Results 11 to 20 of about 21,262 (243)

HDAC4 regulates skeletal muscle regeneration via soluble factors [PDF]

Frontiers in Physiology, 2018
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini, Chiara Noviello, Nicoletta Marroncelli, Sergio Adamo, Viviana Moresi, Viviana Moresi   +5 more
core   +6 more sources

Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology

Journal of Medicinal Chemistry, 2022
Huntington’s disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from a CAG repeat expansion in the huntingtin (HTT) gene.
N. Macabuag, William Esmieu, P. Breccia, R. Jarvis, W. Blackaby, O. Lazari, L. Urbonas, Maria Eznarriaga, Rachel G. Williams, Annelieke Strijbosch, R. van de Bospoort, K. Matthews, C. Clissold, Tammy Ladduwahetty, Huw D. Vater, Patrick Heaphy, D. Stafford, Hong-jun Wang, J. Mangette, G. Mcallister, V. Beaumont, T. Vogt, H. Wilkinson, E. Doherty, C. Dominguez   +24 more
semanticscholar   +3 more sources

Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injury [PDF]

Molecular Medicine, 2018
Background Histone deacetylases (HDACs) play a critical role in modulating myocardial protection and cardiomyocyte survivals. However, Specific HDAC isoforms in mediating myocardial ischemia/reperfusion injury remain currently unknown.
Ling Zhang, Hao Wang, Yu Zhao, Jianguo Wang, Patrycja M. Dubielecka, Shougang Zhuang, Gangjian Qin, Y Eugene Chin, Race L. Kao, Ting C. Zhao   +9 more
doaj   +4 more sources

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Cell Death & Disease
Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely ...
Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi   +12 more
semanticscholar   +4 more sources

HDAC4 Inhibitors as Antivascular Senescence Therapeutics

Oxidative Medicine and Cellular Longevity, 2022
Aging is an inevitable consequence of life, and during this process, the epigenetic landscape changes and reactive oxygen species (ROS) accumulation increases. Inevitably, these changes are common in many age‐related diseases, including neurodegeneration, hypertension, and cardiovascular diseases. In the current research, histone deacetylation 4 (HDAC4)
Chuoji Huang, Zhongxiao Lin, Xiaoyan Liu, Qian Ding, Jianghong Cai, Zhongyi Zhang, Peter Rose, Yi Zhun Zhu   +7 more
openaire   +3 more sources

Machine Learning-Based Integrative Analysis Identifies SUMOylation-Related Genes Underlying the Immune Heterogeneity of Sepsis. [PDF]

IET Syst Biol
This study identified an eight‐gene signature associated with SUMOylation using machine learning and bioinformatics approaches, which effectively stratifies sepsis patients into two distinct subtypes: immune‐suppressive and hyper‐inflammatory. This discovery not only reveals the critical role of SUMOylation in sepsis heterogeneity but also provides new
Li Z, Yang J, Dong J, Ye Z, Li C, Hu Y, Ren H, Li S, Ji Z.   +8 more
europepmc   +2 more sources

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

BMC Musculoskeletal Disorders, 2022
Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA).
Xiaodong Gu, Fei Li, Yangyang Gao, Xianda Che, Pengcui Li   +4 more
doaj   +1 more source

Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway

Chinese Medical Journal, 2021
. Background:. Histone deacetylase 4 (HDAC4) regulates chondrocyte hypertrophy and bone formation. The aim of the present study was to explore the effects of HDAC4 on Interleukin 1 beta (IL-1β)-induced chondrocyte extracellular matrix degradation and ...
Qi Ning, Ye-Hua Gan, Rui-Rui Shi, Juan-Hong Meng, Xiu-Yuan Hao   +4 more
doaj   +1 more source

PP2A Regulates HDAC4 Nuclear Import [PDF]

Molecular Biology of the Cell, 2008
Different signal-regulated serine/threonine kinases phosphorylate class II histone deacetylases (HDACs) to promote nuclear export, cytosolic accumulation, and activation of gene transcription. However, little is known about mechanisms operating in the opposite direction, which, possibly through phosphatases, should promote class II HDACs nuclear entry ...
BRANCOLINI, Claudio, CERNOTTA, Nadia, DELLO RUSSO C., FOTI, Carmela, GALLINARI P, ORSATTI L., PALLAORO M., PARONI, Gabriela, STEINKUHLER C, TALAMO F.   +9 more
openaire   +3 more sources

Histone deacetylase HDAC4 promotes gastric cancer SGC-7901 cells progression via p21 repression. [PDF]

PLoS ONE, 2014
Gastric cancer (GC) is one of the leading causes of cancer death in the world. The role of histone deacetylase 4 (HDAC4) in specific cell and tissue types has been identified.
Zhen-Hua Kang, Chun-Yan Wang, Wen-Liang Zhang, Jian-Tao Zhang, Chun-Hua Yuan, Ping-Wei Zhao, Yu-Yang Lin, Sen Hong, Chen-Yao Li, Lei Wang   +9 more
doaj   +1 more source