Results 111 to 120 of about 21,262 (243)

HDAC4-Regulated STAT1 Activation Mediates Platinum Resistance in Ovarian Cancer [PDF]

Cancer Research, 2011
Abstract Ovarian cancer frequently acquires resistance to platinum chemotherapy, representing a major challenge for improving patient survival. Recent work suggests that resistant clones exist within a larger drug-sensitive cell population prior to chemotherapy, implying that resistance is selected for rather than generated by ...
Stronach, Euan A, Alfraidi, Albandri, Rama, Nona, Datler, Christoph, Studd, James B., Agarwal, Roshan, Guney, Tankut G., Gourley, Charlie, Hennessy, Bryan T., Mills, Gordon B., MAI, Antonello, Brown, Robert, Dina, Roberto, Gabra, Hani   +13 more
openaire   +3 more sources

Interfering histone deacetylase 4 inhibits the proliferation of vascular smooth muscle cells via regulating MEG3/miR-125a-5p/IRF1

Cell Adhesion & Migration, 2019
In this study, we investigated the role ofhistone deacetylase 4 (HDAC4) and MEG3/miR-125a-5p/interferonregulatoryfactor 1 (IRF1) on vascular smooth muscle cell (VSMCs)proliferation.
Xiangtao Zheng, Ziheng Wu, Ke Xu, Yihui Qiu, Xiang Su, Zhen Zhang, Mengtao Zhou   +6 more
doaj   +1 more source

Transcription Factor SATB2 Regulates Skeletal Muscle Cell Proliferation and Migration via HDAC4 in Pigs

Genes
Skeletal muscle development remarkably affects meat production and growth rate, regulated by complex regulatory mechanisms in pigs. Specific AT sequence-binding protein 2 (SATB2) is a classic transcription factor and chromatin organizer, which holds a ...
Fanqinyu Li, Chao Yan, Yilong Yao, Yalan Yang, Yanwen Liu, Danyang Fan, Junxing Zhao, Zhonglin Tang   +7 more
semanticscholar   +1 more source

Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation [PDF]

, 2015
In rodent models of Parkinsons disease (PD), dopamine neuron loss is accompanied by increased expression of angiotensin II (AngII), its type 1 receptor (AT1), and NADPH oxidase (Nox) in the nigral dopamine neurons and microglia.
Aboud, O, Biedermann, J, Gentleman, SM, Griffin, WS, Mrak, RE, Palmer, QD, Zawada, WM   +6 more
core   +2 more sources

Mandibular Condylar Cartilage in Development and Diseases: A PTHrP‐Centric View

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT The mandibular condylar cartilage (MCC) is a dual‐function component of the temporomandibular joint (TMJ), acting as both articular cartilage for jaw movement and growth cartilage for vertical growth of the mandibular condyle. Parathyroid hormone‐related protein (PTHrP) plays a critical role in orchestrating chondrogenesis in the long bone ...
Chiaki Tsutsumi‐Arai, Amy Tran, Yuki Arai, Wanida Ono, Noriaki Ono   +4 more
wiley   +1 more source

Cyclic Equibiaxial Tensile Strain Alters Gene Expression of Chondrocytes via Histone Deacetylase 4 Shuttling. [PDF]

PLoS ONE, 2016
OBJECTIVES:This paper aims to investigate whether equibiaxial tensile strain alters chondrocyte gene expression via controlling subcellular localization of histone deacetylase 4 (HDAC4).
Chongwei Chen, Xiaochun Wei, Zhi Lv, Xiaojuan Sun, Shaowei Wang, Yang Zhang, Qiang Jiao, Xiaohu Wang, Yongping Li, Lei Wei   +9 more
doaj   +1 more source

Neuromuscular magnetic stimulation counteracts muscle decline in ALS patients: results of a randomized, double-blind, controlled study [PDF]

, 2019
The aim of the study was to verify whether neuromuscular magnetic stimulation (NMMS) improves muscle function in spinal-onset amyotrophic lateral sclerosis (ALS) patients.
Cambieri, Chiara, Ceccanti, Marco, Cerbelli, Bruna, Cifelli, Pierangelo, Cristina Gori, Maria, Dobrowolny, Gabriella, Frasca, Vittorio, Giordano, Carla, Inghilleri, Maurizio, Lepore, Elisa, Musaro', Antonio, Onesti, Emanuela, Palma, Eleonora, Pisano, Annalinda, Roseti, Cristina, Ruffolo, Gabriele   +15 more
core   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Hdac4 Modulates Cranial Neural Crest Mesenchymal Cells In Intramembranous Ossification

International Dental Journal
Aim or purpose: Congenital craniofacial developmental defects refer to congenital abnormalities in the bones or soft tissues of the head and face, accounting for one-third of all congenital defects.The specific pathogenic mechanisms involve transcription
Shuai Wang, Xudong Wang, Hao Sun
doaj   +1 more source

Conditional deletion of HDAC4 from collagen type 2α1-expressing cells increases angiogenesis in vivo

Molecular Medicine, 2020
Background HDAC4 is a key regulator of chondrocyte hypertrophy and skeletal development, but it is not clear whether the increase in vascular invasion at growth plates is related to HDAC4 expression.
Lilan Gao, Shengchun Li, Xiaochun Wei, Guoqing Du, Dennis Wei, Lei Wei   +5 more
doaj   +1 more source