Results 21 to 30 of about 21,262 (243)

Structure-Based Identification of Novel Histone Deacetylase 4 (HDAC4) Inhibitors

Pharmaceuticals, 2022
Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. However, engineering specificity is an important goal.
Rupesh Agarwal, Pawat Pattarawat, Michael R. Duff, Hwa-Chain Robert Wang, Jerome Baudry, Jeremy C. Smith   +5 more
doaj   +3 more sources

HDAC4 [PDF]

Cell, 2004
RUNX2 is a transcription factor with a well-characterized role in bone development. In this issue of Cell, Vega and colleagues (Vega et al., 2004) show that HDAC4 interacts with RUNX2 and impacts upon chondrocyte hypertrophy and bone formation.
openaire   +3 more sources

Pharmacological and Genetic Inhibition of HDAC4 Alleviates Renal Injury and Fibrosis in Mice

Frontiers in Pharmacology, 2022
Histone deacetylase 4 (HDAC4) has been shown to be involved in cell proliferation, differentiation, and migration and is associated with a variety of cancers. However, the role of HDAC4 in renal fibrogenesis and its mechanisms are unclear.
Fengchen Shen, Xiying Hou, Tingting Li, Jianjun Yu, Huizhen Chen, Na Liu, Andong Qiu, Shougang Zhuang, Shougang Zhuang   +8 more
doaj   +1 more source

m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop

Oncogene, 2023
Pancreatic cancer (PC) is the most hypoxic cancer type among solid tumors. The dynamic changes of RNA N6-methyl-adenosine (m6A) contribute to tumor cells adaption to hypoxic microenvironmental. However, the regulatory mechanisms of hypoxia response in PC
Xiaoyan Liu, Maoxiao Feng, X. Hao, Zihan Gao, Zhaoxin Wu, Yuli Wang, Lutao Du, Chuan Wang   +7 more
semanticscholar   +1 more source

Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling

Zeitschrift für Induktive Abstammungs- und Vererbungslehre, 2023
This study aimed to investigate the effects of Ginsenoside Rh4 (Rh4) on inflammation-related hepatocellular carcinoma (HCC) progression and the underlying mechanism.
Ruiyuan Jiang, Shujuan Luo, Meng Zhang, Wei Wang, Shaoyuan Zhuo, Yajing Wu, Qingmei Qiu, Yuan Yuan, Xiao Jiang   +8 more
semanticscholar   +1 more source

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]

, 2016
Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith, Baehr, Leslie M, Bodine, Sue C, De Sousa, Luis Gustavo, Marcotte, George, Marshall, Andrea G, West, Daniel WD   +6 more
core   +6 more sources

HDAC4 depletion ameliorates IL‐13‐triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF‐κB signaling

Immunity, Inflammation and Disease, 2022
Introduction Allergic rhinitis (AR) is frequently known as a chronic respiratory disease with a global high prevalence. The pivotal roles of histone deacetylase 4 (HDAC4) in multiple human diseases have been underlined by numerous studies.
Hangyu Xu, Lingjun Wang, Huaqun Chen, Hefei Cai   +3 more
doaj   +1 more source

HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications

Frontiers in Molecular Biosciences, 2023
Controlling access to genomic information and maintaining its stability are key aspects of cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA and the assembly of protein complexes that regulate mainly ...
Emma Cuttini, Camilla Goi, Ester Pellarin, Riccardo Vida, C. Brancolini   +4 more
semanticscholar   +1 more source

Interleukin 1β triggers synaptic and memory deficits in Herpes simplex virus type-1-infected mice by downregulating the expression of synaptic plasticity-related genes via the epigenetic MeCP2/HDAC4 complex

Cellular and Molecular Life Sciences, 2023
Extensive research provides evidence that neuroinflammation underlies numerous brain disorders. However, the molecular mechanisms by which inflammatory mediators determine synaptic and cognitive dysfunction occurring in neurodegenerative diseases (e.g ...
D. D. Li Puma, C. Colussi, Bruno Bandiera, Giulia Puliatti, M. Rinaudo, S. Cocco, F. Paciello, A. Re, Cristian Ripoli, G. De Chiara, Alessia Bertozzi, A. Palamara, R. Piacentini, C. Grassi   +13 more
semanticscholar   +1 more source

HDAC4: Mechanism of Regulation and Biological Functions [PDF]

Epigenomics, 2014
The acetylation and deacetylation of histones plays an important role in the regulation of gene transcriptions. Histone acetylation is mediated by histone acetyltransferase; the resulting modification in the structure of chromatin leads to nucleosomal relaxation and altered transcriptional activation.
Zhengke, Wang, Gangjian, Qin, Ting C, Zhao   +2 more
openaire   +2 more sources