Results 11 to 20 of about 114,209 (360)
Hedgehog Signaling and Embryonic Craniofacial Disorders
Journal of Developmental Biology, 2019 Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog
John Abramyan
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Cold Spring Harbor Perspectives in Biology, 2012 Hedgehog (Hh) proteins constitute one family of a small number of secreted signaling proteins that together regulate multiple aspects of animal development, tissue homeostasis and regeneration. Originally uncovered through genetic analyses in Drosophila, their subsequent discovery in vertebrates has provided a paradigm for the role of morphogens in ...
Shuk Han Cheng, Siu Wah Choy
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Genome Biology, 2021 Aberrant activation of the Hedgehog pathway drives tumorigenesis of many cancers, including glioblastoma. However, the sensitization mechanism of the G protein-coupled-like receptor smoothened (SMO), a key component of Hedgehog signaling, remains largely
Xujia Wu +14 more
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Frontiers in Cell and Developmental Biology, 2021 Resistance to therapy is the major hurdle in the current cancer management. Cancer cells often rewire their cellular process to alternate mechanisms to resist the deleterious effect mounted by different therapeutic approaches.
Vivek Kumar +6 more
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Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria
Nature Communications, 2021 Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug ...
Yanping Long +10 more
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HEDGEHOGS IN LEHMER’S PROBLEM [PDF]
Bulletin of the Australian Mathematical Society, 2021 AbstractMotivated by a famous question of Lehmer about the Mahler measure, we study and solve its analytic analogue.
JAN-WILLEM M. VAN ITTERSUM +2 more
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Veterinary Clinics of North America: Exotic Animal Practice, 2020 African pygmy hedgehogs are popular pets worldwide. The knowledge and understanding of pet hedgehog common veterinary conditions are increasing as new information and research are published; however, there is still much to learn about this fascinating animal.
Keeble, Emma, Koterwas, Bronwyn
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Emerging Infectious Diseases, 2005 Exotic pets, including hedgehogs, have become popular in recent years among pet owners, especially in North America. Such animals can carry and introduce zoonotic agents, a fact well illustrated by the recent outbreak of monkeypox in pet prairie dogs.
Patricia Y. Riley, Bruno B. Chomel
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Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer
Clinical Cancer Research, 2021 Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by an extensive fibroinflammatory stroma, which includes abundant cancer-associated fibroblast (CAF) populations.
N. Steele +35 more
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