Results 21 to 30 of about 6,249 (178)
Frontiers in Immunology, 2023 It is now understood that hemolysis and the subsequent release of heme into circulation play a critical role in driving the progression of various diseases.
Yijin Li +4 more
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Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli
Current Issues in Molecular Biology, 2021 In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to ...
Maria G. Detsika, Elias A. Lianos
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Biochemistry and Biophysics Reports, 2017 Proinflammatory cytokines, including TNF-α and IL-6, can contribute to insulin resistance. Conversely, insulin has some actions that can be considered anti-inflammatory.
J. Lee Franklin +2 more
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Heme‐hemopexin: A ‘Chronosteric’ heme‐protein [PDF]
IUBMB Life, 2007 AbstractHemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four‐bladed β‐propeller domains, resembling two thick disks that lock together at a 90° angle. The heme is bound between the two β‐propeller domains in a pocket formed by the interdomain linker peptide.
ASCENZI P, FASANO, MAURO
openaire +4 more sources
Frontiers in Immunology, 2020 Shiga-toxin (Stx)-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is one of the most common causes of acute kidney injury in children.
Kioa L. Wijnsma +10 more
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Protease activity of plasma hemopexin [PDF]
Kidney International, 2005 Previous studies into the relevance of a putative circulating factor in the pathogenesis of minimal change nephrotic syndrome have opened the possibility that plasma hemopexin might be an important effector molecule in this disorder. Thus, intra renal infusion of isolated plasma hemopexin into rats induced minimal change like glomerular lesions and ...
Bakker, WW +6 more
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PLoS ONE, 2020 Pancreatic ductal adenocarcinoma is one of the most aggressive types of cancer. Certain proteins in the tumor microenvironment have attracted considerable attention owing to their association with tumor invasion and metastasis.
Yukie Suzuki +17 more
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TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins
Frontiers in Immunology, 2020 Toll-like receptors (TLRs), also known as pattern recognition receptors, respond to exogenous pathogens and to intrinsic danger signals released from damaged cells and tissues.
Sabina Janciauskiene +2 more
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Molecules, 2022 Development of high throughput robust methods is a prerequisite for a successful clinical use of LC-MS/MS assays. In earlier studies, we reported that nLC-MS/MS measurement of the O-glycoforms of HPX is an indicator of liver fibrosis.
Aswini Panigrahi +5 more
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Frontiers in Immunology, 2018 Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme.
Alessandra Mozzi +5 more
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