Results 121 to 130 of about 198,478 (151)

Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart

American Journal of Physiology-Heart and Circulatory Physiology, 2001
Heat-shock proteins (HSPs) are an important family of endogenous, protective proteins. Overexpression of HSPs is protective against cardiac injury. Previously, we observed that dexamethasone activated heat-shock factor-1 (HSF-1) and induced a 60% increase in HSP72 in adult cardiac myocytes.
A A, Knowlton, L, Sun
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Heat shock factor 1 prevents the reduction in thrashing due to heat shock in Caenorhabditis elegans

Biochemical and Biophysical Research Communications, 2015
Heat shock factor 1 (HSF-1) is activated by heat stress and induces the expression of heat shock proteins. However, the role of HSF-1 in thermotolerance remains unclear. We previously reported that heat stress reversibly reduces thrashing movement in Caenorhabditis elegans.
Tsubasa, Furuhashi, Kazuichi, Sakamoto
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Role of Heat Shock Factor 1 in HIV

2020
Introduction Viral infection is one of the triggers to heat shock response which is an evolutionarily conserved cell protection mechanism in eukaryotic cells and is closely related to the key transcriptional factor heat shock factor 1 (HSF1). It is generally recognized that HSF1 and its downstream factors especially heat shock proteins play extensive ...
Xinfeng Xu, Xiaoyan Pan, Shuwen Liu
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Expression and Purification of Human Heat-Shock Transcription Factor 1

Protein Expression and Purification, 1997
Heat-shock factor 1 (HSF1) is a 57-kDa cytoplasmic protein which binds to the promoters of heat-shock genes and activates transcription during heat shock. We describe here the expression and purification of the 529 amino acids form of human HSF1. We designed a new and complete purification protocol involving ammonium sulfate precipitation, heparin ...
Soncin, Fabrice, Prevelige, Robert, Calderwood, Stuart   +2 more
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Activation of heat shock factor 1 in rat brain during cerebral ischemia or after heat shock

Molecular Brain Research, 1995
Recently, many studies have demonstrated the induction of stress proteins in the mammalian nervous system under various pathological conditions. These altered genetic programs may function to protect individual cells against stressful conditions. However, little is known about the molecular mechanisms regulating these stress responses in animals.
T, Higashi, A, Nakai, Y, Uemura, H, Kikuchi, K, Nagata   +4 more
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Heavy metal response of the heat shock protein 70 gene is mediated by duplicated heat shock elements and heat shock factor 1

Gene, 2013
Heavy metals induce transcription of a number of mammalian genes, but in most cases the mechanism of induction has not been well characterized. The human heat shock protein 70 gene (hsp70) is activated by several heavy metals such as Cd and Zn, and the heat shock element (HSE) has been proposed to mediate metal response by previous studies. However, it
Shinji, Koizumi, Kaoru, Suzuki, Sachiko, Yamaguchi   +2 more
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Acute Pancreatitis Results in Induction of Heat Shock Proteins 70 and 27 and Heat Shock Factor-1

Pancreas, 2000
Heat shock proteins (HSPs) 70 and 27 are stress-responsive proteins that are important for cell survival after injury; the expression of these HSPs is regulated primarily by the transcription factor heat shock factor-1 (HSF-1). The purpose of this study was to determine the effect of acute pancreatitis on pancreatic HSPs (70, 27, 60, and 90) expression
R T, Ethridge, R A, Ehlers, M R, Hellmich, S, Rajaraman, B M, Evers   +4 more
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Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1

Biochemical and Biophysical Research Communications, 2003
The novel hydroxylamine derivative, bimoclomol, has been shown previously to act as a co-inducer of several heat shock proteins (Hsp-s), enhancing the amount of these proteins produced following a heat shock compared to heat shock alone. Here we show that the co-inducing effect of bimoclomol on Hsp expression is mediated via the prolonged activation of
Judit, Hargitai, Hannah, Lewis, Imre, Boros, Tímea, Rácz, András, Fiser, István, Kurucz, Ivor, Benjamin, László, Vígh, Zoltán, Pénzes, Péter, Csermely, David S, Latchman   +10 more
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Heat Shock Factor 1 as a Coordinator of Stress and Developmental Pathways

2007
The transition from normal growth conditions to stressful conditions is accompanied by a robust upregulation of heat shock proteins, which dampen the cytotoxicity caused by misfolded and denatured proteins. The most prominent part of this transition occurs on the transcriptional level. In mammals, protein-damaging stress leads to the activation of heat
Julius, Anckar, Lea, Sistonen
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bag3 gene expression is regulated by heat shock factor 1

Journal of Cellular Physiology, 2008
AbstractBAG3 protein, a member of the BAG co‐chaperones family, sustains cell survival, through its interaction with the heat shock protein (HSP) 70, in a variety of normal and neoplastic cell types. bag3 gene expression is induced by stressful stimuli.
FRANCESCHELLI, Silvia, ROSATI, ALESSANDRA, LEROSE R, DE NICOLA S, TURCO, Maria Caterina, PASCALE, Maria   +5 more
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