European Heart Journal, 2015 AIMS Heme oxygenase-1 (HO-1) confers protection to the vasculature and suppresses inflammatory properties of monocytes and macrophages. It is unclear how HO-1 determines the extent of vascular dysfunction in mice and humans.
P. Wenzel +26 more
semanticscholar +1 more source
Nucleotide-induced conformational motions and transmembrane gating dynamics in a bacterial ABC transporter [PDF]
arXiv, 2014 ATP-binding cassette (ABC) transporters are integral membrane proteins that mediate the exchange of diverse substrates across membranes powered by ATP hydrolysis. We report results of coarse-grained dynamical simulations performed for the bacterial heme transporter HmuUV.
arxiv
Mechanisms of cell protection by heme oxygenase-1.
Annual Review of Pharmacology and Toxicology, 2010 Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe(2+), carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death.
R. Gozzelino, V. Jeney, M. Soares
semanticscholar +1 more source
Relationship between NOX4 level and angiotensin II signaling in Gitelman's syndrome. Implications with hypertension [PDF]
, 2015 Recent evidence showed that endogenous nicotinamide adenine dinucleotide phosphate-oxidase 4 (NOX4) may exert a protective role on the cardiovascular system inducing vasodilation, reduction of blood pressure, and anti-proliferative actions.
Calò, Lorenzo A +5 more
core
Far Infrared Sensing Of The Oxidation State Of Heme Proteins [PDF]
arXiv, 2003 We propose a biosensor based on the change of terahertz (THz) dielectric response when a biotarget binds to a probe. The feasibility of this biosensor is examined by studying the change of THz transmission for thin films of heme proteins myoglobin (Mb) and cytochrome C (CytC) as a function oxygen binding.
arxiv
A geometric flow on noncompact affine Riemannian manifolds [PDF]
arXivIn this paper, we obtain the existence criteria for a geometic flow on noncompact affine Riemannian manifolds. Our results can be regarded as a real version of Lee-Tam [19]. As an application, we prove that a complete noncompact Hessian manifold with nonnegative Hessian sectional curvature and bounded geometry is diffeomorphic to $\mathbb{R}^n$ if its ...
arxiv
The Dirichlet problem for a class of curvature equations in Minkowski space [PDF]
arXivIn this paper, we study the Dirichlet problem for a class of prescribed curvature equations in Minkowski space. We prove the existence of smooth spacelike hypersurfaces with a class of prescribed curvature and general boundary data based on establishing the \emph{a priori} $C^2$ estimates.
arxiv
Can optimal diversification beat the naive 1/N strategy in a highly correlated market? Empirical evidence from cryptocurrencies [PDF]
arXivThis study systematically examines how several alternative approaches considered affect three aspects that determine portfolio performance (the gross return, the transaction costs and the portfolio risk). We find that it is difficult to exploit the possible predictability of asset returns. However, the predictability of asset return volatility produces
arxiv
The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma [PDF]
, 2008 We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortezomib in Hodgkin lymphoma (L428) and non-Hodgkin's ...
Andrew Evens +9 more
core +1 more source