Results 51 to 60 of about 21,262 (243)

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection. [PDF]

, 2017
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Alland, Aung, Azad, Bannister, Barchowsky, Bell, Bird, Brilha, Chen, Chernov, Choudhary, Culley, de Ruijter, Dobaczewski, Elkington, Feng, Goldberg, Green, Gregoire, Gregoretti, Horiuchi, Jaspers, Khan, Kim, Kleinsteuber, Kubler, Kumar, Lee, Loffek, Lu, Maciejewska-Rodrigues, Majeed, McErlean, McGarry Houghton, Michael, Mittelstadt, Mortaz, Moser, Nasu, Omanakuttan, Ong, Ong, Roger, Shahbazian, Shammari, Singh, Swamy, Tezera, Thuong, Wallis, Wang, Wang, Wolffe   +52 more
core   +2 more sources

Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
Biomechanics plays a critical role in the modulation of chondrocyte function. The mechanisms by which mechanical loading is transduced into intracellular signals that regulate chondrocyte gene expression remain largely unknown. Histone deacetylase 4 (HDAC4) is specifically expressed in chondrocytes.
Chongwei, Chen, Xiaochun, Wei, Shaowei, Wang, Qiang, Jiao, Yang, Zhang, Guoqing, Du, Xiaohu, Wang, Fangyuan, Wei, Jianzhong, Zhang, Lei, Wei   +9 more
openaire   +2 more sources

HDAC4 integrates PTH and sympathetic signaling in osteoblasts [PDF]

Journal of Cell Biology, 2014
Parathyroid hormone (PTH) and the sympathetic tone promote Rankl expression in osteoblasts and osteoclast differentiation by enhancing cyclic adenosine monophosphate production through an unidentified transcription factor for PTH and through ATF4 for the sympathetic tone.
Obri, Arnaud, Makinistoglu, Munevver Parla., Zhang, Hong, Karsenty, Gerard   +3 more
openaire   +3 more sources

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, EarlyView.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke

Neurobiology of Disease, 2016
Mounting evidence suggests that epigenetic modifications play critical roles in the survival/death of stressed neurons. Chief among these modifications is the deacetylation of histones within the chromatin by histone deacetylases (HDACs). HDAC4 is highly
Hui Yuan, Kyle Denton, Lin Liu, Xue-Jun Li, Sharon Benashski, Louise McCullough, Jun Li   +6 more
doaj   +1 more source

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity [PDF]

, 2016
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy.
Abraham, Reimar, Agatea, Lisa, Akimoto, Takayuki, Bicciato, Silvio, Blaauw, Bert, Calabria, Elisa, Carvajal, Jaime J., Ciciliot, Stefano, Dyar, Kenneth A., Forcato, Mattia, Moretti, Irene, Murgia, Marta, Pierre, Philippe, Rigby, Peter W. J., Schiaffino, Stefano, Uhlenhaut, N. Henriette   +15 more
core   +5 more sources

Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4. [PDF]

, 2017
Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through
Chawla, Ajay, Huang, Wendong, Paulo, Esther, Wang, Biao, Wang, Yangmeng, Wu, Dongmei, Wu, Yixuan   +6 more
core   +1 more source

HDAC4 is required for inflammation-associated thermal hypersensitivity [PDF]

The FASEB Journal, 2015
Transcriptional alterations are characteristic of persistent pain states, but the key regulators remain elusive. HDAC4 is a transcriptional corepressor that has been linked to synaptic plasticity and neuronal excitability, mechanisms that may be involved in peripheral and central sensitization.
Crow, Megan, Khovanov, Nikita, Kelleher, Jayne H, Sharma, Simone, Grant, Andrew D, Bogdanov, Yury, Wood, John N, McMahon, Stephen B, Denk, Franziska   +8 more
openaire   +5 more sources

HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70

Cell Reports, 2019
Summary: HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name “histone” deacetylase, HDAC4
Liqing Luo, Sherry C. Martin, Jascha Parkington, Samuel M. Cadena, Jiang Zhu, Chikwendu Ibebunjo, Serge Summermatter, Nicole Londraville, Krystyna Patora-Komisarska, Leo Widler, Huili Zhai, Anne-Ulrike Trendelenburg, David J. Glass, Jun Shi   +13 more
doaj   +1 more source

14-3-3 binding motif phosphorylation disrupts Hdac4 organized condensates to stimulate cardiac reprogramming

bioRxiv, 2023
Cell fate conversion is associated with extensive epigenetic and post translational modifications (PTMs) and architectural changes of sub-organelles and organelles, yet how these events are interconnected remains unknown.
Liu Liu, Ienglam Lei, Shuo Tian, Wenbin Gao, Yijing Guo, Zhaokai Li, Ziad Sabry, Paul Tang, Y. E. Chen, Zhong Wang   +9 more
semanticscholar   +1 more source