Results 141 to 150 of about 114,576 (360)
Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling
bioRxiv, 2019 In the absence of hedgehog ligand, patched-1 (Ptch1) localizes to cilia and prevents ciliary accumulation and activation of smoothened (Smo). Upon ligand binding, Ptch1 is removed from cilia, Smo is derepressed and accumulates in cilia where it activates
Paurav B. Desai +3 more
semanticscholar +1 more source
Sharpening our understanding of saber‐tooth biomechanics
The Anatomical Record, EarlyView.Abstract Saber‐teeth are a striking example of convergent evolution in vertebrate predators, having evolved multiple times in mammals and their early ancestors. While there is broad consensus that saber‐toothed taxa employed a distinct biting strategy compared to conical‐toothed carnivores, like the lion, the precise mechanics and variability of this ...
Tahlia Pollock, Philip S. L. Anderson
wiley +1 more source
Heart-beat of the Hibernating Hedgehog [PDF]
, 1951 Paavo Suomalainen, SAMULI SARAJAS
openalex +1 more source
Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer
Cells, 2019 The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie +3 more
semanticscholar +1 more source
China shares fossil treasures with the world
The Anatomical Record, EarlyView.Abstract China has been a rich source of fossils for nearly a century, beginning with the discovery of so‐called Peking man (Sinanthropus pekinensis), known today as Homo erectus pekinensis in the mid 1920s. The first Chinese dinosaurs were described in 1929, the sauropod Helopus (now Euhelopus) and the ornithopod Tanius, described by the Swedish ...
Peter Dodson
wiley +1 more source
X.—On some interesting hedgehogs from the Persian Gulf [PDF]
, 1922 Oldfield Thomas
openalex +1 more source
Animal Research and One Health, EarlyView.The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li +5 more
wiley +1 more source
Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection
BioEssays, EarlyView.Embryonic radial glia (RG) generate neurons, glial cells, and later adult neural stem cells, which sustain adult neurogenesis (top, left to right). Human‐specific genetic modifications (blue arrow), selected to boost early RG neurogenic activity, may lead to premature RG exhaustion and reduced adult neurogenesis in the human brain (bottom).
David Morizet, Laure Bally‐Cuif
wiley +1 more source
Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage
Biotechnology and Bioengineering, EarlyView.ABSTRACT Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material ...
Marc V. Farcasanu +8 more
wiley +1 more source