Results 181 to 190 of about 50,719 (280)

Heparanase‐Loaded CAR T Extracellular Vesicles Remodel the Colorectal Tumour Microenvironment and Boost T Cell Antitumor Immunity

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Dense ECM restricts CAR T efficacy in solid tumours. Zhu et al. design mesothelin‐targeted CAR T cells that secrete heparanase‐rich extracellular vesicles via a truncated hepatitis A virus pX domain (pX‐Δ1‐30), promoting ECM degradation, durable memory, and less exhausted phenotypes, leading to strong antitumor responses in colorectal cancer spheroids ...
Songshan Zhu, Jun Yin, Weiqiang Yang, Xin Fu, Yiwei Zeng, Na Huang, Ling Zhang, Cong Yu, Ping Ouyang, Kaisong Huang, Rui Chen, Xiaolei Zhao, Dan Jiang, Guangxian Xu   +13 more
wiley   +1 more source

Dynamic structures of dengue virus serotype 2 secreted NS1 and their interactions with heparan sulfate. [PDF]

Nat Commun
Zhou Q, Ng TS, Suthershinii G, Tan AWK, Kostyuchenko VA, Fibriansah G, Lok SM.   +6 more
europepmc   +1 more source

Functional dissection of the prototype foamy virus glycoprotein heparan sulfate binding site. [PDF]

Retrovirology
Büttrich M, Stanke-Scheffler N, Calcraft T, Rosenthal PB, Lindemann D.   +4 more
europepmc   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Antiviral Activity of Dendritic Heparan Sulfate Mimetics against Respiratory Syncytial Virus and Herpes Simplex Virus‑1. [PDF]

ACS Omega
Yue Y, Chang A, Spijkers-Shaw S, Devlin R, Li Y, Rendle PM, Nutsford A, Sullivan-Hill B, Wang C, Zubkova OV, Netzler NE, Taylor JA.   +11 more
europepmc   +1 more source

Heparanase inhibition prevents glycocalyx damage and albuminuria in experimental minimal change disease

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Michael Crompton, Raina D. Ramnath, Kai Betteridge, Sara Desideri, Aldara Martin Alonso, Lulu Jiang, Monica Gamez, Holly Stowell‐Connolly, Viktoriia Vasylchenko, Karen L. Onions, Matthew J. Butler, Chris R. Neal, Andrew H. J. Salmon, Jeremy E. Turnbull, Hiroshi Kawachi, Olga V. Zubkova, Gavin I. Welsh, Simon C. Satchell, Rebecca R. Foster   +18 more
wiley   +1 more source

Fully Synthetic, Biomimicking Polysulfates With Tunable Anticoagulant and Endothelial Cell–Selective Bioactivity

Macromolecular Bioscience, Volume 26, Issue 6, June 2026.
Sulfated PHEMA‐based polyelectrolyte brushes are introduced as a reductionist platform to probe glycosaminoglycan‐inspired bioactivity. High charge density governs growth factor interactions and is associated with distinct vascular cell responses, enabling balanced endothelial and smooth muscle cell co‐culture.
Andrea Cosimi, Roxana Pollehn, Andrea De Martino, Scarlett Manzke, Yannic Kerkhoff, Philip Nickl, Theresa Lohmann, Eriselda Keshi, Cornelia Lee‐Thedieck, Marie Weinhart   +9 more
wiley   +1 more source

Heparan Sulfate Proteoglycans (HSPGs) and Their Degradation in Health and Disease. [PDF]

Biomolecules
Greco N, Masola V, Onisto M.
europepmc   +1 more source

From 2D to 3D Bioprinted In Vitro Breast Cancer Model: A Comparative Study of Proliferation, Tissue Structure, and mTOR Signaling

MedComm, Volume 7, Issue 6, June 2026.
A 3D bioprinted breast cancer model was created to more accurately reproduce in vivo tumor characteristics compared to conventional 2D cultures. Distinct cell adhesion patterns, reduced mTOR signaling, and altered drug responses were observed under 3D conditions.
Dorottya Moldvai, Gábor Petővári, Rebeka Gelencsér, Dániel Sztankovics, Risa Miyaura, Viktória Varga, Fatime Szalai, Kornélia Baghy, Ildikó Krencz, Titanilla Dankó, Anna Sebestyén   +10 more
wiley   +1 more source

The essential role of heparan sulfate in the entry of PDCoV and other porcine coronaviruses. [PDF]

Virulence
Ma N, Zhang M, Ghonaim AH, Zhou P, Wang C, Zhou J, Guo G, Lebbink RJ, Bosch BJ, Zhu H, Li W, He Q.   +11 more
europepmc   +1 more source