Results 141 to 150 of about 62,795 (214)

IQGAP3 activates Hedgehog signaling to confer stemness and metastasis via up-regulating GLI1 in lung cancer. [PDF]

Sci Rep
Li C, Liang L, Liang J, Tian C, Wang J, Liu Y, Hong X, Gu F, Zhang K, Hu Y, Liu L, Zeng Y.   +11 more
europepmc   +1 more source

Real‐World Data Analysis of Genomic Alterations Detected by a Dual DNA–RNA Comprehensive Genomic Profiling Test

Cancer Science, EarlyView.
This study analyzed 1356 cases using GenMineTOP, Japan's first dual DNA–RNA CGP test, and identified oncogenic alterations in 91.5% of cases. The RNA panel detected 105 fusion events, including 11 NTRK fusions. Furthermore, the analysis clarified the independent effects of genomic abnormalities and cancer type on RNA expression, providing valuable ...
Kousuke Watanabe, Miho Ogawa, Aya Shinozaki‐Ushiku, Shuichi Tsutsumi, Kenji Tatsuno, Hiroyuki Aburatani, Hidenori Kage, Katsutoshi Oda   +7 more
wiley   +1 more source

Computational investigation of naturally occurring anticancer agents in regulating Hedgehog pathway proteins. [PDF]

PLoS One
Pai R, Sirigiri DR, Malempati R, Vinjamuri S.   +3 more
europepmc   +1 more source

Diversity of U1 Small Nuclear RNAs and Diagnostic Methods for Their Mutations

Cancer Science, EarlyView.
Complex interindividual U1 snRNA diversity was unveiled. Mutations in such complex loci were precisely detected with a pangenome graph reference, which enhances the possibility of the human pangenome reference in cancer genomics. ABSTRACT U1 small nuclear RNA (snRNA) mutations are recurrent non‐coding alterations found in various malignancies, yet ...
Takuma Nakashima, Tsubasa Miyauchi, Ryota Takeuchi, Yuriko Sugihara, Yusuke Funakoshi, Fumiharu Ohka, Sachi Maeda, Junko Hirato, Takako Yoshioka, Hajime Okita, Yoshitaka Narita, Yonehiro Kanemura, Yasuhiro Kojima, Yuko Watanabe, Ryuta Saito, Hiromichi Suzuki   +15 more
wiley   +1 more source

Molecular Identification of <i>Borreliella</i> Species in <i>Ixodes hexagonus</i> Ticks Infesting Hedgehogs (<i>Erinaceus europaeus</i> and <i>E. roumanicus</i>) in North-Western Poland. [PDF]

Int J Mol Sci
Valentyna K, Beata W.
europepmc   +1 more source

Sonic hedgehog and fibroblast growth factor 8 regulate the evolution of amniote facial proportions. [PDF]

Commun Biol
Marchini M, Keller G, Khan N, Shah R, Saliceti Galarza A, Starr KB, Apostopoulos A, Sanger TJ.   +7 more
europepmc   +1 more source

Assessing the palatability of different meats consumed in a biodiversity hotspot to inform alternative protein interventions

Conservation Biology, EarlyView.
Abstract Alternative protein interventions are common in conservation. They aim to reduce the hunting or consumption of wildlife by promoting substitutes. However, selecting suitable meat substitutes is challenging because many factors drive wild meat consumption. Palatability, one such factor, drives consumer food preference and is potentially crucial
Charles A. Emogor, Isa B. Ebri, Benedict A. Atsu, Dominic S. Ogu, Omini B. Iferi, Andrew Balmford   +5 more
wiley   +1 more source

Genomic characterization and cross-species transmission potential of hedgehog coronavirus. [PDF]

One Health
Cruz AVS, Santos-Silva S, Queirós-Reis L, Rodrigues C, Soeiro V, Tarlinton RE, Mesquita JR.   +6 more
europepmc   +1 more source

Conditional Overexpression of Net1 Enhances the Trans‐Differentiation of Lgr5+ Progenitors into Hair Cells in the Neonatal Mouse Cochlea

Cell Proliferation, Volume 58, Issue 4, April 2025.
This work investigated the in vivo role of Net1 in cochlear hair cell (HC) regeneration. Conditional overexpression of Net1 in Lgr5+ progenitors of neonatal mouse cochlea enhance HC regeneration by inducing direct trans‐differentiation of Lgr5+ progenitors into HCs probably via activation of Atoh1, Gfi1, and Pou4f3 transcription factors.
Yanqin Lin, Qiuyue Zhang, Wei Tong, Yintao Wang, Leilei Wu, Hairong Xiao, Xujun Tang, Mingchen Dai, Zixuan Ye, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source