Results 1 to 10 of about 205,561 (359)
Hepatic stellate cells and parasite-induced liver fibrosis [PDF]
Parasites & Vectors, 2010 Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well ...
Li Yuesheng S +3 more
doaj +4 more sources
Thrombin and factor Xa link the coagulation system with liver fibrosis
BMC Gastroenterology, 2018 Background Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated.
Ameet Dhar +5 more
doaj +2 more sources
Hepatic-stellate-cell-targeted delivery of PU.1 decoy ODN by Apt-Tan attenuates liver fibrosis in mice [PDF]
Molecular Therapy: Nucleic AcidsTargeted therapeutics for liver fibrosis (LF) are unavailable. PU.1 is a pioneer transcription factor (TF) that promotes hepatic stellate cell (HSC) activation and LF.
Yong Tan +11 more
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β-arrestin1 activates hepatic stellate cells to promote liver fibrosis via activating p38 signaling pathway [PDF]
Xin yixue, 2023 Objective To investigate the role ofβ-arrestin1 （ARRB1） in liver fibrosis and elucidate the mechanism of hepatic stellate cell activation induced by ARRB1/p38 signaling pathway to promote liver fibrosis.
Xia Yanhao, Liu Huiling, Jiang Jie, Wu Bin
doaj +1 more source
Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis [PDF]
Clinical and Molecular Hepatology, 2020 Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed only in stellate cells and can be utilized as a marker to distinguish
Le Thi Thanh Thuy +2 more
doaj +1 more source
Nature Metabolism, 2022 Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which ...
Qi-Tao Chen +15 more
semanticscholar +1 more source
Hepatic Stellate Cell-Immune Interactions in NASH
Frontiers in Endocrinology, 2022 Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide. Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is characterized by severe hepatocellular injury, inflammation, and fibrosis. Chronic
James K. Carter, S. L. Friedman
semanticscholar +1 more source
Biomedicines, 2021 Hepatic fibrosis is the primary predictor of mortality in patients with non-alcoholic steatohepatitis (NASH). In this process, the activated hepatic stellate cells (HSCs) constitute the principal cells responsible for the deposition of a fibrous ...
Alexandra Zisser +2 more
semanticscholar +1 more source
Cell Proliferation, 2021 Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC activation and ECM accumulation. The underlying mechanism remains unclear.
Siyu Yuan +7 more
semanticscholar +1 more source
Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation
Biomedicines, 2021 Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix (ECM) in the liver resulting from the persistent liver injury and wound-healing reaction induced by various insults.
Yu-Xin Yan +3 more
semanticscholar +1 more source