Results 11 to 20 of about 6,249 (178)

Hemopexin and Cancer [PDF]

International Journal of Molecular Sciences, 2022
Hemopexin is the plasma protein with the highest affinity for heme. Seminal studies have highlighted its role in different kinds of heme-associated disorders, but its implication in cancer has been neglected for a long time. Considering the emerging importance of heme in tumors, the present review proposes an update of the works investigating hemopexin
Fiorito V., Tolosano E.
openaire   +2 more sources

Sutimlimab in Patients With Cold Agglutinin Disease (CAD): Results From a Managed Access Program. [PDF]

Eur J Haematol
ABSTRACT Cold agglutinin disease (CAD) is a low‐grade lymphoproliferative disorder accounting for 15%–30% of patients suffering from autoimmune hemolytic anemias. The clonal B cells produce autoantibodies primarily of the IgM‐κ class that cause agglutination of red blood cells (RBCs) at temperatures ≤ 37°C and activate the classical complement pathway ...
Frey SM, Halberstadt P, Alashkar F, Lenz V, Reinhardt HC, Röth A.   +5 more
europepmc   +2 more sources

The Renal Activity Index for Lupus Identifies Active Renal Disease and Treatment Response in Adult Patients With Systemic Lupus Erythematosus and Lupus Nephritis. [PDF]

Arthritis Care Res (Hoboken)
Objective We evaluated the ability of the Renal Activity Index for Lupus (RAIL) to discriminate active lupus nephritis (LN) in adult patients with active systemic lupus erythematosus (SLE) and differentiate LN treatment response. Methods Urine samples from adults with biopsy‐proven active class III and IV LN from TULIP‐LN (active LN group ...
Brunner HI, Cody EM, Devarajan P, Huang B, Chen C, Sinibaldi D, Ramaswamy M, Knagenhjelm J, Jones F, Brohawn PZ, Tummala R, Lindholm C, White WI.   +12 more
europepmc   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation

Frontiers in Immunology, 2020
Hemopexin is the main plasmatic scavenger of cell-free heme, released in the context of intravascular hemolysis or major cell injury. Heme is indispensable for the oxygen transport by hemoglobin but when released outside of the erythrocytes it becomes a ...
Victoria Poillerat, Thomas Gentinetta, Juliette Leon, Andreas Wassmer, Monika Edler, Carine Torset, Dandan Luo, Gerald Tuffin, Lubka T. Roumenina   +8 more
doaj   +1 more source

Hemopexin: anti-inflammatory, pro-inflammatory, or both? [PDF]

Journal of Leukocyte Biology, 2010
Abstract Comment on Fink Editorial: premature to label Hx as an anti-inflammatory molecule? Are we ignoring its potential pleiotropic nature?
Bakker, W. W., Melgert, B. N., Faas, M. M.   +2 more
openaire   +1 more source

Free Fetal Haemoglobin in Severe Early-Onset Fetal Growth Restriction: A Prospective Multi-Centre Study. [PDF]

BJOG
ABSTRACT Objective To assess fetal circulating free fetal haemoglobin (fHbF) levels and heme defences, correlated to fetal circulatory biometry and fetal sex in severe early‐onset fetal growth restriction (FGR). Design, Setting and Population A prospective study severe early‐onset fetal growth restriction pregnancies with close clinical management ...
Brook A, Baynes G, Scargill J, Evangelinos A, Brennan-Richardson C, Dow F, Ginsberg Y, Weissbach T, Brodszki J, Hansson E, Diemert A, Hecher K, Maksym K, Marlow N, Spencer RN, David AL, Hansson SR, Brownbill P.   +17 more
europepmc   +2 more sources

Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity

Cell Reports, 2021
Summary: Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation of skeletal muscle function at the molecular level after exercise remains unclear.
Rodrigo W. Alves de Souza, David Gallo, Ghee Rye Lee, Eri Katsuyama, Alexa Schaufler, Janick Weber, Eva Csizmadia, George C. Tsokos, Lauren G. Koch, Steven L. Britton, Ulrik Wisløff, Patricia C. Brum, Leo E. Otterbein   +12 more
doaj   +1 more source

Quality Assessment of Selected Protein Structures Derived from Homology Modeling and AlphaFold

Pharmaceuticals, 2023
With technology advancing, many prediction algorithms have been developed to facilitate the modeling of inherently dynamic and flexible macromolecules such as proteins.
Furkan Ayberk Binbay, Dhruv Chetanbhai Rathod, Ajay Abisheck Paul George, Diana Imhof   +3 more
doaj   +1 more source

Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

Molecular Medicine, 2016
Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activity ...
Tian Lin, Jialin Liu, Feng Huang, Tjitske S R van Engelen, Sujatha R Thundivalappil, Frank E Riley, Michael Super, Alexander L Watters, Ann Smith, Nathan Brinkman, Donald E Ingber, H Shaw Warren   +11 more
doaj   +1 more source