Results 61 to 70 of about 161,537 (288)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Response of nucleons to external probes in hedgehog models: II. General formalism

, 1992
Linear response theory for SU(2) hedgehog soliton models is developed.Comment: 25 pages, DOE/ER/40322-163, U.
A. Kerman, B. Golli, B. Schwesinger, C.-Y. Ren, D. I. Dyakonov, D. I. Dyakonov, D. I. Dyakonov, D. J. Rowe, E. Witten, E. Witten, G. 't Hooft, G. Kalberman, G. R. S. Kahana, G. S. Adkins, G. S. Adkins, H. Reinhardt, I. Duck, I. J. R. Aitchison, I. J. R. Aitchison, I. J. R. Aitchison, I. Zahed, J. A. Zuk, J. Goldstone, L. Vepstas, M. C. Birse, M. C. Birse, M. C. Birse, M. C. Birse, M. Fiolhais, M. Gell-Mann, M. K. Banerjee, M. K. Banerjee, P. Ring, R. Alkofer, R. Friedberg, R. I. Nepomechi, R. Jackiw, R. Jackiw, S. A. Chin, S. Kahana, T. D. Cohen, T. D. Cohen, T. Eguchi, T. H. R. Skyrme, T. H. R. Skyrme, Th. Meissner, Th. Meissner, Thomas D. Cohen, V. I. Arnold, W. Broniowski, W. Broniowski, W. Broniowski, W. Broniowski, W. Broniowski, W. Broniowski, W. Broniowski, Wojciech Broniowski, Y. Nambu   +57 more
core   +1 more source

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]

, 2010
Background: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
Ingham, P.W., Kim, H.R., Richardson, J., van Eeden, F.   +3 more
core   +3 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Hedgehog Spin-vortex Crystal Antiferromagnetic Quantum Criticality in CaK(Fe1-xNix)4As4 Revealed by NMR [PDF]

, 2018
Two ordering states, antiferromagnetism and nematicity, have been observed in most iron-based superconductors (SCs). In contrast to those SCs, the newly discovered SC CaK(Fe$_{1-x}$Ni$_x$)$_4$As$_4$ exhibits an antiferromagnetic (AFM) state, called ...
Bud’ko, Sergey, Böhmer, A. E., Canfield, Paul, Canfield, Paul, Cui, J., Ding, Qingping, Furukawa, Yuji, Meier, William, Xu, Mingyu   +8 more
core   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling

eLife, 2021
Morphogen signaling proteins disperse across tissues to activate signal transduction in target cells. We investigated dispersion of Hedgehog (Hh), Wnt homolog Wingless (Wg), and Bone morphogenic protein homolog Decapentaplegic (Dpp) in the Drosophila ...
Ryo Hatori, Brent M Wood, Guilherme Oliveira Barbosa, Thomas B Kornberg   +3 more
doaj   +1 more source

Hedgehog Bases for A_n Cluster Polylogarithms and An Application to Six-Point Amplitudes

, 2015
Multi-loop scattering amplitudes in N=4 Yang-Mills theory possess cluster algebra structure. In order to develop a computational framework which exploits this connection, we show how to construct bases of Goncharov polylogarithm functions, at any weight,
Parker, Daniel E., Scherlis, Adam, Spradlin, Marcus, Volovich, Anastasia   +3 more
core   +1 more source

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [PDF]

, 2007
Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network.
Davidson, Eric H., Giles, Shane, Ji, Hongkai, Longabaugh, William J. R., McCuine, Scott, McMahon, Andrew P., Tenzen, Toyoaki, Vokes, Steven A., Wong, Wing H., Zhong, Sheng   +9 more
core   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source