Results 21 to 30 of about 16,332 (165)

Expression of the Sendai Virus Fusion Protein and the Hemagglutinin-neuraminidase Protein Using a Baculovirus Vector [PDF]

Bioscience, Biotechnology, and Biochemistry, 1993
The fusion (F) and hemagglutinin-neuraminidase (HN) glycoproteins of Sendai virus were expressed using a baculovirus expression vector to examine the structures and functions of these proteins. Both proteins were detected in Spodoptera frugiperda (Sf) cells infected with the recombinant viruses on immunoprecipitation and indirect immunofluorescence ...
Sato, Toshitsugu, Taira, Hideharu, Matsuura, Yoshiharu, Iwasaki, Kentaro, Katsumata, Teizo   +4 more
openaire   +1 more source

Roles of the Fusion and Hemagglutinin-Neuraminidase Proteins in Replication, Tropism, and Pathogenicity of Avian Paramyxoviruses [PDF]

Journal of Virology, 2011
ABSTRACT Virulent and moderately virulent strains of Newcastle disease virus (NDV), representing avian paramyxovirus serotype 1 (APMV-1), cause respiratory and neurological disease in chickens and other species of birds. In contrast, APMV-2 is avirulent in chickens.
Shin-Hee, Kim, Madhuri, Subbiah, Arthur S, Samuel, Peter L, Collins, Siba K, Samal   +4 more
openaire   +2 more sources

The Cytoplasmic Tail of Influenza A Virus Hemagglutinin and Membrane Lipid Composition Change the Mode of M1 Protein Association with the Lipid Bilayer

Membranes, 2021
Influenza A virus envelope contains lipid molecules of the host cell and three integral viral proteins: major hemagglutinin, neuraminidase, and minor M2 protein.
Larisa V. Kordyukova, Petr V. Konarev, Nataliya V. Fedorova, Eleonora V. Shtykova, Alexander L. Ksenofontov, Nikita A. Loshkarev, Lubov A. Dadinova, Tatyana A. Timofeeva, Sergei S. Abramchuk, Andrei V. Moiseenko, Lyudmila A. Baratova, Dmitri I. Svergun, Oleg V. Batishchev   +12 more
doaj   +1 more source

Isolation of a biologically active soluble form of the hemagglutinin-neuraminidase protein of Sendai virus [PDF]

Journal of Virology, 1988
As a first step in establishing the three-dimensional structure of the Sendai virus hemagglutinin-neuraminidase (HN), we have isolated and characterized a potentially crystallizable form of the molecule. The sequence of HN, a surface glycoprotein, predicts a protein with an uncharged hydrophobic region near the amino terminus which is responsible for ...
S D, Thompson, W G, Laver, K G, Murti, A, Portner   +3 more
openaire   +2 more sources

Rescue of a H3N2 influenza virus containing a deficient neuraminidase protein by a hemagglutinin with a low receptor-binding affinity.

PLoS ONE, 2012
Influenza viruses possess at their surface two glycoproteins, the hemagglutinin and the neuraminidase, of which the antagonistic functions have to be well balanced for the virus to grow efficiently. Ferraris et al.
Mathilde Richard, Alexandra Erny, Bertrand Caré, Aurélien Traversier, Mendy Barthélémy, Alan Hay, Yi Pu Lin, Olivier Ferraris, Bruno Lina   +8 more
doaj   +1 more source

Regulation of Paramyxovirus Fusion Activation: the Hemagglutinin-Neuraminidase Protein Stabilizes the Fusion Protein in a Pretriggered State [PDF]

Journal of Virology, 2012
ABSTRACT The hemagglutinin (HA)-neuraminidase protein (HN) of paramyxoviruses carries out three discrete activities, each of which affects the ability of HN to promote viral fusion and entry: receptor binding, receptor cleaving (neuraminidase), and triggering of the fusion protein.
Porotto, Matteo, Salah, Zuhair W., Gui, Long, DeVito, Ilaria, Jurgens, Eric M., Lu, Hong, Yokoyama, Christine C., Palermo, Laura M., Lee, Kelly K., Moscona, Anne   +9 more
openaire   +3 more sources

The Expression of Hemagglutinin by a Recombinant Newcastle Disease Virus Causes Structural Changes and Alters Innate Immune Sensing

Vaccines, 2021
Recombinant Newcastle disease viruses (rNDV) have been used as bivalent vectors for vaccination against multiple economically important avian pathogens. NDV-vectored vaccines expressing the immunogenic H5 hemagglutinin (rNDV-H5) are considered attractive
Fiona Ingrao, Victoria Duchatel, Isabel Fernandez Rodil, Mieke Steensels, Eveline Verleysen, Jan Mast, Bénédicte Lambrecht   +6 more
doaj   +1 more source

Mucosal Immunity against Neuraminidase Prevents Influenza B Virus Transmission in Guinea Pigs

mBio, 2019
Despite efforts to control influenza virus infection and transmission, influenza viruses still cause significant morbidity and mortality in the global human population each year.
Meagan McMahon, Ericka Kirkpatrick, Daniel Stadlbauer, Shirin Strohmeier, Nicole M. Bouvier, Florian Krammer   +5 more
doaj   +1 more source

Localization of a new neutralizing epitope on the mumps virus hemagglutinin–neuraminidase protein

Virus Research, 2001
Four protein fragments which span the entire hemagglutinin-neuraminidase protein (HN) of mumps virus were expressed in HeLa cells and cell extracts were tested for their capability to induce neutralizing antibodies in mice. Fragment HN3 (aa 213-372) was able to induce the production of hemagglutination-inhibiting and neutralizing antibodies.
Cusi M. G., Fischer S., Sedlmeier R., Valassina M., Valensin P. E., Donati M., Neubert W. J.   +6 more
openaire   +6 more sources

The Flu Epidemic in Russia in the 2013 - 2014 Season: Etiology, Antigenic Properties of Hemagglutinin and Neuraminidase Activity

Эпидемиология и вакцинопрофилактика, 2015
The present study describes etiological structure of population of influenza viruses that circulated in Russian Federation in epidemic season 2013 - 2014. It was shown that from 495 isolates influenza A(H1N1)pdm09 viruses comprise 46.3%, influenza A(H3N2)
T. G. Lobova, D. M. Danilenko, N. I. Konovalova, E. M. Yeropkina, S. M. Shchekanova, P. A. Petrova, E. G. Kornilova, M. Yu. Yeropkin   +7 more
doaj   +1 more source