Results 1 to 10 of about 21,262 (243)

HDAC4: an emerging target in diabetes mellitus and diabetic complications [PDF]

European Journal of Medical Research
Diabetes mellitus (DM) is a metabolic disease with complex pathogenic mechanisms. Histone deacetylase 4 (HDAC4) is a member of an important family of epigenetic modifications.
Yiqi Lin, Yuetong Li, Caiying Ke, Ying Jin, Wanwen Lao, Yiling Wu, Yang Liu, Xinyi Kong, Jie Qiao, Aixia Zhai, Changlong Bi   +10 more
doaj   +3 more sources

Seneca Valley virus 3C protease cleaves HDAC4 to antagonize type I interferon signaling [PDF]

Journal of Virology
Seneca Valley virus (SVV) is a newly identified pathogen that poses a notable threat to the global pig industry. SVV has evolved multiple strategies to evade host antiviral innate immune responses.
Zijian Li, Jingjing Yang, Ruiyi Ma, Shijie Xie, Dan Wang, Rong Quan, Xuexia Wen, Jue Liu, Jiangwei Song   +8 more
doaj   +3 more sources

HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes [PDF]

Scientific Reports, 2018
Skeletal muscle exhibits a high regenerative capacity, mainly due to the ability of satellite cells to replicate and differentiate in response to appropriate stimuli. Epigenetic control is effective at different stages of this process.
Nicoletta Marroncelli, Marzia Bianchi, Marco Bertin, Silvia Consalvi, Valentina Saccone, Marco De Bardi, Pier Lorenzo Puri, Daniela Palacios, Sergio Adamo, Viviana Moresi   +9 more
doaj   +3 more sources

HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses [PDF]

Skeletal Muscle, 2018
Background Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy.
Eva Pigna, Alessandra Renzini, Emanuela Greco, Elena Simonazzi, Stefania Fulle, Rosa Mancinelli, Viviana Moresi, Sergio Adamo   +7 more
doaj   +3 more sources

Upregulated ribosome pathway plays a key role in HDAC4, improving the survival rate and biofunction of chondrocytes

Bone & Joint Research, 2023
Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes.
Li Guo, Hua Guo, Yuanyu Zhang, Zhi Chen, Jian Sun, Gaige Wu, Yunfei Wang, Yang Zhang, Xiaochun Wei, Pengcui Li   +9 more
doaj   +2 more sources

N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in Drosophila [PDF]

Open Biology
Histone deacetylase four (HDAC4) undergoes dynamic nucleocytoplasmic shuttling, a process critical for regulating its activity. However, aberrant nuclear accumulation of HDAC4 is associated with both neurodevelopmental and neurodegenerative disease, and ...
Hannah R. Hawley, Andrew J. Sutherland-Smith, Matthew S. Savoian, Helen L. Fitzsimons   +3 more
doaj   +2 more sources

HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target

Cell Death and Disease, 2021
Histone deacetylases (HDACs) are involved in tumor progression, and some have been successfully targeted for cancer therapy. The expression of histone deacetylase 4 (HDAC4), a class IIa HDAC, was upregulated in our previous microarray screen.
Chun Cheng, Jun Yang, Si-Wei Li, Guofu Huang, Chenxi Li, Wei-Ping Min, Yi Sang   +6 more
doaj   +2 more sources

HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model

BMC Musculoskeletal Disorders
Background The present study evaluated whether the lack of histone deacetylase 4 (HDAC4) increases endoplasmic reticulum stress-induced chondrocyte apoptosis by releasing activating transcription factor 4 (ATF4) in human osteoarthritis (OA) cartilage ...
Xiaodong Gu, Fei Li, Xianda Che, Xiaochun Wei, Pengcui Li   +4 more
doaj   +2 more sources

Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions have never been ...
Alessandra Renzini, Nicoletta Marroncelli, Giorgia Cavioli, Silvia Di Francescantonio, Laura Forcina, Alessandro Lambridis, Eros Di Giorgio, Sergio Valente, Antonello Mai, Claudio Brancolini, Claudia Giampietri, Alessandra Magenta, Francesca De Santa, Sergio Adamo, Dario Coletti, Viviana Moresi   +15 more
doaj   +2 more sources

Increased Abundance of Nuclear HDAC4 Impairs Neuronal Development and Long-Term Memory

Frontiers in Molecular Neuroscience, 2021
Dysregulation of the histone deacetylase HDAC4 is associated with both neurodevelopmental and neurodegenerative disorders, and a feature common to many of these disorders is impaired cognitive function. HDAC4 shuttles between the nucleus and cytoplasm in
Patrick Main, Wei Jun Tan, David Wheeler, Helen L. Fitzsimons   +3 more
doaj   +1 more source