Results 171 to 180 of about 211,407 (207)

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Artificial Catch Bonds: From Molecular Design to Network Mechanics

ChemSystemsChem, Volume 8, Issue 5, September 2026.
Catch bonds strengthen rather than weaken under force. This review follows the discovery and development of our understanding of this counterintuitive phenomenon, from the molecular mechanisms that produce it to the design rules for engineering it in DNA, proteins, and polymers, and on to the collective network mechanics enabling materials that stiffen
Hengfeng Jiang, Micah Yang, Isaac T. S. Li   +2 more
wiley   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, Volume 143, Issue 5, Page 625-638, September 2026.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

Angiopoietin‐like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride‐rich lipoproteins in humans

Journal of Internal Medicine, Volume 300, Issue 3, Page 312-328, September 2026.
Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca, Elias Björnson, Laura D'Erasmo, Alessia Di Costanzo, Simone Bini, Ilenia Minicocci, Daniele Tramontano, Stella Covino, Giuseppe Ciarlo, Manuela Lombardi, Sanni Söderlund, Niina Matikainen, Linda Andersson, Martin Adiels, Marja‐Riitta Taskinen, Chris J. Packard, Jan Borén   +16 more
wiley   +1 more source

Scavenger Receptor Class F Member 2: An Intracellular Receptor Escorting Hepatitis B Virus From Endosome to Nuclear Pore

MedComm – Future Medicine, Volume 5, Issue 3, September 2026.
Yujing Ng, Lin Du, Huahao Fan
wiley   +1 more source

Understanding neurodegeneration and regeneration in the CNS: New concepts, clinical investigations, and an unsung hero of neuroscience

Neuroprotection, Volume 4, Issue 3, Page 191-194, September 2026.
Piotr Walczak, Shen Li, Xunming Ji, Johannes Boltze   +3 more
wiley   +1 more source

Heparan sulfate proteoglycans in glomerular inflammation [PDF]

Kidney International, 2004
Heparan sulfate proteoglycans (HSPGs) are glycoproteins consisting of a core protein to which linear heparan sulfate side chains are covalently attached.
Johan van der Vlag, Toin van Kuppevelt, Lambertus van den Heuvel   +2 more
exaly   +4 more sources

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides* [PDF]

Journal of Biological Chemistry, 2010
Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides.
Qisheng Zhang, Yongmei Xu
exaly   +2 more sources

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The heparitin sulfates (heparan sulfates)

Carbohydrate Research, 1973
Heparitin sulfate has been isolated from several sources, namely: a commercial lung polysaccharide preparation, beef lung, beef aorta, human amyloid liver, human intestine, and urine of a patient with mucopolysaccharidosis. The polysaccharides isolated were extensively purified, fractionated, and characterized.
A, Linker, P, Hovingh
openaire   +2 more sources