Results 231 to 240 of about 4,715,625 (390)

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened [PDF]

, 2002
James Chen, Jussi Taipale, Michael K. Cooper, Philip A. Beachy   +3 more
openalex   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

Biological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source

Hedgehog signaling in vertebrate and invertebrate limb patterning

, 2000
Javier Capdevila, Randy L. Johnson
openalex   +2 more sources

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists [PDF]

, 2002
Maria Frank-Kamenetsky, Xiaoyan M. Zhang, Steve Bottega, Oivin Guicherit, Hynek Wichterle, Henryk Dudek, David Bumcrot, Frank Y. Wang, Simon Jones, Janine Shulok, Lee L. Rubin, Jeffery A. Porter   +11 more
openalex   +1 more source

Real‐World Data Analysis of Genomic Alterations Detected by a Dual DNA–RNA Comprehensive Genomic Profiling Test

Cancer Science, EarlyView.
This study analyzed 1356 cases using GenMineTOP, Japan's first dual DNA–RNA CGP test, and identified oncogenic alterations in 91.5% of cases. The RNA panel detected 105 fusion events, including 11 NTRK fusions. Furthermore, the analysis clarified the independent effects of genomic abnormalities and cancer type on RNA expression, providing valuable ...
Kousuke Watanabe, Miho Ogawa, Aya Shinozaki‐Ushiku, Shuichi Tsutsumi, Kenji Tatsuno, Hiroyuki Aburatani, Hidenori Kage, Katsutoshi Oda   +7 more
wiley   +1 more source

Stromal Hedgehog Signaling Is Associated with Favorable Outcomes in Pancreatic Cancer. [PDF]

Int J Mol Sci
Manoukian P, Damhofer H, Zhao L, van Laarhoven HWM, Bijlsma MF.   +4 more
europepmc   +1 more source

Diversity of U1 Small Nuclear RNAs and Diagnostic Methods for Their Mutations

Cancer Science, EarlyView.
Complex interindividual U1 snRNA diversity was unveiled. Mutations in such complex loci were precisely detected with a pangenome graph reference, which enhances the possibility of the human pangenome reference in cancer genomics. ABSTRACT U1 small nuclear RNA (snRNA) mutations are recurrent non‐coding alterations found in various malignancies, yet ...
Takuma Nakashima, Tsubasa Miyauchi, Ryota Takeuchi, Yuriko Sugihara, Yusuke Funakoshi, Fumiharu Ohka, Sachi Maeda, Junko Hirato, Takako Yoshioka, Hajime Okita, Yoshitaka Narita, Yonehiro Kanemura, Yasuhiro Kojima, Yuko Watanabe, Ryuta Saito, Hiromichi Suzuki   +15 more
wiley   +1 more source

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. [PDF]

, 2002
Barbara Stecca, Ariel Ruiz i Altaba
openalex   +1 more source