Results 61 to 70 of about 6,249 (178)

An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors

Stem Cell Reports, 2017
Hematopoietic stem cells (HSCs) are considered one of the most promising therapeutic targets for the treatment of various blood disorders. However, due to difficulties in establishing stable maintenance and expansion of HSCs in vitro, their insufficient ...
Aki Ieyasu, Reiko Ishida, Takaharu Kimura, Maiko Morita, Adam C. Wilkinson, Kazuhiro Sudo, Toshinobu Nishimura, Jun Ohehara, Yoko Tajima, Chen-Yi Lai, Makoto Otsu, Yukio Nakamura, Hideo Ema, Hiromitsu Nakauchi, Satoshi Yamazaki   +14 more
doaj   +1 more source

Plasma Hemopexin Activity in Pregnancy and Preeclampsia

Hypertension in Pregnancy, 2007
Plasma hemopexin activity, associated with increased vascular permeability, was evaluated in healthy pregnant and non-pregnant women and in pre-eclamptic women.Hemopexin activity and the hemopexin inhibitor, extracellular ATP, were assayed in plasma from pregnant (n = 10), preeclamptic (n = 9), and non-pregnant women (n = 10) using standard methods ...
Bakker, Winston W., Donker, Rogier B., Timmer, Albertus, van Pampus, Marielle G., van Son, Willem J., Aarnoudse, Jan G., van Goor, Harry, Niezen-Koning, Klary E., Navis, Gerjan, Borghuis, Theo, Jongman, Rianne M., Faas, Marijke M.   +11 more
openaire   +2 more sources

Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding

Oral Diseases, EarlyView.
ABSTRACT Objective This observational, cross‐sectional, and analytical study aimed to explore the pathophysiological mechanisms of gingivitis in pregnancy by analyzing the salivary proteomic profile according to gingival bleeding status. Materials and Methods Pregnant women at the 27th week of gestation or beyond were categorized into two groups: those
Gerson Aparecido Foratori‐Junior, Clovis Bergamin Griso, Amanda Borges Pirondi, Laura Teodoro de Marchi, Talita Mendes Oliveira Ventura, Larissa Tercilia Grizzo, Roosevelt da Silva Bastos, Alejandra Chaparro, Nagihan Bostanci, Marília Afonso Rabelo Buzalaf   +9 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Isolation of feline plasma hemopexin.

The Japanese Journal of Veterinary Science, 1984
Feline hemopexin (Hx) was isolated from serum with the procedure on the modification of Vretblad et al.. Purified Hx had 71, 000 and 74, 000 dalton at 4-30% PAGE, and the solution immunized to rabbit foot pad. After 3 weeks, only one precipitate was observed between feline plasma and antiserum with IEP and Ouchtalony method.
T, Furukawa, F, Sugiyama
openaire   +3 more sources

Intranasal Human NSC‐Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS‐STING Signalling, in Aged Hippocampus

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT Neuroinflammaging, a moderate, chronic, and sterile inflammation in the hippocampus, contributes to age‐related cognitive decline. Neuroinflammaging comprises the activation of the nucleotide‐binding domain, leucine‐rich repeat family, and pyrin domain‐containing 3 (NLRP3) inflammasomes, and the cyclic GMP‐AMP synthase (cGAS)‐stimulator of ...
Leelavathi N. Madhu, Maheedhar Kodali, Shama Rao, Sahithi Attaluri, Raghavendra Upadhya, Goutham Shankar, Bing Shuai, Yogish Somayaji, Shruthi V. Ganesh, Vignesh S. Kumar, Jeswin E. James, Padmashri A. Shetty, Avery LeMaire, Xiaolan Rao, James J Cai, Ashok K. Shetty   +15 more
wiley   +1 more source

Interaction of rabbit hemopexin with rose bengal and photooxidation of the rose bengal-hemopexin complex

Journal of Biological Chemistry, 1975
Rabbit hemopexin associates with rose bengal producing a hypochromic shift in the absorption spectrum of the dye; the extinction coefficient of the dye bound to heme-saturated hemopexin is approximately 20% lower than that of the dye bound to the apoprotein.
V L, Seery, W T, Morgan, U, Muller-Eberhard   +2 more
openaire   +2 more sources

Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa, Anne‐Katrin Rohlfing, Ravi Hochuli, Pamela Weronika Sowa, Tatsiana Castor, Meinrad Paul Gawaz   +5 more
wiley   +1 more source

Interleukin-4, hemopexin, and lipoprotein-associated phospholipase A2 are significantly increased in patients with unstable carotid plaque

Open Chemistry, 2019
This study aimed to compare the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2), hemopexin (Hpx), and interleukin-4 (IL-4) in patients with carotid artery atherosclerosis based on neurological symptoms and plaque histopathology and to ...
Stefanic Peter, Sihotsky Vladimir, Hertelyova Zdenka, Kopolovets Ivan, Mathews Abraham John, Toth Stefan, Kubikova Maria, Svajdler Peter, Mucha Rastislav, Vasko Lukas, Virag Michal, Pribula Vit, Pella Dominik, Frankovicova Maria   +13 more
doaj   +1 more source

Characterization and Comparison of Milk Fat Globule Membrane Proteins, Whey Protein Concentrate, and Micellar Casein Concentrate

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study compared milk fat globule membrane protein (MFGMP) with whey protein concentrate (WPC) and micellar casein concentrate (MCC). The results revealed MFGMP's superior structural stability and amino acid profile, identified its unique proteomic landscape through label‐free quantification, and demonstrated its enhanced in vitro digestibility ...
Jiaming Wang, Xiaoguo Ji, Zhongbo Bian, Yuwei Liu, Wenliang Chen, Chuang Fan, Juan Li   +6 more
wiley   +1 more source