Results 141 to 150 of about 15,174 (240)

Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy

Frontiers in Cellular Neuroscience, 2018
Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca2+ transients, which are sensitive to purinergic receptor ...
Mario Wellmann, Mario Wellmann, Carla Álvarez-Ferradas, Carla Álvarez-Ferradas, Carola J. Maturana, Carola J. Maturana, Juan C. Sáez, Juan C. Sáez, Christian Bonansco   +8 more
doaj   +1 more source

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders [PDF]

, 2017
Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases.
Andrea Carrer, Anna M. Salvatore, Anselmi, Barbas, Barbas, Beck, Bedner, Beltramello, Bennett, Berendsen, Best, Bosen, Bosen, Boukamp, Breitling, Brenke, Bruzzone, Bujak, Burton, Ceriani, Chen, Chiara Nardin, Chiara Peres, Clackson, Clair, Comeau, Damiano Buratto, Darden, De Luca, DeVries, Djalilian, Dupont, Emsley, Esseltine, Essenfelder, Fabio Mammano, Fasciani, Federico Ceriani, Ferdinando Scavizzi, Flavia Mazzarda, Forge, Francesca Bruno, Francesco Zonta, Frenzel, Gaia Ziraldo, Garcia, Garcia, Gerido, Giulia Crispino, Goodenough, Guang Yang, Gumbart, Hernandez, Holliger, Housley, Jackson, Johnson, Jun Liao, Kanaporis, Kopecki, Larkin, Lee, Lee, Lefranc, Leibovici, Lerner, Levit, Liang Xu, Lipes, Maeda, Majumder, Marcello Raspa, Martin, Mavilio, McCafferty, McCoy, Mese, Mhaske, Minor, Murshudov, Niessen, Ortolano, Peixiang Ma, Perisic, Pronk, Remington, Retamal, Richard A. Lerner, Riquelme, Rodriguez, Rodriguez-Boulan, Saez, Saez, Sanchez, Sanchez, Schutz, Schutz, Shanshan Wang, Sheng Li, Sichun Xie, Srinivas, Stauffer, Stong, Tamai, Thomas, Tolar, Tritsch, Uitto, Veronica Zorzi, Wang, Wangemann, Weber, Wei Wang, Wilcox, Wingard, Wong, Wu, Xiao Liu, Xuemei Yang, Youjun Chu, Zhang, Zhao, Zhao, Zhihu Qu, Zong, Zonta   +125 more
core   +3 more sources

The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring

Frontiers in Cellular Neuroscience, 2019
Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
C. Chávez, J. E. Oyarzún, B. C. Avendaño, Luis A. Mellado, Carla A Inostroza, Tanhia F. Alvear, J. Orellana   +6 more
semanticscholar   +1 more source

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease

Frontiers in Cellular Neuroscience, 2019
Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper ...
Sebastián Vejar, Juan E. Oyarzún, Juan E. Oyarzún, Mauricio A. Retamal, Mauricio A. Retamal, Fernando C. Ortiz, Juan A. Orellana, Juan A. Orellana   +7 more
doaj   +1 more source

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

Frontiers in Cellular Neuroscience, 2015
Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Juan Andrés Orellana, Rodrigo eMoraga-Amaro, Raúl eDíaz-Galarce, sebastian eRojas, Carola J Maturana, Jimmy eStehberg, Juan C Saez   +6 more
doaj   +1 more source

Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone

Journal of Neuroinflammation, 2018
BackgroundGlia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage ...
Xiang Yin, Liangshu Feng, D. Ma, P. Yin, Xinyu Wang, Shuai Hou, Yulei Hao, Jingdian Zhang, Meiying Xin, Jiachun Feng   +9 more
semanticscholar   +1 more source

Mechanisms of ATP release and signalling in the blood vessel wall [PDF]

, 2017
The nucleotide adenosine 5′-triphosphate (ATP) has classically been considered the cell's primary energy currency. Importantly, a novel role for ATP as an extracellular autocrine and/or paracrine signalling molecule has evolved over the past century and ...
Billaud, Marie, Isakson, Brant E., Lohman, Alexander W.   +2 more
core  

Connexins-Based Hemichannels/Channels and Their Relationship with Inflammation, Seizures and Epilepsy

International Journal of Molecular Sciences, 2019
Connexins (Cxs) are a family of 21 protein isoforms, eleven of which are expressed in the central nervous system, and they are found in neurons and glia.
L. Medina-Ceja, J. C. Salazar-Sánchez, Jorge Ortega-Ibarra, A. Morales-Villagrán   +3 more
semanticscholar   +1 more source

Cyclic nucleotide permeability through unopposed connexin hemichannels

Frontiers in Pharmacology, 2013
Cyclic AMP is a well-known intracellular and intercellular second messenger. The membrane permeability of such molecules has potential importance for autocrine like or paracrine-like delivery.
Virginijus eValiunas
doaj   +1 more source

Connexin 43 hemichannels protect bone loss during estrogen deficiency

Bone Research, 2019
Estrogen deficiency in postmenopausal women is a major cause of bone loss, resulting in osteopenia, osteoporosis, and a high risk for bone fracture. Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability, bone ...
Liang Ma, Rui Hua, Yi Tian, Hongyun Cheng, R. Fajardo, Joseph J Pearson, T. Guda, D. B. Shropshire, S. Gu, Jean X. Jiang   +9 more
semanticscholar   +1 more source