Results 131 to 140 of about 11,782 (206)

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, Volume 183, Issue 13, Page 3762-3779, July 2026.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source

Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions

Nature Communications
Vesicular transport is essential for delivering cargo to intracellular destinations. Evi5 is a Rab11-GTPase-activating protein involved in endosome recycling.
Sattar Soltani, Samuel M. Webb, Thomas Kroll, Kirst King-Jones   +3 more
doaj   +1 more source

Selective Autophagy Receptor CsNBR1 Confers Citrus Huanglongbing Resistance by Degrading ‘Candidatus Liberibacter Asiaticus’ Virulence Effectors

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
Overexpression of CsNBR1 confers HLB resistance in citrus by degrading CLas effector proteins, including SDE5115, SDE1, SDE19 and SDE5, via the autophagy pathway. ABSTRACT The selective autophagy receptor NEIGHBOUR OF BRCA1 (NBR1) is a key regulator of plant immunity, but its role against bacterial pathogens remains poorly understood.
Yaqian Shi, Xuejin Cui, Fang Fang, Zaiyu Yang, Yalin Mei, Shimian Ma, Changyong Zhou, Xuefeng Wang   +7 more
wiley   +1 more source

Heme Oxygenase‐1 Differentially Controls Pigmentation in Physiological and Pathological Melanogenesis

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
HO‐1 acts as a context‐dependent regulator of pigmentation, enhancing tyrosinase activity and melanin accumulation in melanoma cells while having no detectable effect on pigmentation in the non‐malignant melanocyte models tested. ABSTRACT Melanogenesis is a defining feature of melanocyte biology and influences melanoma pathogenesis; however, tumor ...
Agnieszka Seretny, Grażyna Jamróg, Jacek Stępniewski, Maciej Cieśla, Witold Nowak, Rościsław Krutyhołowa, Martin Petrovic, Anna Tejchman‐Skrzyszewska, Milena Mazan, Halina Waś, Wolfgang Weninger, Matthias Farlik, Alicja Józkowicz, Anna Kusienicka   +13 more
wiley   +1 more source

Localization of Heme Biosynthesis Pathway Enzymes in Plasmodium falciparum [PDF]

, 2008
365-373Protein trafficking in the malarial parasite Plasmodium falciparum is dictated by a complex life-cycle that involves a variety of intra-cellular and host cell destinations, such as the mitochondrion, apicoplast, rhoptries and micronemes. Of these,
Rao, Aditya, Bulusu, Gopalakrishnan, Srinivasan, Rajgopal, Yeleswarapu, Sri Jyothsna   +3 more
core  

Pathways of copper import and utilization that support respiration in Bacillus subtilis

mBio
Copper is an enzyme cofactor that is essential for cellular respiration in most aerobic organisms but can be toxic in excess. Although most copper enzymes are localized within or external to the cell membrane, proper copper loading often relies on copper
Grayson Barnes, Lars Hederstedt, Oriana S. Fisher, Claes von Wachenfeldt, John D. Helmann   +4 more
doaj   +1 more source

DELINEATING THE ROLES OF C. ELEGANS HEME RESPONSIVE GENES HRG-2 AND HRG-3 IN HEME HOMEOSTASIS [PDF]

, 2009
Heme is an essential cofactor for diverse biological processes such as oxygen transport, xenobiotic detoxification, and circadian clock control.
Chen, Caiyong
core  

PPE64 is a mycomembrane channel protein that functions in heme iron uptake and moonlights in biofilm formation in Mycobacterium tuberculosis

mBio
Mycobacterium tuberculosis (Mtb) is the leading cause of human deaths by an infectious agent. To survive in the human host, Mtb must acquire essential iron nutrients from the host and evade the immune response. In diderm bacteria like Mtb, outer membrane
Padam Singh, Charles B. Kaufman, Lisa Whitworth, Reed M. Stubbendieck, Randy Morgenstein, Karen L. Wozniak, Avishek Mitra   +6 more
doaj   +1 more source

The Alternative Haem Biosynthesis Pathway: Structure, Function and Properties of Sirohaem Decarboxylase [PDF]

, 2014
Haem, a cyclic tetrapyrrole, is found in organisms from all three domains of life. Haem is a prosthetic group for many proteins involved in essential biological processes such as respiration and oxygen transport.
Palmer, David James
core  

Mitochondrial-nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites.

J Cell Sci, 2020
Martinez-Guzman O, Willoughby MM, Saini A, Dietz JV, Bohovych I, Medlock AE, Khalimonchuk O, Reddi AR.   +7 more
europepmc   +1 more source