Results 21 to 30 of about 114,209 (360)
Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments
International Journal of Molecular Sciences, 2020 During mammalian embryonic development, primary cilia transduce and regulate several signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most significant. SHH signaling remains quiescent in adult mammalian tissues. However,
K. Jeng, Chiung-Fang Chang, Shuru Lin
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Development, 2016 The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic ...
Lee, Raymond Teck Ho +2 more
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Molecules, 2019 Sonic hedgehog (Shh) signaling plays a tumor-promoting role in many epithelial cancers. Cancer cells produce soluble a Shh that signals to distant stromal cells that express the receptor Patched (Ptc).
Dominique Manikowski +3 more
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Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
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Hedgehog signaling in animal development: paradigms and principles.
Genes & Development, 2001 Since their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be recognized as key mediators of many fundamental processes in embryonic development.
P. Ingham, A. McMahon
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Frontiers in Physiology, 2018 Hedgehog signaling pathway participates in a chain of necessary physiological activities and dysregulation of the hedgehog signaling has been implicated in birth defects and diseases.
Huijuan Li +4 more
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Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling [PDF]
Nature Communications, 2021 AbstractHedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity ...
Samuel C. Griffiths +11 more
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bioRxiv, 2021 Previously, we showed that cholinergic interneurons of the dorsal striatum lose cilia in mice harboring the Parkinson’s disease associated, kinase activating, R1441C LRRK2 mutation (Dhekne et al., 2018).
Shahzad S Khan +6 more
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Hedgehog Signaling and Truncated GLI1 in Cancer
Cells, 2020 The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a consequence of improper control, aberrant HH signaling results in tumorigenesis and supports aggressive phenotypes of human cancers, such as neoplastic ...
Daniel L Doheny +3 more
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eLife, 2016 Crucial roles for T-box3 in development are evident by severe limb malformations and other birth defects caused by T-box3 mutations in humans. Mechanisms whereby T-box3 regulates limb development are poorly understood.
Uchenna Emechebe +6 more
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