Results 51 to 60 of about 96,308 (192)

Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis

open access: yesLipids in Health and Disease, 2023
Background Heme oxygenase 1 (HO-1) has an influential but insufficiently investigated effect on ferroptosis, which is a novel form of programmed cell death and may play an effect on nonalcoholic steatohepatitis (NASH).
Xiwei Yuan   +9 more
doaj   +1 more source

Heme oxygenase 1 overexpression increases iron fluxes in Caco-2 cells

open access: yesBiological Research, 2006
Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe.
MARÍA JOSE MENDIBURO   +3 more
doaj  

Enzymological and structural characterization of Arabidopsis thaliana heme oxygenase‐1

open access: yesFEBS Open Bio, 2022
Arabidopsis thaliana heme oxygenase‐1 (AtHO‐1), a metabolic enzyme in the heme degradation pathway, serves as a prototype for study of the bilin‐related functions in plants.
Jia Wang   +6 more
doaj   +1 more source

Naringin Decreases TNF-α and HMGB1 Release from LPS-Stimulated Macrophages and Improves Survival in a CLP-Induced Sepsis Mice. [PDF]

open access: yesPLoS ONE, 2016
Naringin, a flavanone glycoside extracted from various plants, has a wide range of pharmacological effects. In the present study, we investigated naringin's mechanism of action and its inhibitory effect on lipopolysaccharide-induced tumor necrosis factor-
Minchan Gil   +3 more
doaj   +1 more source

Pharmacological and Clinical Significance of Heme Oxygenase-1

open access: yesAntioxidants, 2021
This Special Issue collates and updates the current knowledge of the pharmacology and clinical applications concerning the enzyme heme oxygenase (HO) [...]
David E. Stec, Nader G. Abraham
doaj   +1 more source

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

open access: yesViruses, 2018
Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced in response to a wide range of stress conditions. HO-1 exerts antiviral activity against a broad range of viruses, including the Hepatitis C virus, the human ...
Chaker El Kalamouni   +11 more
semanticscholar   +1 more source

Human Mesenchymal Stem Cells Elevate CD4+CD25+CD127low/- Regulatory T Cells of Asthmatic Patients via Heme Oxygenase-1

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2013
Up-regulation of CD4+CD25+CD127low/- regulatory T cells (Tregs) is a new target in the treatment of asthma. Human bone marrow mesenchymal stem cells can up-regulate CD4+CD25+CD127low/- regulatory T cells in vitro,  meanwhile, heme oxygenase-1 (HO-1 ...
Jian-guo Li   +6 more
doaj  

Pharmacological Targeting of Heme Oxygenase-1 in Osteoarthritis

open access: yesAntioxidants, 2021
Osteoarthritis (OA) is a common aging-associated disease that clinically manifests as joint pain, mobility limitations, and compromised quality of life.
Yohei Sanada   +3 more
doaj   +1 more source

Heme Oxygenase 1 as a Therapeutic Target in Acute Kidney Injury.

open access: yesAmerican Journal of Kidney Diseases, 2017
A common clinical condition, acute kidney injury (AKI) significantly influences morbidity and mortality, particularly in critically ill patients. The pathophysiology of AKI is complex and involves multiple pathways, including inflammation, autophagy ...
Subhashini Bolisetty   +2 more
semanticscholar   +1 more source

Heme oxygenase-1, oxidation, inflammation and atherosclerosis

open access: yesFrontiers in Pharmacology, 2012
Atherosclerosis is an inflammatory process of the vascular wall characterized by the infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low density lipoproteins and induction of oxidative stress play a major role in ...
Jesus A Araujo, Min eZhang, Fen eYin
doaj   +1 more source

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