Results 101 to 110 of about 3,016 (188)

Molecular mechanisms of atlastin-mediated ER membrane fusion revealed by a FRET-based single-vesicle fusion assay

Scientific Reports, 2017
Homotypic fusion of endoplasmic reticulum membranes is driven by atlastin GTPases; however, the underlying mechanism remains largely unknown. Here, using a FRET-based single-vesicle fusion assay with liposomes bearing the yeast atlastin Sey1p, we ...
Kyung Tae Kim, Yeojin Moon, Yunsu Jang, Kang Taek Lee, Changwook Lee, Youngsoo Jun, Sanghwa Lee   +6 more
doaj   +1 more source

Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics

Journal of Extracellular Biology, Volume 3, Issue 11, November 2024.
Abstract The translation of pre‐clinical anti‐cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue to achieve or seek approval, setbacks are often attributed to a lack of efficacy, failure to achieve clinical endpoints, and dose‐limiting toxicities. Successful efforts have
Stephanie R. Jackson Cullison, Joseph P. Flemming, Kubra Karagoz, Peter J. Wermuth, Mỹ G. Mahoney   +4 more
wiley   +1 more source

A -shaped hemifusion diaphragm (-HD) which is generated by a stalk that has encircled a membrane pore.

, 2012
A -shaped hemifusion diaphragm (-HD) which is generated by a stalk that has encircled a membrane pore.
Helmut Grubmüller (43939), Marcus Müller (68469), Marc Fuhrmans (155264), Siewert Jan Marrink (155272), Yuliya G. Smirnova (155268), Giovanni Marelli (155260), Herre Jelger Risselada (155256)   +6 more
core   +1 more source

LASV GPC-mediated fusion progresses through a hemifusion intermediate that is blocked by lyso-lipids.

, 2021
(A) Illustration of cold-arrested (CAS, hemifusion) and lyso-lipid-arrested (LAS, pre-hemifusion) intermediates and the effect of chlorpromazine (CPZ). (B) Lipid-arrested stage of LASV fusion. GPC-expressing COS7 cells were bound to QT6 cells transfected
Ruben M. Markosyan (11402546), Fredric S. Cohen (11402549), You Zhang (522611), Mariana Marin (166104), Gregory B. Melikyan (8917142)   +4 more
core   +1 more source

Single-Virus Fusion Experiments Reveal Proton Influx into Vaccinia Virions and Hemifusion Lag Times [PDF]

, 2013
Recent studies have revealed new insights into the endocytosis of vaccinia virus (VACV). However, the mechanism of fusion between viral and cellular membranes remains unknown.
Mercer, Jason, Schmidt, F., Mercer, J., Dittrich, Petra S., Robinson, Tom, Schmidt, Florian I., Kuhn, P., Schmidt, Florian I, Dittrich, P., Dittrich, Petra S, Kuhn, Phillip, Robinson, T.   +11 more
core   +1 more source

Enhanced cholesterol-dependent hemifusion by internal fusion peptide 1 of SARS Coronavirus-2 compared to its N-terminal counterpart

, 2021
Membrane fusion is an important step for the entry of the lipid-sheathed viruses into the host cells. The fusion process is being carried out by fusion proteins present in the viral envelope.
Chakraborty, Hirak, Bhattacharjya, Surajit, Pattnaik, Gourab Prasad   +2 more
core   +1 more source

Hemifusion between Cells Expressing Hemagglutinin of Influenza Virus and Planar Membranes Can Precede the Formation of Fusion Pores that Subsequently Fully Enlarge [PDF]

, 1999
The chronological relation between the establishment of lipid continuity and fusion pore formation has been investigated for fusion of cells expressing hemagglutinin (HA) of influenza virus to planar bilayer membranes.
Cohen, Fredric S., Razinkov, Vladimir I., Melikyan, Grigory B.   +2 more
core   +1 more source

Influenza Virus-Mediated Membrane Fusion: Determinants of Hemagglutinin Fusogenic Activity and Experimental Approaches for Assessing Virus Fusion

Viruses, 2012
Hemagglutinin (HA) is the viral protein that facilitates the entry of influenza viruses into host cells. This protein controls two critical aspects of entry: virus binding and membrane fusion.
Susan Daniel, Gary R. Whittaker, Brian S. Hamilton   +2 more
doaj   +1 more source

Electric Double Layer Charge Regulation as Key Contributor to Bilayer Lipid Membrane Hemifusion Energetics

Membrane hemifusion, defining the merging of proximal lipid leaflets preceding complete membrane fusion, represents a crucial intermediate step in cell-to-cell interaction, viral entry and drug delivery.
Valentina Wieser, Hsiu-Wei Cheng, Shang-Jun Ting, Yu-Sheng Lin   +3 more
core   +1 more source

The structure of Herpesvirus Fusion Glycoprotein B-Bilayer Complex reveals the protein-membrane and lateral protein-protein interaction [PDF]

, 2013
Glycoprotein B (gB) is a key component of the complex herpesvirus fusion machinery. We studied membrane interaction of two gB ectodomain forms and present an electron cryotomography structure of the gB-bilayer complex.
Topf, Maya, Huiskonen, JT, Topf, M., Maurer, U., Whitbeck, J., Maurer, U.E., Gruenewald, Kay, Cohen, G., Cairns, T.M., Eisenberg, R.J., Huiskonen, Juha T., Whitbeck, J.C., Zeev-Ben-Mordehai, T, Cohen, Gary H., Cohen, GH, Cairns, Tina M., Hannah, BP, Hannah, B.P., Cohen, G.H., Pandurangan, A., Zeev-Ben-Mordehai, T., Grünewald, K, Eisenberg, Roselyn J., Cairns, T., Huiskonen, J.T., Maurer, Ulrike E., Grünewald, Kay, Eisenberg, RJ, Topf, M, Grünewald, K., Maurer, UE, Pandurangan, Arun Prasad, Whitbeck, JC, Zeev-Ben-Mordehai, Tzviya, Huiskonen, J., Hannah, Brian P., Hannah, B., Pandurangan, Arun, Pandurangan, AP, Eisenberg, R., Whitbeck, J. Charles, Cairns, TM   +41 more
core   +2 more sources