Results 151 to 160 of about 211,407 (207)

The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer

Breast Cancer Research
Background Breast cancer, one of the most common forms of cancer, is associated with the highest cancer-related mortality among women worldwide. In comparison to other types of breast cancer, patients diagnosed with the triple-negative breast cancer ...
Jasmine M. Manouchehri, Jharna Datta, Lynn M. Marcho, Jesse J. Reardon, Daniel Stover, Robert Wesolowski, Uma Borate, Ting-Yuan David Cheng, Patrick M. Schnell, Bhuvaneswari Ramaswamy, Gina M. Sizemore, Mark P. Rubinstein, Mathew A. Cherian   +12 more
doaj   +1 more source

The Critical Role of Fractionated Urine Glycosaminoglycans in the Evaluation of Mucopolysaccharidosis Type II in Four Unrelated Families

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2110-2117, September 2026.
ABSTRACT Since 2015, Ann and Robert H. Lurie Children's Hospital has performed diagnostic testing for infants who screen positive for mucopolysaccharidosis type II (MPS II) on the Illinois newborn screen. Preliminary diagnostic testing includes measurement of plasma iduronate‐2‐sulfatase enzyme activity and urinary glycosaminoglycan analysis, followed ...
Carly A. Rasmussen, Monika Izdebski, Allison Paltzer, Rachel Hickey, Laura Pollard, Joshua Baker   +5 more
wiley   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Effect of heparan sulfate and gold nanoparticles on muscle development during embryogenesis

, 2011
Marlena Zielinska1,2, Ewa Sawosz1, Marta Grodzik1, Mateusz Wierzbicki1, Maria Gromadka1, Anna Hotowy3, Filip Sawosz3, Andrzej Lozicki1, Andrè Chwalibog31Division of Biotechnology and Biochemistry of Nutrition, Warsaw University of Life ...
Sawosz E, Sawosz F, Zielinska M, Gromadka M, Chwalibog A, Grodzik M, Hotowy A, Lozicki A, Wierzbicki M   +8 more
core  

Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Lysosomal dysfunction contributes to Alzheimer's disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is regulated and how it influences early AD pathophysiology.
Cynthia Picard, Gabriel Aumont‐Rodrigue, Isabel Sarty, Julia Loncke, Mélissa Savard, Laurence Maligne‐Bruneau, Judes Poirier, for the PREVENT‐AD research group   +7 more
wiley   +1 more source

Regulation of Murine Splenocyte Responses by Heparan Sulfate

, 1991
Heparan sulfate is a biologically active glycosaminoglycan found in abundance in endothelium, epithelium, and connective tissues. Although heparan sulfate is an important part of the environment in which immune cells function, its effects on the immune ...
Wrenshall, Lucile E., Carlson, Ann, Bach, Fritz H., Cerra, Frank B., Platt, Jeffrey L.   +4 more
core   +2 more sources

Regulated Diversity of Heparan Sulfate [PDF]

Journal of Biological Chemistry, 1998
U, Lindahl, M, Kusche-Gullberg, L, Kjellén   +2 more
openaire   +2 more sources

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3140-3150, September 2026.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Lactoferrin and Nanotechnology: New Insights Into Glioblastoma Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Current glioblastoma multiforme (GBM) management primarily relies on surgery, chemotherapy, and radiotherapy; however, therapeutic efficacy remains limited due to tumor invasiveness and restricted drug penetration across the blood–brain barrier. Lactoferrin (LF), an iron‐binding glycoprotein with receptor‐mediated transport capability, has emerged as a
Atena Abed, Javad Amini Mahabadi
wiley   +1 more source

Circulating Serum AGRN and ADAMTS8 With Related Candidates as Potential Biomarkers for Carotid Plaque Presence and Vulnerability

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This study investigated serum AGRN and ADAMTS8 as biomarkers for carotid plaques within human participants. Results showed a significant correlation with plaque presence, yielding a moderate combined diagnostic performance. However, these markers poorly differentiated plaque vulnerability.
Shuaiwei Guo, Shengyan Cui, Xiao Zhang, Zixuan Xing, Yixin Sun, Mingqian Qin, Xiaoying Ma, Xiangyu Li, Yan Ma, Peng Gao, Yanfei Chen, Yabing Wang, Bin Yang, Jian Chen, Fei Chen, Xia Lu, Jiaqi Jin, Liqun Jiao, Tao Wang   +18 more
wiley   +1 more source