Results 241 to 250 of about 4,715,625 (390)

How Do Cancer Cells Create Cancer‐Associated Fibroblast Subtypes? Impacts of Extracellular Vesicles on Stromal Diversity

Cancer Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) are the major component of the tumor stroma. This review will highlight the CAF subtypes within the tumor microenvironment and their role in tumor progression. CAF subtype induction by extracellular vesicles (EVs) and their significance, which we reported previously, are also discussed.
Yutaka Naito
wiley   +1 more source

Hedgehog signaling controls astral microtubules and mitotic spindle orientation in neural progenitors and iPSCs. [PDF]

Front Cell Dev Biol
Liu F, Medyukhina A, Olesen KM, Shirinifard A, Jin H, Li L, Mapelli M, Khairy K, Han YG.   +8 more
europepmc   +1 more source

Roughing up Smoothened: chemical modulators of hedgehog signaling. [PDF]

, 2002
Randall W. King
openalex   +1 more source

PIK3C2A‐Related Clinical Phenotype and Cellular Charaterization Linked to Functional SHH Primary Cilia Defect

Clinical Genetics, EarlyView.
Trio exome sequencing allowed the identification of two novel compound heterozygous variants in PIK3C2A, defining the fifth family presenting a PIK3C2A‐related syndrome characterized by pulverulent cataracts and deafness. Functional testing revealed impaired PI metabolism and primary dysfunction phenotype.
Adella Karam, Clarisse Delvallée, Bénédicte Gérard, Elodie Javey, Pascal Kessler, Valérie Pelletier, Jean‐Baptiste Lamouche, Nicolas Le May, Jean Muller, Hélène Dollfus   +9 more
wiley   +1 more source

Hedgehog Signaling Functions in Spermatogenesis and Keeping Hemolymph-Testis Barrier Stability in <i>Eriocheir sinensis</i>. [PDF]

Int J Mol Sci
Yu JJ, Qi HY, Zhao Z, Yang Y, Zhang SY, Tan FQ, Yang WX.   +6 more
europepmc   +1 more source

Expression of a sonic hedgehog signal transducer, hedgehog-interacting protein, by human basal cell carcinoma [PDF]

, 2002
Michiko Tojo, Hidenori Kiyosawa, K Iwatsuki, Fumio Kaneko   +3 more
openalex   +1 more source

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

Cannabidiol exerts teratogenic effects on developing zebrafish through the sonic hedgehog signaling pathway. [PDF]

Sci Rep
Razmara P, Son HW, Ali DW.
europepmc   +1 more source

Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice [PDF]

, 2002
Li‐Chun Wang, Fatiha Nassir, Zhong–Ying Liu, Leona Ling, Frank C. Kuo, Thomas Crowell, Dian L. Olson, Nicholas O. Davidson, Linda C. Burkly   +8 more
openalex   +1 more source

Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long‐Term Functional Evaluation

Cell Proliferation, EarlyView.
We optimised a protocol that combines developmental patterning with mechanical cut to produce pint‐sized midbrain organoids, with diameters less than 300 μm, suitable for long‐term evaluation, along with a comprehensive functional assay system consisting of calcium transient assay, neurite extension assay, and multielectrode array assay. ABSTRACT Human
Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang, Baoyang Hu   +7 more
wiley   +1 more source