Results 31 to 40 of about 16,332 (165)

Residues 315 and 369 in HN Protein Contribute to the Thermostability of Newcastle Disease Virus

Frontiers in Microbiology, 2020
Thermostable Newcastle disease virus (NDV) vaccines have been widely used in areas where a “cold-chain” is not reliable. However, the molecular mechanism of NDV thermostability remains poorly understood.
Baoyang Ruan, Xiaorong Zhang, Chengcheng Zhang, Pengyu Du, Chengcheng Meng, Mengjiao Guo, Yantao Wu, Yongzhong Cao   +7 more
doaj   +1 more source

Aberrant Cellular Glycosylation May Increase the Ability of Influenza Viruses to Escape Host Immune Responses through Modification of the Viral Glycome

mBio, 2022
Individuals with metabolic dysregulation of cellular glycosylation often experience severe influenza disease, with a poor immune response to the virus and low vaccine efficacy.
Irina V. Alymova, John F. Cipollo, Lisa M. Parsons, Nedzad Music, Ram P. Kamal, Wen-Pin Tzeng, Cynthia S. Goldsmith, Joseph N. Contessa, Kevan L. Hartshorn, Jason R. Wilson, Hui Zeng, Shane Gansebom, Ian A. York   +12 more
doaj   +1 more source

Broadly Protective Neuraminidase-Based Influenza Vaccines and Monoclonal Antibodies: Target Epitopes and Mechanisms of Action

Viruses, 2023
Neuraminidase (NA) is an important surface protein on influenza virions, playing an essential role in the viral life cycle and being a key target of the immune system.
Nada Abbadi, Jarrod J. Mousa
doaj   +1 more source

Involvement of the Cytoplasmic Domain of the Hemagglutinin-Neuraminidase Protein in Assembly of the Paramyxovirus Simian Virus 5 [PDF]

Journal of Virology, 1999
ABSTRACTEfficient assembly of enveloped viruses at the plasma membranes of virus-infected cells requires coordination between cytosolic viral components and viral integral membrane glycoproteins. As viral glycoprotein cytoplasmic domains may play a role in this coordination, we have investigated the importance of the hemagglutinin-neuraminidase (HN ...
A P, Schmitt, B, He, R A, Lamb
openaire   +2 more sources

Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions

Viruses, 2021
In current seasonal influenza vaccines, neutralizing antibody titers directed against the hemagglutinin surface protein are the primary correlate of protection. These vaccines are, therefore, quantitated in terms of their hemagglutinin content.
Nidhi Mittal, Nayanika Sengupta, Sameer Kumar Malladi, Poorvi Reddy, Madhuraj Bhat, Raju S. Rajmani, Koen Sedeyn, Xavier Saelens, Somnath Dutta, Raghavan Varadarajan   +9 more
doaj   +1 more source

Antiviral Resistance in Influenza: Clinical and Public Health Implications. [PDF]

Influenza Other Respir Viruses
ABSTRACT Timely antiviral treatment and prevention can diminish the morbidity and mortality caused by influenza seasonal, zoonotic, and pandemic infections. However, the emergence of antiviral resistance threatens the utility of available agents and sometimes contributes to poor clinical outcomes.
Ngiam JN, Koh MCY, Hayden FG.
europepmc   +2 more sources

An Inactivated Influenza Virus Vaccine Approach to Targeting the Conserved Hemagglutinin Stalk and M2e Domains

Vaccines, 2019
Universal influenza virus vaccine candidates that focus on the conserved hemagglutinin (HA) stalk domain and the extracellular domain of the matrix protein 2 (M2e) have been developed to increase the breadth of protection against multiple strains.
Weina Sun, Allen Zheng, Robert Miller, Florian Krammer, Peter Palese   +4 more
doaj   +1 more source

An IL-17-EGFR-TRAF4 axis contributes to the alleviation of lung inflammation in severe influenza

Communications Biology, 2023
Excessive inflammation is a postulated cause of severe disease and death in respiratory virus infections. In response to severe influenza virus infection, adoptively transferred naïve hemagglutinin-specific CD4+ T cells from CD4+ TCR-transgenic 6.5 mice ...
Avijit Dutta, Chen-Yiu Hung, Tse-Ching Chen, Sung-Han Hsiao, Chia-Shiang Chang, Yung-Chang Lin, Chun-Yen Lin, Ching-Tai Huang   +7 more
doaj   +1 more source

Functional Analysis of Individual Oligosaccharide Chains of Sendai Virus Hemagglutinin-neuraminidase Protein

Bioscience, Biotechnology, and Biochemistry, 2003
The roles of N-linked glycosylation in the intracellular transport and biological activities of the Sendai virus hemagglutinin-neuraminidase (HN) protein were studied. The protein contains four potential N-glycosylation sites: N77, N448, N499, and N511.
SEGAWA, Hiroaki, INAKAWA, Akira, YAMASHITA, Tetsuro, TAIRA, Hideharu   +3 more
openaire   +2 more sources

Influenza A (N1-N9) and Influenza B (B/Victoria and B/Yamagata) Neuraminidase Pseudotypes as Tools for Pandemic Preparedness and Improved Influenza Vaccine Design

Vaccines, 2022
To better understand how inhibition of the influenza neuraminidase (NA) protein contributes to protection against influenza, we produced lentiviral vectors pseudotyped with an avian H11 hemagglutinin (HA) and the NA of all influenza A (N1–N9) subtypes ...
Kelly A. S. da Costa, Joanne Marie M. Del Rosario, Matteo Ferrari, Sneha Vishwanath, Benedikt Asbach, Rebecca Kinsley, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton   +9 more
doaj   +1 more source