Results 91 to 100 of about 137,322 (324)

Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis

Lipids in Health and Disease, 2023
Background Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play an effect on nonalcoholic steatohepatitis (NASH).
Xiwei Yuan, Lu Li, Ying Zhang, Rong Ai, Dongdong Li, Yao Dou, Mengmeng Hou, Dandan Zhao, Suxian Zhao, Yuemin Nan   +9 more
doaj   +1 more source

Crystallization of recombinant human heme oxygenase‐1 [PDF]

Protein Science, 1998
AbstractHeme oxygenase catalyzes the NADPH, 02, and cytochrome P450 reductase dependent oxidation of heme to biliverdin and carbon monoxide. One of two primary isozymes, HO‐1, is anchored to the endoplasmic reticulum membrane via a stretch of hydrophobic residues at the C‐terminus.
D J, Schuller, A, Wilks, P, Ortiz de Montellano, T L, Poulos   +3 more
openaire   +2 more sources

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Advanced Science, EarlyView.
This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou, Chao Lu   +13 more
wiley   +1 more source

Human Mesenchymal Stem Cells Elevate CD4+CD25+CD127low/- Regulatory T Cells of Asthmatic Patients via Heme Oxygenase-1

Iranian Journal of Allergy, Asthma and Immunology, 2013
Up-regulation of CD4+CD25+CD127low/- regulatory T cells (Tregs) is a new target in the treatment of asthma. Human bone marrow mesenchymal stem cells can up-regulate CD4+CD25+CD127low/- regulatory T cells in vitro,  meanwhile, heme oxygenase-1 (HO-1 ...
Jian-guo Li, Yong-xun Zhuan-sun, Bing Wen, Hao Wu, Feng-ting Huang, Hridaya bibhu Ghimire, Pi-xin Ran   +6 more
doaj  

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling [PDF]

, 2018
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen.
A Arfe, A Bauer, A Kardosh, A Salminen, AJ Shaywitz, B Fisslthaler, BR Gunter, C Liu, C Mo, C Patrono, CC Thornton, CH He, D Carling, DH Solomon, DM Thomson, EH Kobayashi, EL Fosbol, FY Li, H Mylroie, HP Lin, HT Cheng, I Tegeder, IE Schauer, J Lindhardsen, J Steffel, JA Mitchell, JM Cacicedo, JS Wang, K Iwasaki, K Zimmermann, LC Wu, ME Widlansky, MP Seldon, MP Soares, MT Nurmohamed, N Bhala, NJ Goodson, NM Davies, NM Davies, P Kale, PA Watson, R Chenevard, R Gozzelino, RS Bresalier, S Jacob, S Trelle, SE Nissen, SK Paulson, SK Paulson, SL Colombo, SS Hamdulay, SS Hamdulay, SW Ryter, TD Penning, TM MacDonald, VL King, WB White, X Liu, XM Liu, Y Hattori, ZQ Zou   +60 more
core   +4 more sources

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

PLoS ONE, 2018
During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
J. Belcher, Chunsheng Chen, J. Nguyen, Fuad A. Abdulla, Ping Zhang, Hao Nguyen, Phong Nguyen, T. Killeen, S. Miescher, Nathan Brinkman, K. Nath, C. Steer, G. Vercellotti   +12 more
semanticscholar   +1 more source

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Research Progress in Understanding the Relationship Between Heme Oxygenase-1 and Intracerebral Hemorrhage

Frontiers in Neurology, 2018
Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage.
Qian-Qian Li, Lan-Jun Li, Xin-Yu Wang, Yu-Ying Sun, Jun Wu   +4 more
doaj   +1 more source