Minimal features of efficient incorporation of the hemagglutinin-neuraminidase protein into sendai virus particles. [PDF]
J Virol, 2014 ABSTRACT Two transmembrane glycoproteins form spikes on the surface of Sendai virus, a member of the Respirovirus genus of the Paramyxovirinae subfamily of the Paramyxoviridae family: the hemagglutinin-neuraminidase (HN) and the fusion (F) proteins.
Essaidi-Laziosi M, Shevtsova AS, Roux L.
europepmc +5 more sources
Viruses, 2021 Hemagglutinin and neuraminidase, which constitute the glycoprotein spikes expressed on the surface of influenza A and B viruses, are the most exposed parts of the virus and play critical roles in the viral lifecycle.
Yaqin Bai +3 more
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Frontiers in Chemistry, 2021 The inhibition of surface viral glycoproteins offers great potential to hamper the attachment of viruses to the host cells surface and the spreading of viral infection. Mumps virus (MuV) is the etiological agent of the mumps infectious disease and causes
Rosa Ester Forgione +10 more
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Influenza Neuraminidase Characteristics and Potential as a Vaccine Target
Frontiers in Immunology, 2021 Neuraminidase of influenza A and B viruses plays a critical role in the virus life cycle and is an important target of the host immune system. Here, we highlight the current understanding of influenza neuraminidase structure, function, antigenicity ...
Sarah Creytens +7 more
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Functional interactions between the fusion protein and hemagglutinin-neuraminidase of human parainfluenza viruses [PDF]
Journal of Virology, 1992 The fusion glycoprotein (F) and hemagglutinin-neuraminidase (HN) genes of human parainfluenza virus type 2 (PI2) were molecularly cloned and expressed in HeLa-T4 cells by using the vaccinia virus-T7 transient expression system. Expression of the F and HN proteins was detected by using immunoprecipitation and surface immunofluorescence staining ...
X L, Hu, R, Ray, R W, Compans
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The Hemagglutinin-Neuraminidase Protein of Newcastle Disease Virus Determines Tropism and Virulence [PDF]
Journal of Virology, 2004 ABSTRACT The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) plays a crucial role in the process of infection. However, the exact contribution of the HN gene to NDV pathogenesis is not known. In this study, the role of the HN gene in NDV virulence was examined. By use of reverse genetics procedures, the HN genes of a
Zhuhui, Huang +5 more
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Role of the Hemagglutinin-Neuraminidase Protein in the Mechanism of Paramyxovirus-Cell Membrane Fusion [PDF]
Journal of Virology, 2002 ABSTRACT Paramyxovirus infects cells by initially attaching to a sialic acid-containing cellular receptor and subsequently fusing with the plasma membrane of the cells. Hemagglutinin-neuraminidase (HN) protein, which is responsible for virus attachment, interacts with the fusion protein in a virus type-specific manner to induce ...
Toru, Takimoto +4 more
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‘a’-Position-Mutated and G4-Mutated Hemagglutinin-Neuraminidase Proteins of Newcastle Disease Virus Impair Fusion and Hemagglutinin-Neuraminidase-Fusion Interaction by Different Mechanisms [PDF]
Intervirology, 2012 <b><i>Objectives:</i></b> To determine the effects of heptad repeat regions (HRs) and N-linked carbohydrate sites of the Newcastle disease virus hemagglutinin-neuraminidase (HN) protein on fusion of HN and fusion (F) proteins and HN-F interaction.
Fu-lu, Chu +8 more
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Locally Acquired Human Infection with Swine-Origin Influenza A(H3N2) Variant Virus, Australia, 2018
Emerging Infectious Diseases, 2020 In 2018, a 15-year-old female adolescent in Australia was infected with swine influenza A(H3N2) variant virus. The virus contained hemagglutinin and neuraminidase genes derived from 1990s-like human seasonal viruses and internal protein genes from ...
Yi-Mo Deng +11 more
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Exploring the Mumps Virus Glycoproteins: A Review
Viruses, 2022 The resurgence of mumps in vaccinated adult populations has raised concerns about possible waning vaccine immunity or a potential lack of protection to the circulating strain.
Jasmine Rae Frost +2 more
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