Results 91 to 100 of about 3,016 (188)

The Lassa Virus Stable Signal Peptide Undergoes a Conformational Change to Aid Viral Fusion

Chemistry – A European Journal, Volume 31, Issue 18, March 25, 2025.
The unique stable signal peptide (SSP) of the Lassa virus glycoprotein complex undergoes a conformational change during pH‐dependent viral fusion. This revels a potential mechanism by which the enigmatic SSP influences the fusion process through interactions it makes with the fusion protein, glycoprotein 2 (GP2).
Shane D. Collins, Liqun Jiang, Yanxin Liu, Jinwoo Lee   +3 more
wiley   +1 more source

Fusion of mature HIV-1 particles leads to complete release of a gag-GFP-based content marker and raises the intraviral pH. [PDF]

PLoS ONE, 2013
By imaging the release of a GFP-based viral content marker produced upon virus maturation, we have previously found that HIV-1 fuses with endosomes.
Sergi Padilla-Parra, Mariana Marin, Nivriti Gahlaut, Rolf Suter, Naoyuki Kondo, Gregory B Melikyan   +5 more
doaj   +1 more source

Membrane Fusion‐Based Drug Delivery Liposomes Transiently Modify the Material Properties of Synthetic and Biological Membranes

Small, Volume 21, Issue 12, March 26, 2025.
The table of content summarizes the main development and findings of this study. Fusion of small liposomes with acceptor model or biomembranes modify the material properties of these membranes. In sketch 1, several liposomes interacting with an acceptor model vesicle. A single fusion event is shown and highlighted in sketch 2, showing lipid and content
Jayna Hammond, Ceri J. Richards, YouBeen Ko, Thijs Jonker, Christoffer Åberg, Wouter H. Roos, Rafael B. Lira   +6 more
wiley   +1 more source

Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc. [PDF]

PLoS Neglected Tropical Diseases, 2016
Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope membrane with host cell membranes.
Gonzalo P Barriga, Fernando Villalón-Letelier, Chantal L Márquez, Eduardo A Bignon, Rodrigo Acuña, Breyan H Ross, Octavio Monasterio, Gonzalo A Mardones, Simon E Vidal, Nicole D Tischler   +9 more
doaj   +1 more source

Exploring TMPRSS2 Drug Target to Combat Influenza and Coronavirus Infection

Scientifica, Volume 2025, Issue 1, 2025.
Respiratory viral infections, including influenza and coronaviruses, present significant health risks worldwide. The recent COVID‐19 pandemic highlights the urgent need for novel and effective antiviral agents. The host cell protease, transmembrane serine protease 2 (TMPRSS2), facilitates viral pathogenesis by playing a critical role in viral invasion ...
Krishnaprasad Baby, Megh Pravin Vithalkar, Somasish Ghosh Dastidar, Chiranjay Mukhopadhyay, Rania Hamdy, Sameh S. M. Soliman, Yogendra Nayak, Satish Rojekar   +7 more
wiley   +1 more source

Enhanced Tumor‐Targeted Delivery of Arginine‐Rich Peptides via a Positive Feedback Loop Orchestrated by Piezo1/integrin β1 Signaling Axis

Advanced Science, Volume 11, Issue 42, November 13, 2024.
Arginine‐rich peptides facilitate targeted‐delivery by forming hydrogen bonds with integrin β1 and promoting its recycling from cytoplasm to membrane. The Piezo1/integrin β1 signaling axis enhances cellular uptake and transport of peptides through increasing membrane fusion and Ca2+ releasing, which ultimately establishes a positive feedback loop ...
Minghai Ma, Xing Li, Minxuan Jing, Pu Zhang, Mengzhao Zhang, Lu Wang, Xiao Liang, Yunzhong Jiang, Jianpeng Li, Jiale He, Xinyang Wang, Min Lin, Lei Wang, Jinhai Fan   +13 more
wiley   +1 more source

Proposed of model of how a denatured protein can induce membrane hemifusion without proceeding through a stalk intermediate.

, 2013
The model postulates that denatured proteins (represented as orange randomly shaped curves), and perhaps other amphpathic macromolecules, can induce hemifusion by binding to two membranes (A), accumulating at the membrane-membrane interface (B), and ...
Lijing Su (348548), Alpay B. Seven (348547), Josep Rizo (43675), Yi Xu (131145), Qiu-Xing Jiang (348549)   +4 more
core   +1 more source

The synaptotagmin juxtamembrane domain is involved in neuroexocytosis

FEBS Open Bio, 2015
Synaptotagmin is a synaptic vesicle membrane protein which changes conformation upon Ca2+ binding and triggers the fast neuroexocytosis that takes place at synapses.
Paola Caccin, Michele Scorzeto, Nunzio Damiano, Oriano Marin, Aram Megighian, Cesare Montecucco   +5 more
doaj   +1 more source

Induction of aggregation and fusion of cholesterol-containing membrane vesicles by an anti-cholesterol monoclonal antibody

Journal of Lipid Research, 2000
A monoclonal IgM antibody that reacts with cholesterol was able to aggregate small and large unilamellar lipid vesicles. Vesicles aggregated by the antibody could be dispersed by trypsin digestion. Inclusion of unsaturated phosphatidylethanolamine in the
Aitziber Agirre, Shlomo Nir, José L. Nieva, Jan Dijkstra   +3 more
doaj   +1 more source

Monocyte‐derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF‐β1

Journal of Extracellular Vesicles, Volume 13, Issue 11, November 2024.
Abstract During cell invasion, large Extracellular Vesicle (lEV) release from host cells was dose‐dependently triggered by Trypanosoma cruzi metacyclic trypomastigotes (Mtr). This lEV release was inhibited when IP3‐mediated Ca2+ exit from the ER and further Ca2+ entry from plasma membrane channels was blocked, but whilst any store‐independent Ca2 ...
Ephraim A. Ansa‐Addo, Paras Pathak, Maria V. McCrossan, Izadora Volpato Rossi, Mahamed Abdullahi, Dan Stratton, Sigrun Lange, Marcel I. Ramirez, Jameel M. Inal   +8 more
wiley   +1 more source