Results 61 to 70 of about 21,262 (243)

A shared mechanism of muscle wasting in cancer and Huntington's disease. [PDF]

, 2015
Skeletal muscle loss and dysfunction in aging and chronic diseases is one of the major causes of mortality in patients, and is relevant for a wide variety of diseases such as neurodegeneration and cancer.
Constantinou C, Inui A, Magnusson‐Lind A, Murphy KT, Zielonka D   +4 more
core   +2 more sources

Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis [PDF]

BioMed Research International, 2017
Acetylation or deacetylation of chromatin proteins and transcription factors is part of a complex signaling system that is involved in the control of neurological disorders. Recent studies have demonstrated that histone deacetylases (HDACs) exert protective effects in attenuating neuronal injury after ischemic insults.
Juan Liu, Xiang Zhou, Qing Li, Shu-Min Zhou, Bin Hu, Guo-Wen Hu, Xin Niu, Shang-Chun Guo, Yang Wang, Zhi-Feng Deng   +9 more
openaire   +2 more sources

LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low‐density lipoprotein‐induced injury of cardiac microvascular endothelial cells

Kaohsiung Journal of Medical Sciences, 2023
Long noncoding RNAs (LncRNAs) are essential to regulate the pathogenesis of coronary artery disease (CAD). This study was conducted to analyze the functionality of long noncoding RNA cancer susceptibility candidate 11 (lncRNA CASC11) in oxidized low ...
K. Hu, Minjiang Huang, Shan Ling, Yuxian Li, Xiang-yu Cao, Yuefu Chen, J. Lei, Wen-Zhe Fu, B. Tan   +8 more
semanticscholar   +1 more source

Third generation quinoline‐3‐carboxamide transcriptional disrupter of HDAC4, HIF‐1α, and MEF‐2 signaling for metastatic castration‐resistant prostate cancer

The Prostate, 2023
The quinoline‐3‐carboxamide, Tasquinimod (TasQ), is orally active as a maintenance therapy with an on‐target mechanism‐of‐action via allosteric binding to HDAC4.
John T. Isaacs, Susan L Dalrymple, L. Antony, David Marc Rosen, Ilsa M Coleman, Peter S. Nelson, M. Kostova, Iain A. Murray, G. Perdew, S. Denmeade, Emmanuel S. Akinboye, W. Brennen   +11 more
semanticscholar   +1 more source

Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy. [PDF]

, 2017
BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease ...
A Cevik, A Correa-Villasenor, A deAlmeida, A Granger, A Kulkarni, AP Vlahos, C Scholz, Carlin S Long, CL Antos, D Sedmera, DD Lemon, DJ Cao, Douglas D Lemon, J Lu, JP Cardinale, JW Newburger, JW Rossano, JW Rossano, Karin Nunley, Katharina M Lutter, KB Schuetze, Kimberly M Demos-Davies, KM Demos-Davies, M Tanno, MA Cavasin, MA Cavasin, Maria A Cavasin, MP Gupta, OA O'Connor, PA Marks, PC Frommelt, Q Yang, R Kirk, RG Ohye, S Chen, Sam Payne, SD Miyamoto, SD Miyamoto, SD Miyamoto, Shelley D Miyamoto, SJ Nakano, SK Mani, SM Williams, TA McKinsey, TG Gillette, Timothy A McKinsey, VM Klimek, Weston W Blakeslee, WJ Kowalski, WW Blakeslee   +49 more
core   +1 more source

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer [PDF]

, 2020
Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis.
Abu Nada, M, Ahmed, AA, Alajez, NM, Elkord, E, Kurer, MA, Murshed, K, Saleh, R, Sasidharan Nair, V, Taha, RZ, Toor, SM   +9 more
core   +3 more sources

HDAC4 in ischemic stroke: mechanisms and therapeutic potential [PDF]

Clinical Epigenetics, 2018
Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extremely narrow time window. Increased evidence suggests that histone deacetylase 4 (HDAC4) was dysregulated in ischemic stroke, which plays a key ...
Qingsheng Kong, Yongnan Hao, Xin Li, Xin Wang, Bingyuan Ji, Yili Wu   +5 more
openaire   +3 more sources

Promotion of microRNA-146a by histone deacetylase 4 silencing contributes to radiosensitization of esophageal carcinoma

Journal of Translational Medicine, 2022
Background Histone deacetylases (HDACs) have been identified to be implicated in the carcinogenesis and cancer progression. The present study was performed to probe into the effect of HDAC4 on radioresistance of esophageal carcinoma (EC).
Zhonghua Lu, Yifei Yun, Yutong Zhang, Yao Ou, Meihua Wang   +4 more
doaj   +1 more source

New insights into the epigenetic control of satellite cells [PDF]

, 2015
Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation.
Adamo, Sergio, Marroncelli, Nicoletta, Moresi, Viviana   +2 more
core   +1 more source

HDAC4 regulates vascular inflammation via activation of autophagy [PDF]

Cardiovascular Research, 2018
Angiotensin II (Ang II) causes vascular inflammation, leading to vascular endothelial cell dysfunction, and is associated with the development of cardiovascular diseases. Therefore, interventions in inflammation may contribute to the reduction of cardiovascular diseases.
Di, Yang, ChenXi, Xiao, Fen, Long, ZhengHua, Su, WanWan, Jia, Ming, Qin, MengWei, Huang, WeiJun, Wu, Rinkiko, Suguro, XinHua, Liu, YiZhun, Zhu   +10 more
openaire   +2 more sources