Results 211 to 220 of about 9,855 (254)
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Experimental Eye Research, 2020
Diabetic retinopathy (DR), the most common ocular complication associated with diabetes, is a chronic vascular and inflammatory disease that leads to vision loss.
H. Louie +5 more
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Diabetic retinopathy (DR), the most common ocular complication associated with diabetes, is a chronic vascular and inflammatory disease that leads to vision loss.
H. Louie +5 more
semanticscholar +1 more source
Hemichannels in Cerebral Ischemia
Current Molecular Medicine, 2009Hemichannels are transmembrane channels that represent the functional subunits of gap junctions. Each hemichannel is composed of a connexin or pannexin hexamer and, after being transported to the membrane, remains unpaired until it is incorporated in a gap junction. Several studies have already provided evidence that gap junction-mediated intercellular
Panagiotis, Bargiotas +2 more
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4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2020Hemichannels formed by connexins mediate the exchange of ions and signaling molecules between the cytoplasm and the extracellular milieu. Under physiological conditions hemichannels have a low open probability, but in certain pathologies their open ...
M. Retamal +7 more
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RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes.
Cardiovascular Research, 2019AIMS Connexin-based gap junctions are crucial for electrical communication in the heart; they are each composed of two docked hemichannels, supplied as unpaired channels via the sarcolemma.
Alessio Lissoni +9 more
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Biophysical characterization of zebrafish connexin35 hemichannels
American Journal of Physiology-Cell Physiology, 2004A subset of connexins can form unopposed hemichannels in expression systems, providing an opportunity for comparison of hemichannel gating properties with those of intact gap junction channels. Zebrafish connexin35 (Cx35) is a member of the Cx35/Cx36 subgroup of connexins highly expressed in the retina and brain.
Virginijus, Valiunas +5 more
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Functional connexin “hemichannels”: A critical appraisal
Glia, 2006Abstract“Hemichannels” are defined as the halves of gap junction channels (also termed connexons) that are contributed by one cell; “hemichannels” are considered to be functional if they are open in nonjunctional membranes in the absence of pairing with partners from adjacent cells.
David C, Spray +2 more
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Hemichannels: New pathways for gliotransmitter release
Neuroscience, 2015Growing evidence suggests that glial cells express virtually all known types of neurotransmitter receptors, enabling them to sense neuronal activity and microenvironment changes by responding locally via the Ca(2+)-dependent release of bioactive molecules, known as "gliotransmitters".
Montero, T.D. +1 more
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Ischemia Opens Neuronal Gap Junction Hemichannels
Science, 2006Neuronal excitotoxicity during stroke is caused by activation of unidentified large-conductance channels, leading to swelling and calcium dysregulation. We show that ischemic-like conditions [O 2 /glucose deprivation (OGD)] open hemichannels, or half gap junctions, in neurons.
Roger J, Thompson +2 more
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Gap junctional hemichannels in the heart
Acta Physiologica Scandinavica, 2003AbstractUpon contacting each other, cells form gap junctions, in which each cell contributes half of the channel linking their cytoplasms, enabling them to share their metabolome up to a molecular weight of 1000. Each hemichannel (or connexon) is randomly inserted into the plasma membrane and then migrates to the site of cell‐to‐cell contact before ...
S, John, D, Cesario, J N, Weiss
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Neurochemistry International, 2019
Dysregulation of blood-brain barrier (BBB) transport exacerbates brain damage in acute ischemic stroke. Here, we aimed to investigate the mechanism of this BBB transport dysregulation by studying the localization and function of pannexin (Px) and ...
M. Tachikawa +5 more
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Dysregulation of blood-brain barrier (BBB) transport exacerbates brain damage in acute ischemic stroke. Here, we aimed to investigate the mechanism of this BBB transport dysregulation by studying the localization and function of pannexin (Px) and ...
M. Tachikawa +5 more
semanticscholar +1 more source