Results 31 to 40 of about 6,249 (178)

Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis

Frontiers in Immunology, 2018
Intravascular erythrocyte destruction, accompanied by the release of pro-oxidative and pro-inflammatory components hemoglobin and heme, is a common event in the pathogenesis of numerous diseases with heterogeneous etiology and clinical features.
Nicolas S. Merle, Nicolas S. Merle, Nicolas S. Merle, Anne Grunenwald, Anne Grunenwald, Anne Grunenwald, Marie-Lucile Figueres, Marie-Lucile Figueres, Marie-Lucile Figueres, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Marie Daugan, Marie Daugan, Marie Daugan, Samantha Knockaert, Samantha Knockaert, Samantha Knockaert, Tania Robe-Rybkine, Tania Robe-Rybkine, Tania Robe-Rybkine, Remi Noe, Remi Noe, Remi Noe, Olivia May, Olivia May, Olivia May, Marie Frimat, Marie Frimat, Nathan Brinkman, Thomas Gentinetta, Sylvia Miescher, Pascal Houillier, Pascal Houillier, Pascal Houillier, Veronique Legros, Florence Gonnet, Olivier P. Blanc-Brude, Olivier P. Blanc-Brude, Marion Rabant, Regis Daniel, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina   +47 more
doaj   +1 more source

Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline

Frontiers in Molecular Biosciences, 2020
Brain iron dyshomeostasis is a feature of Alzheimer's disease. Conventionally, research has focused on non-heme iron although degradation of heme from hemoglobin subunits can generate iron to augment the redox-active iron pool.
Azhaar A. Ashraf, Melanie Dani, Po-Wah So   +2 more
doaj   +1 more source

What Is Next in This “Age” of Heme-Driven Pathology and Protection by Hemopexin? An Update and Links with Iron

Pharmaceuticals, 2019
This review provides a synopsis of the published literature over the past two years on the heme-binding protein hemopexin (HPX), with some background information on the biochemistry of the HPX system.
Luis Montecinos, Jeffrey D. Eskew, Ann Smith   +2 more
doaj   +1 more source

Free heme exacerbates colonic injury induced by anti-cancer therapy

Frontiers in Immunology, 2023
Gastrointestinal inflammation and bleeding are commonly induced by cancer radiotherapy and chemotherapy but mechanisms are unclear. We demonstrated an increased number of infiltrating heme oxygenase-1 positive (HO-1+) macrophages (Mø, CD68+) and the ...
Philippa Seika, Monika Janikova, Monika Janikova, Sahana Asokan, Sahana Asokan, Sahana Asokan, Lubica Janovicova, Lubica Janovicova, Eva Csizmadia, Mckenzie O’Connell, Simon C. Robson, Jonathan Glickman, Barbara Wegiel   +12 more
doaj   +1 more source

Growth inhibition of Bacteroides fragilis by hemopexin: proteolytic degradation of hemopexin to overcome heme limitation [PDF]

FEMS Microbiology Letters, 2001
The stimulatory effect of heme on growth of Bacteroides fragilis, an anaerobic human pathogen, was strongly inhibited by hemopexin, an avid ...
E R, Rocha, A, Smith, C J, Smith, J H, Brock   +3 more
openaire   +2 more sources

Prediction of Intact N-Glycopeptide Retention Time Windows in Hydrophilic Interaction Liquid Chromatography

Molecules, 2022
Analysis of protein glycosylation is challenging due to micro- and macro-heterogeneity of the attached glycans. Hydrophilic interaction liquid chromatography (HILIC) is a mode of choice for separation of intact glycopeptides, which are inadequately ...
Petr Kozlik, Katarina Molnarova, Tomas Jecmen, Tomas Krizek, Zuzana Bosakova   +4 more
doaj   +1 more source

Spatial transcriptome data from coronal mouse brain sections after striatal injection of heme and heme-hemopexin

Data in Brief, 2022
Hemorrhagic stroke is a major cause of morbidity and mortality worldwide. Secondary mechanisms of brain injury adversely affect functional outcome in patients after intracranial hemorrhage.
Kevin Akeret, Michael Hugelshofer, Dominik J. Schaer, Raphael M. Buzzi   +3 more
doaj   +1 more source

Strongyloidiasis stercoralis coinfection is associated with altered iron status biomarkers in tuberculous lymphadenitis

Frontiers in Immunology, 2022
Soil-transmitted helminth [mainly Strongyloidiasis stercoralis (Ss)] and tuberculous lymphadenitis (TBL) coinfection in humans is a significant public health problem. We have previously shown that TBL+Ss+ coinfection significantly alters diverse cytokine,
Gokul Raj Kathamuthu, Gokul Raj Kathamuthu, Anuradha Rajamanickam, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu, Subash Babu   +6 more
doaj   +1 more source

Use of hemopexin domains and monoclonal antibodies to hemopexin to probe the molecular determinants of hemopexin-mediated heme transport.

Journal of Biological Chemistry, 1988
Plasmin cleaves rabbit serum apohemopexin (Mr = 60,000) at a single site producing a heme-binding domain (I, Mr = 35,000) and a second domain (II, Mr = 25,000) (W. T. Morgan and A. Smith (1984) J. Biol. Chem. 259, 12001-12005). The absorbance spectra of heme-domain I are indicative of a bis-histidyl coordination complex with the central heme iron atom.
W T, Morgan, P, Muster, F M, Tatum, J, McConnell, T P, Conway, P, Hensley, A, Smith   +6 more
openaire   +2 more sources

Hierarchical Channeled Graphitized Nanoarchitecture as a Diagnostic Platform for Maternal Fever Warning

Advanced Science, EarlyView.
This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin, Ning Li, Heyuhan Zhang, Xufang Hu, Zhiqiang Liu, Chunhui Deng   +5 more
wiley   +1 more source