Results 21 to 30 of about 161,537 (288)
Frontiers in Pharmacology, 2021 Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system. Temozolomide (TMZ)–based adjuvant treatment has improved overall survival, but clinical outcomes remain poor; TMZ resistance is one of the main reasons for ...
Ming Ji +10 more
doaj +1 more source
Effective response theory for zero energy Majorana bound states in three spatial dimensions [PDF]
, 2015 We propose a gravitational response theory for point defects (hedgehogs) binding Majorana zero modes in (3+1)-dimensional superconductors. Starting in 4+1 dimensions, where the point defect is extended into a line, a coupling of the bulk defect texture ...
Lopes, Pedro L. S. +2 more
core +2 more sources
Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment
Frontiers in Cell and Developmental Biology, 2023 Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to cancer development via alteration of cell-autonomous oncogenic signaling ...
Wan-Hsin Lin +2 more
doaj +1 more source
Quantum stabilization of a hedgehog type of cosmic string [PDF]
, 2017 Within a slightly simplified version of the electroweak standard model we investigate the stabilization of cosmic strings by fermion quantum fluctuations.
Graham, N., Quandt, M., Weigel, H.
core +3 more sources
Emerging Infectious Diseases, 2005 Exotic pets, including hedgehogs, have become popular in recent years among pet owners, especially in North America. Such animals can carry and introduce zoonotic agents, a fact well illustrated by the recent outbreak of monkeypox in pet prairie dogs.
Patricia Y. Riley, Bruno B. Chomel
openaire +3 more sources
Frontiers in Physiology, 2018 Hedgehog signaling pathway participates in a chain of necessary physiological activities and dysregulation of the hedgehog signaling has been implicated in birth defects and diseases.
Huijuan Li +4 more
doaj +1 more source
Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life. [PDF]
, 2018 Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic ...
Roelink, Henk
core +3 more sources
Targeting hedgehog-driven mechanisms of drug-resistant cancers
Frontiers in Molecular Biosciences, 2023 Due to the cellular plasticity that is inherent to cancer, the acquisition of resistance to therapy remains one of the biggest obstacles to patient care.
Jade S. Miller +12 more
doaj +1 more source
eLife, 2016 Crucial roles for T-box3 in development are evident by severe limb malformations and other birth defects caused by T-box3 mutations in humans. Mechanisms whereby T-box3 regulates limb development are poorly understood.
Uchenna Emechebe +6 more
doaj +1 more source
Hedgehog Signaling Modulates Glial Proteostasis and Lifespan
Cell Reports, 2020 Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis +6 more
doaj +1 more source