Results 121 to 130 of about 11,485 (176)

PPE64 is a mycomembrane channel protein that functions in heme iron uptake and moonlights in biofilm formation in Mycobacterium tuberculosis

mBio
Mycobacterium tuberculosis (Mtb) is the leading cause of human deaths by an infectious agent. To survive in the human host, Mtb must acquire essential iron nutrients from the host and evade the immune response. In diderm bacteria like Mtb, outer membrane
Padam Singh, Charles B. Kaufman, Lisa Whitworth, Reed M. Stubbendieck, Randy Morgenstein, Karen L. Wozniak, Avishek Mitra   +6 more
doaj   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, Volume 81, Issue 8, Page 2675-2712, August 2026.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Mitochondrial-nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites.

J Cell Sci, 2020
Martinez-Guzman O, Willoughby MM, Saini A, Dietz JV, Bohovych I, Medlock AE, Khalimonchuk O, Reddi AR.   +7 more
europepmc   +1 more source

Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in <i>Caenorhabditis elegans,</i> challenges a proposed role in heme trafficking. [PDF]

Elife
Sandkuhler SE, Youngs KS, Gottipalli O, Owlett LD, Bandora MB, Naaz A, Kim E, Wang L, Wojtovich A, Gupta V, Sacher M, Mackenzie SJ.   +11 more
europepmc   +1 more source

Live-cell tracking of biliverdin trafficking reveals metabolic exchange between plastids and peroxisomes. [PDF]

Biol Open
Shibata M, Yoshida K, Takahashi H, Kodama Y.   +3 more
europepmc   +1 more source

Iron as an immunometabolic signal in infection and inflammation. [PDF]

Front Immunol
Hoffmann A, Homs Pérez L, Weiss G.
europepmc   +1 more source

The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase. [PDF]

Acta Crystallogr D Struct Biol
Zhou D, Chen L, Rose J, Wang BC.
europepmc   +1 more source

Is heme metabolism a promising drug target in Toxoplasma gondii? [PDF]

PLoS Pathog
Dou Z.
europepmc   +1 more source

Fifty shades of iron: Unorthodox mechanisms of iron acquisition and utilization in blood-stage Plasmodium parasites. [PDF]

PLoS Pathog
Loveridge KM, Sigala PA.
europepmc   +1 more source