Results 111 to 120 of about 465,990 (261)
BiologicsHeparan sulfate proteoglycans are highly glycosylated proteins in which heparan sulfate, a glycosaminoglycan sugar chain, is an acidic sugar chain consisting of a repeating disaccharide structure of glucuronic acid and N-acetylglucosamine is locally ...
Yasunari Matsuzaka, Ryu Yashiro
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.The power of time‐of‐flight secondary ion mass spectrometry‐partial least square regression to detect interleukin‐8, a chemokine involved in inflammation and cancer, down to mass fractions of 1 ppm within biopolymer matrices, including Matrigel and glycosaminoglycan‐based hydrogels, is demonstrated.
Ralf Zimmermann +4 more
wiley +1 more source
Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis. [PDF]
, 2009 Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional ...
Iozzo, Renato V +2 more
core +2 more sources
Instant determination of the potential biomarker heparan sulfate in human plasma by a mix-and-read fluorescence assay [PDF]
arXiv, 2017 Heparan sulfate (HS) is a linear, polydisperse sulfated polysaccharide belonging to the glycosaminoglycan family. HS proteoglycans are ubiquitously found at the cell surface and extracellular matrix in animal species. HS is involved in the interaction with a wide variety of proteins and the regulation of many biological activities.
arxiv
Involvement of heparanase in the pathogenesis of acute kidney injury: Nephroprotective effect of PG545 [PDF]
, 2017 Despite the high prevalence of acute kidney injury (AKI) and its association with increased morbidity and mortality, therapeutic approaches for AKI are disappointing. This is largely attributed to poor understanding of the pathogenesis of AKI. Heparanase,
Abassi, Zaid +16 more
core +1 more source
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? [PDF]
Brazilian Journal of Medical and Biological Research, 1999 The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative ...
H.B. Nader +14 more
doaj +1 more source
Quantification of sulfated polysaccharides in urine by the Heparin Red mix-and-read fluorescence assay [PDF]
arXiv, 2018 Quantification of sulfated polysaccharides in urine samples is relevant to pharmacokinetic studies in drug development projects and to the non-invasive diagnosis and therapy monitoring of mucopolysaccharidoses. The Heparin Red Kit is a particularly simple and user friendly fluorescence assay for the quantification of sulfated polysaccharides and has ...
arxiv
Heparan sulfate proteoglycans.
Cold Spring Harbor Perspectives in Biology, 2011 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these ...
S. Sarrazin, William C. Lamanna, J. Esko
semanticscholar +1 more source
Cell Surface Glycosaminoglycans as Receptors for Adhesion of Candida spp. to Corneal Cells
Polish Journal of Microbiology, 2022 The most common causal agents of fungal keratitis are yeasts of the Candida genus. Adhesion constitutes the first stage of pathogenesis. Previous studies have shown that glycosaminoglycans from the corneal cell surface play an essential role in bacterial
Ordiales Helena +5 more
doaj +1 more source
Engineering antibodies with cancer‐associated binding sites
BMEMat, EarlyView.This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian +4 more
wiley +1 more source