Results 51 to 60 of about 95,946 (230)
Heme Oxygenase-1 in Tumors: Is It a False Friend? [PDF]
Antioxidants & Redox Signaling, 2007 Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to biologically active products: carbon monoxide (CO), biliverdin, and ferrous iron. It participates in maintaining cellular homeostasis and plays an important protective role in the tissues by reducing oxidative injury, attenuating the inflammatory response, inhibiting cell apoptosis, and ...
Józkowicz, Alicja +2 more
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The Protective Role of Heme Oxygenase-1 in Atherosclerotic Diseases
International Journal of Molecular Sciences, 2019 Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin.
Y. Kishimoto, K. Kondo, Y. Momiyama
semanticscholar +1 more source
Haematologica, 2013 Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity of therapeutic factor VIII in experimental hemophilia A.
Yohann Repessé +14 more
doaj +1 more source
The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease [PDF]
Journal of Integrative Neuroscience, 2020 We show that down-regulation of circular ribonucleic acid 0001588 with small interfering-circular ribonucleic acid 0001588 mimics promoted caspase-3 and caspase-9 activity levels, increased lactate dehydrogenase activity levels, and reduced cell growth ...
Rongyan Zhu, Xiuyan Qi, Cuiping Liu, Dongxin Wang, Li Li, Xiaofeng Liu, Yongge Hou, Xiaohui Su, Huiqian Lin
doaj +1 more source
PLoS ONE, 2018 During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
J. Belcher +12 more
semanticscholar +1 more source
Neural Regeneration Research[INLINE:1] Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury models. Heme oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox homeostasis.
Zhihua Wang +4 more
doaj +1 more source
Heme Oxygenase-1 in Tissue Pathology [PDF]
The American Journal of Pathology, 2000 Heme is a versatile molecule in nature and serves as the prosthetic moiety for numerous hemoproteins involved in oxygen delivery, electron transfer, and signal transduction. 1 However, when left unattended, the same heme can promote free radical formation and lipid peroxidation, resulting in cell damage and tissue injury.
Manjeri A. Venkatachalam +3 more
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Production of Transgenic Micro-Pig Expressing Human Heme Oxygenase 1
Journal of Animal Reproduction and Biotechnology, 2015 Xenotransplantation of pig islet regarded as a good alternative to allotransplantation. However, cellular death mediated by hypoxia-reoxygenation injury after transplantation disturb success of this technique.
Ok Jae Koo, Hyun Ju Oh, Byeong Chun Lee
doaj +1 more source
Heme Oxygenase-1 Deficiency [PDF]
Indian Pediatrics, 2021 Manisha Madkaikar +2 more
openaire +5 more sources
Cell Death and Disease, 2019 Phenotypic changes of myeloid cells are critical to the regulation of premature aging, development of cancer, and responses to infection. Heme metabolism has a fundamental role in the regulation of myeloid cell function and activity.
Andreas Hedblom +7 more
semanticscholar +1 more source