Results 201 to 210 of about 267,445 (243)
Demystifying Heparan Sulfate–Protein Interactions [PDF]
Annual Review of Biochemistry, 2014 Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors, extracellular matrix proteins, and membrane receptors, bind heparin.
Jeffrey Esko, Ding Xu
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Chemoenzymatic Design of Heparan Sulfate Oligosaccharides [PDF]
Journal of Biological Chemistry, 2010 Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides.
Qisheng Zhang, Yongmei Xu
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Heparan Sulfate Proteoglycans in Glomerular Inflammation [PDF]
Kidney International, 2004 Heparan sulfate proteoglycans (HSPGs) are glycoproteins consisting of a core protein to which linear heparan sulfate side chains are covalently attached.
Johan Van Der Vlag +2 more
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The heparitin sulfates (heparan sulfates)
Carbohydrate Research, 1973Heparitin sulfate has been isolated from several sources, namely: a commercial lung polysaccharide preparation, beef lung, beef aorta, human amyloid liver, human intestine, and urine of a patient with mucopolysaccharidosis. The polysaccharides isolated were extensively purified, fractionated, and characterized.
A, Linker, P, Hovingh
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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 [PDF]
Cell, 2020 We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD).
Kevin D Corbett +2 more
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Heparan Sulfate Signaling in Cancer [PDF]
Trends in Biochemical Sciences, 2014 Heparan sulfate (HS) is a biopolymer consisting of variably sulfated repeating disaccharide units. The anticoagulant heparin is a highly sulfated intracellular variant of HS. HS has demonstrated roles in embryonic development, homeostasis, and human disease via non-covalent interactions with numerous cellular proteins, including growth factors and ...
Gerard Conrad Blobe, Erik H Knelson
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Bioengineered Heparins and Heparan Sulfates [PDF]
Advanced Drug Delivery Reviews, 2016 Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex structures and polydispersity, are biosynthesized in the Golgi of animal cells.
Li Fu +2 more
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Heparan Sulfate Proteoglycans in Diabetes
Seminars in Thrombosis and Hemostasis, 2021AbstractDiabetes is a complex disorder responsible for the mortality and morbidity of millions of individuals worldwide. Although many approaches have been used to understand and treat diabetes, the role of proteoglycans, in particular heparan sulfate proteoglycans (HSPGs), has only recently received attention.
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Antithrombin, heparin, and heparan sulfate
Critical Care Medicine, 2002To review the experimental and clinical evidence that antithrombin has multiple mechanisms for both its anticoagulant and anti-inflammatory properties. The interaction between antithrombin and specific polysulfated, acidic oligosaccharide moieties found on heparin and related proteoglycan molecules within the circulation and on endothelial surfaces ...
Steven M, Opal +3 more
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The heparan sulfate of rat brain
Biochimica et Biophysica Acta (BBA) - General Subjects, 1972Heparan sulfate comprises 14% of the total mucopolysaccharide content of rat brain. Two heparan sulfate fractions (HS-I and HS-II) can be obtained by gradient elution from Dowex I (chloride). HS-I is eluted with i.o. M NaCl and accounts for approximately one third of the total heparan sulfate, while HS-II, accounting for the remaining two thirds of the
R U, Margolis, D M, Atherton
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