Results 91 to 100 of about 40,174 (273)

Inhibition of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis [PDF]

Journal of Biological Chemistry, 2008
Proteoglycans (PGs) are composed of a protein moiety and a complex glycosaminoglycan (GAG) polysaccharide moiety. GAG chains are responsible for various biological activities. GAG chains are covalently attached to serine residues of the core protein. The first step in PG biosynthesis is xylosylation of certain serine residues of the core protein.
Dinesh R, Garud, Vy M, Tran, Xylophone V, Victor, Mamoru, Koketsu, Balagurunathan, Kuberan   +4 more
openaire   +2 more sources

Regulation of stem cell fate by HSPGs: implication in hair follicle cycling

npj Regenerative Medicine, 2022
Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein.
Charlie Colin-Pierre, Oussama El Baraka, Louis Danoux, Vincent Bardey, Valérie André, Laurent Ramont, Stéphane Brézillon   +6 more
doaj   +1 more source

The multifaceted roles of perlecan in fibrosis [PDF]

, 2018
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a ...
Al-Ahmad, Andersson-Sjoland, Andersson-Sjoland, Arthur, Ashikari-Hada, Asplund, Aviezer, Barkefors, Barros, Behrens, Beller, Bengtsson, Bingley, Bishop, Bittencourt, Bix, Bix, Borkham-Kamphorst, Bremnes, Burgess, Cailhier, Cassiman, Celie, Ceol, Chakravarti, Chen, Chilosi, Chuang, Chuang, Cohen, Conde-Knape, Conte, Costell, Di Sario, Dos Santos, Duffield, Ebefors, Edgar, Esko, Evanko, Farach-Carson, Farach-Carson, Fengying Tang, Fernandez, Forsberg, Friedman, Friedman, Fujii, Gallai, Garl, Ge, Gellersen, Giros, Gohring, Gonzalez, Gonzalez, Goyal, Gressner, Gubbiotti, Guo, Hajari Case, Hallgren, Hammond, Hashimoto, Haubst, Hayashi, Hayward, Hedin, Hedin, Hering, Hilberg, Hisatomi, Ichimaru, Ikeguchi, Iozzo, Iozzo, Iozzo, Iredale, James G.W. Smith, James Melrose, Jelena Rnjak-Kovacina, John M. Whitelock, Jung, Kahari, Kaji, Kennett, Kinsella, Knox, Knox, Knox, Knox, Kotaru, Kovalszky, Koyama, Krimmer, Kunjathoor, Kvist, Laplante, Laplante, Leask, Leask, Leask, Lee, Lee, Lee, Lekkerkerker, Levy, Liang, Lord, Lord, Lord, Lord, Lundkvist, Mak, Mak, Mak, Malmstrom, Marra, Martinez-Hernandez, Martinez-Hernandez, Marx, Marzoll, Masola, Matsui, Matsuo, Megan S. Lord, Melrose, Melrose, Menzel, Mitra, Mollmark, Mongiat, Mongiat, Moon, Murphy, Musso, Nagy, Nakamura, Nakayama, Narita, Nguyen, Nihlberg, Nilsson, Ogawa, Ohkawara, Ozaki, Paka, Patel, Pillarisetti, Pinzani, Poluri, Pozzi, Raines, Raj, Rauch, Raymond, Rees, Rienstra, Rnjak-Kovacina, Rojkind, Rolls, Rosenzweig, Roskams, Ross, Sahin, Sakai, Salem, Sato, Schaefer, Schafer, Segev, Sharma, Shimizu-Hirota, Singh, Sofroniew, Sweeney, Tang, Tang, Tannock, Tao, Teh, Teimouri, Theret, Thomas, Thyberg, Timpl, Tomasek, Tran, Tran, Tran-Lundmark, Tátrai, Uchimura, Vanheule, Venkatesan, Venkatesan, Wang, Weiser, Weiser, Westergren-Thorsson, Westergren-Thorsson, Westergren-Thorsson, Whitelock, Whitelock, Whitelock, Whitelock, Willis, Wollin, Wollin, Woodall, Xu, Yamamoto, Yang, Yaoi, Yue, Yung, Yung, Zeisberg, Zeisberg   +217 more
core   +1 more source

Hydrogels Formed by the Self‐Assembly of Collagen‐Mimetic Peptides With a Constrained Backbone Structure

Chemistry – A European Journal, EarlyView.
Kinked collagen‐mimetic peptides (kinkCMPs), whose backbone is constrained by a disulfide bond, are designed to induce hydrogel formation. The kinked backbone promotes supramolecular assembly into tunable hydrogels with thermal stability depending on length.
Moeka Noto, Kazunori K. Fujii, Yuetsu Shu, Takashi Hiroi, Takaki Koide   +4 more
wiley   +1 more source

Bench-to-bedside review: The role of glycosaminoglycans in respiratory disease. [PDF]

, 2006
The extracellular matrix (ECM) plays a significant role in the mechanical behaviour of the lung parenchyma. The ECM is composed of a three-dimensional fibre mesh that is filled with various macromolecules, among which are the glycosaminoglycans (GAGs ...
PELOSI P.P., ROCCO PR, SOUZA-FERNANDES AB   +2 more
core   +1 more source

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Glycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6‐deficient spondylodysplastic Ehlers–Danlos syndrome

JIMD Reports, 2022
The spondylodysplastic type of Ehlers–Danlos syndrome (spEDS) is caused by genetic defects in the B4GALT7 or B3GALT6 genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan sulfate ...
Mahnaz Nikpour, Fredrik Noborn, Jonas Nilsson, Tim Van Damme, Olivier Kaye, Delfien Syx, Fransiska Malfait, Göran Larson   +7 more
doaj   +1 more source

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]

, 2017
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR, Douglass S, Kalas W, Mathiak M, Onita T, Zhu YH   +5 more
core   +2 more sources

Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis [PDF]

, 2014
Background Heparan sulfate proteoglycans (HSPG) are important for embryonic development via the regulation of gradient formation and signaling of multiple growth factors and morphogens.
Cai, Zhigang, Grobe, Kay, Zhang, Xin
core   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source