatocellular carcinoma is the most common primary liver malignancy and is an international public health concern, constituting one of the most deadly cancers worldwide. Infection with hepatitis B virus and hepatitis C virus is a major risk factor for HCC in developed countries.
Maurizio, Montella, Anna, Crispo, Aldo, Giudice   +2 more
openaire   +1 more source