Results 231 to 240 of about 2,340,031 (328)

Conditional Overexpression of Net1 Enhances the Trans‐Differentiation of Lgr5+ Progenitors into Hair Cells in the Neonatal Mouse Cochlea

Cell Proliferation, Volume 58, Issue 4, April 2025.
This work investigated the in vivo role of Net1 in cochlear hair cell (HC) regeneration. Conditional overexpression of Net1 in Lgr5+ progenitors of neonatal mouse cochlea enhance HC regeneration by inducing direct trans‐differentiation of Lgr5+ progenitors into HCs probably via activation of Atoh1, Gfi1, and Pou4f3 transcription factors.
Yanqin Lin, Qiuyue Zhang, Wei Tong, Yintao Wang, Leilei Wu, Hairong Xiao, Xujun Tang, Mingchen Dai, Zixuan Ye, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma

Clinical Cancer Research, 2018
R. Gordon, Li Zhang, S. Peri, Yin-Ming Kuo, Fang Du, B. Egleston, Jessica M. Y. Ng, A. Andrews, I. Astsaturov, T. Curran, Zeng-jie Yang   +10 more
semanticscholar   +1 more source

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

GLI PROTEINS, KEY MEDIATORS OF HEDGEHOG PATHWAY IN PANCREATIC CANCER CELLS, FUNCTION VIA THE INTERACTION WITH A P300 AND BRG CONTAINING COMPLEX

, 2006
C. Lokko, Jing Han, Martín E. Fernández-Zapico   +2 more
openalex   +1 more source

Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long‐Term Functional Evaluation

Cell Proliferation, EarlyView.
We optimised a protocol that combines developmental patterning with mechanical cut to produce pint‐sized midbrain organoids, with diameters less than 300 μm, suitable for long‐term evaluation, along with a comprehensive functional assay system consisting of calcium transient assay, neurite extension assay, and multielectrode array assay. ABSTRACT Human
Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang, Baoyang Hu   +7 more
wiley   +1 more source

Regulation of Ci-SCFSlimb Binding, Ci Proteolysis, and Hedgehog Pathway Activity by Ci Phosphorylation

, 2007
Margery Smelkinson, Qianhe Zhou, Daniel Kalderon   +2 more
openalex   +1 more source

Blocking the hedgehog pathway inhibits hepatoblastoma growth [PDF]

, 2008
Melanie Eichenmüller, Ivonne Gruner, Beate Hagl, Beate Häberle, Josef Müller‐Höcker, Dietrich von Schweinitz, Roland Kappler   +6 more
openalex   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models

Cell Proliferation, EarlyView.
This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang, Farhad Soheilmoghaddam, Peter Pivonka, Joan Li, Samuel Rudd, Trifanny Yeo, Ji Tu, Yibo Zhu, Justin J. Cooper‐White   +8 more
wiley   +1 more source

Cross talk between hedgehog and epithelial–mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers [PDF]

, 2008
Hiroyuki Ohta, Kenta Aoyagi, Masahide Fukaya, Inaho Danjoh, Akishige Ohta, Noriyuki Isohata, Norihisa Saeki, Hirokazu Taniguchi, H Sakamoto, Tadakazu Shimoda, T. Tani, Teruhiko Yoshida, Hiroki Sasaki   +12 more
openalex   +1 more source