Hemopexin and HO-1 induction during acute colitis in mice is dependent on interleukin-22 [PDF]
Frontiers in ImmunologyIntroductionInflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract that frequently requires long-term immunosuppressive therapy, which increases the risk of infections and other complications.
Ayodeji Samuel Ajayi +5 more
doaj +2 more sources
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction [PDF]
PLoS ONE, 2018 During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
John D Belcher +2 more
exaly +2 more sources
The association of hemopexin, muscle quality, and sarcopenia in Japanese older adults with cognitive impairment: a cross-sectional study [PDF]
BMC GeriatricsObjective To examine the cross-sectional associations of hemopexin, muscle quality, and sarcopenia status with cognitive function among older Japanese adults with cognitive impairment, and to explore the potential sex-specific differences.
Derong Zeng +7 more
doaj +2 more sources
Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models [PDF]
Frontiers in PhysiologyMaintaining hemopexin (HPX) plasma levels protects against heme-activated inflammation as well as the toxicity of heme and its iron during hemolysis. Plasma heme regulates HPX turnover in hepatocytes, thus controlling plasma HPX concentration.
Bryan Rose +7 more
doaj +2 more sources
Targeting HMGB1 in endothelial cells reverses heme-induced SIRS after radiofrequency ablation of hepatic hemangioma [PDF]
Frontiers in ImmunologyBackgroundAlthough radiofrequency ablation (RFA) is a safe and effective treatment for hepatic hemangiomas, post-RFA systemic inflammatory response syndrome (SIRS) frequently occurs.
Changyu Yao +9 more
doaj +2 more sources
Editorial: Heme physiology and pathology [PDF]
Frontiers in PhysiologyElena Di Pierro, Tiago L. Duarte
doaj +2 more sources
The heme scavenger hemopexin protects against lung injury during aspergillosis by mitigating release of neutrophil extracellular traps [PDF]
JCI InsightInvasive aspergillosis is characterized by lung hemorrhage and release of extracellular heme, which promotes fungal growth. Heme can also mediate tissue injury directly, and both fungal growth and lung injury may induce hemorrhage.
Ganlin Qu +9 more
doaj +2 more sources
PLoS ONE, 2020 Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of ...
Lina Youssef +8 more
doaj +2 more sources
Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake. [PDF]
PLoS ONE, 2013 PURPOSE:The body concentration of iron is regulated by a fine equilibrium between absorption and losses of iron. Iron can be absorbed from diet as inorganic iron or as heme.
Veronica Fiorito +5 more
doaj +1 more source
Frontiers in Immunology, 2022 Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma.
Alexandra Gerogianni +20 more
doaj +1 more source