Results 221 to 230 of about 9,855 (254)

Severe neuropathy with leaky connexin32 hemichannels

Annals of Neurology, 2005
AbstractX‐linked Charcot‐Marie‐Tooth disease is one of a set of diseases caused by mutations in gap junction proteins called connexins. We identified a connexin32 missense mutation (F235C) in a girl with unusually severe neuropathy. The localization and trafficking of the mutant protein in cell culture was normal, but electrophysiological studies ...
Grace S Lin, Liang, Marta, de Miguel, Juan M, Gómez-Hernández, Jonathan D, Glass, Steven S, Scherer, Mark, Mintz, Luis C, Barrio, Kenneth H, Fischbeck   +7 more
openaire   +2 more sources

Hemichannel-Mediated Inhibition in the Outer Retina

Science, 2001
An essential feature of the first synapse in the retina is a negative feedback pathway from horizontal cells to cones. Here we show that at this synapse, connexin26 forms hemichannels on horizontal cell dendrites near the glutamate release site of the cones. Blocking these hemichannels hyperpolarizes horizontal cells, modulates the Ca
Kamermans, M., Fahrenfort, I., Schultz, K., Janssen-Bienhold, U., Sjoerdsma, T., Weiler, R.   +5 more
openaire   +2 more sources

Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation.

Nitric oxide, 2019
Under normal conditions, connexin (Cx) hemichannels have a low open probability, which can increase under pathological conditions. Since hemichannels are permeable to relatively large molecules, their exacerbated activity has been linked to cell damage ...
M. Retamal, Viviana P Orellana, Nicolás J Arévalo, Cristóbal Rojas, R. J. Arjona, Constanza Alcaino, W. González, Jonathan Canan, R. Moraga-Amaro, J. Stehberg, L. Reuss, G. Altenberg   +11 more
semanticscholar   +1 more source

Connexin Hemichannel Inhibition and Human Genodermatoses

Journal of Investigative Dermatology
Pathogenic variants in genes encoding connexins that cause skin diseases, such as keratitis-ichthyosis-deafness (KID) syndrome and hidrotic ectodermal dysplasia (HED) or Clouston syndrome, display increased hemichannel activity. Mechanistic insights derived from biophysical studies of the variant connexins support the hypothesis that inhibition of the ...
Fabio Mammano, Amy S. Paller, Thomas W. White   +2 more
openaire   +2 more sources

Functional differences between human Cx37 polymorphic hemichannels

Journal of Molecular and Cellular Cardiology, 2009
A polymorphism in the human Cx37 gene (C1019T), resulting in a non-conservative amino acid change in the regulatory C-terminus of the Cx37 protein (P319S), has been proposed as a prognostic marker for atherosclerosis. We have recently demonstrated that Cx37 hemichannels control the initiation of atherosclerotic plaque development by regulating ATP ...
Derouette, Jean-Paul, Desplantez, Thomas, Wong, Cindy W., Roth, Isabelle, Kwak, Brenda, Weingart, Robert   +5 more
openaire   +3 more sources

Glial Cx43 hemichannels and neuronal Panx1 hemichannels and P2X7 receptors orchestrate presynaptic homeostatic plasticity

Cellular Signalling
The emerging role of glial cells in modulating neuronal excitability and synaptic strength is a growing field in neuroscience. In recent years, a pivotal role of gliotransmission in homeostatic presynaptic plasticity has been highlighted and glial-derived ATP arises as a key contributor.
Alberto, Rafael, Marina, Tizzoni, Cristian, Justet, Andrea, Cairus, Verónica, Abudara, Nathalia, Vitureira   +5 more
openaire   +2 more sources

Physiological Functions of Glial Cell Hemichannels

2016
The brain performs exceptionally complex and dynamic tasks that depend on the coordinated interaction of neurons, glial cells, endothelial cells, pericytes, smooth muscle cells, ependymal cells, and circulating blood cells. Among these cells, glial cells have emerged as crucial protagonists in the regulation of synaptic transmission and neural function.
openaire   +3 more sources

The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release.

Biochimica et Biophysica Acta - General Subjects, 2018
O. Mugisho, C. Green, Dan T. Kho, Jie Zhang, E. S. Graham, Monica L. Acosta, I. Rupenthal   +6 more
semanticscholar   +1 more source

Connexin43 hemichannel block protects against retinal pigment epithelial cell barrier breakdown

Acta Diabetologica, 2019
C. Kuo, C. Green, I. Rupenthal, O. Mugisho   +3 more
semanticscholar   +1 more source

Connexin Hemichannels

2020
openaire   +2 more sources