Results 51 to 60 of about 160,497 (241)
Cancer Management and Research, 2020 Khaled Abouelezz,1 Dipen Khanapara,1 Gaber El-Saber Batiha,2 Esraa A Ahmed,3,4 Helal F Hetta1,5 1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA; 2Department of Pharmacology and Therapeutics, Faculty of ...
Abouelezz K +4 more
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Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao +18 more
wiley +1 more source
Circulating miR-210 and miR-1246 as potential biomarkers for differentiating hepatocellular carcinoma from metastatic tumors in the liver [PDF]
Journal of Medical Biochemistry, 2019 Background: To date few reports have pointed out the role of circulating miRNAs in discriminating metastatic liver tumors from primary hepatocellular (HCC) tumors. Such discrimination will have significant therapeutic and prognostic implications.
Ahmed Emad K. +3 more
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Advanced Science, EarlyView.We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li +10 more
wiley +1 more source
Journal of Hepatocellular Carcinoma, 2021 Francesca Fornari,1,2 Catia Giovannini,1,3 Fabio Piscaglia,4,5 Laura Gramantieri4 1Centre for Applied Biomedical Research - CRBA, University of Bologna, St.
Fornari F +3 more
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Advanced Science, EarlyView.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source
Journal of Hepatocellular Carcinoma, 2021 Wei-Chou Chang,1 Hsian-He Hsu,1 Sung-Hua Chiu,1 Wen-Yen Huang,2 Cheng-Hsiang Lo,2 Hsuan-Hwai Lin,3 Pei-Ching Huang,4 Yu-Lueng Shih,3 Yung-Liang Wan4 1Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei ...
Chang WC +8 more
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Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression
Advanced Science, EarlyView.Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang +11 more
wiley +1 more source
Clinical and Experimental Gastroenterology, 2019 Wei Hou,1,2 Kunyan Qiao,1 Zhixiao Huo,1 Yanan Du,3 Cindy Wang,2 Wing-Kin Syn2,4 1Tianjin Second People’s Hospital and Tianjin Institute of Hepatology, Tianjin, People’s Republic of China; 2Division of Gastroenterology and Hepatology ...
Hou W +5 more
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