Results 11 to 20 of about 205,561 (359)

Initiation of hepatic stellate cell activation extends into chronic liver disease

Cell Death and Disease, 2021
Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation.
Vincent De Smet, N. Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, G. Halder, S. Verhulst, I. Mannaerts, L. V. van Grunsven   +7 more
semanticscholar   +1 more source

The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis

Cell Death and Disease, 2023
Hepatic stellate cell is one of the major nonparenchymal cell types in liver. It has been proved the hepatic stellate cells are activated upon liver injury and produce excessive extracellular matrix to induce liver fibrosis.
Mengfan Zhang, Yang Jing, Wenze Xu, Xiaojing Shi, Wenguang Zhang, Pengfei Chen, Xiaocang Cao, Xinwei Han, Xuhua Duan, Jianzhuang Ren   +9 more
doaj   +1 more source

FBP1 loss disrupts liver metabolism and promotes tumourigenesis through a hepatic stellate cell senescence secretome

Nature Cell Biology, 2020
The crosstalk between deregulated hepatocyte metabolism and cells within the tumour microenvironment, as well as the consequent effects on liver tumorigenesis, are not completely understood. We show here that hepatocyte-specific loss of the gluconeogenic
Fuming Li, Peiwei Huangyang, Peiwei Huangyang, Michelle Burrows, Kathy Guo, Kathy Guo, Romain Riscal, Jason Godfrey, Kyoung Eun Lee, Kyoung Eun Lee, Nan Lin, Pearl Lee, I. Blair, B. Keith, B. Keith, Bo Li, M. Simon   +16 more
semanticscholar   +2 more sources

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

JCI Insight, 2021
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion ...
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas   +10 more
doaj   +1 more source

Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation. [PDF]

PLoS ONE, 2012
Activation of hepatic stellate cells has been recognized as one of the first steps in liver injury and repair. During activation, hepatic stellate cells transform into myofibroblasts with concomitant loss of their lipid droplets (LDs) and production of ...
Nicole Testerink, Mokrish Ajat, Martin Houweling, Jos F Brouwers, Vishnu V Pully, Henk-Jan van Manen, Cees Otto, J Bernd Helms, Arie B Vaandrager   +8 more
doaj   +1 more source

Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells

Biomolecules, 2022
Hepatic steatosis and chronic hepatocyte damage ultimately lead to liver fibrosis. Key pathophysiological steps are the activation and transdifferentiation of hepatic stellate cells.
Maria Teresa Koenen, Elisa Fabiana Brandt, Dawid Marcin Kaczor, Tim Caspers, Alexandra Catharina Anna Heinzmann, Petra Fischer, Daniel Heinrichs, Theresa Hildegard Wirtz, Christian Trautwein, Rory R Koenen, Marie-Luise Berres   +10 more
doaj   +1 more source

Liver fibrosis is driven by protease‐activated receptor‐1 expressed by hepatic stellate cells in experimental chronic liver injury

Research and Practice in Thrombosis and Haemostasis, 2020
Background Blood coagulation protease activity is proposed to drive hepatic fibrosis through activation of protease‐activated receptors (PARs). Whole‐body PAR‐1 deficiency reduces experimental hepatic fibrosis, and in vitro studies suggest a potential ...
Lauren G. Poole, Asmita Pant, Holly M. Cline‐Fedewa, Kurt J. Williams, Bryan L. Copple, Joseph S. Palumbo, James P. Luyendyk   +6 more
doaj   +1 more source

NOX as a Therapeutic Target in Liver Disease

Antioxidants, 2022
The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or NOX) plays a critical role in the inflammatory response and fibrosis in several organs such as the lungs, pancreas, kidney, liver, and heart. In the liver, NOXs contribute,
Deyamira Matuz-Mares, Héctor Vázquez-Meza, María Magdalena Vilchis-Landeros   +2 more
doaj   +1 more source

Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Nonalcoholic fatty liver disease (NAFLD) is a fast growing, chronic liver disease affecting ∼25% of the global population. Nonalcoholic fatty liver disease severity ranges from the less severe simple hepatic steatosis to the more advanced nonalcoholic ...
Leke Wiering, Pallavi Subramanian, Linda Hammerich   +2 more
doaj   +1 more source

Hepatic Stellate Cell–Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis

Seminars in liver disease (Print), 2020
Chronic liver injury due to viral hepatitis, alcohol abuse, and metabolic disorders is a worldwide health concern. Insufficient treatment of chronic liver injury leads to fibrosis, causing liver dysfunction and carcinogenesis.
M. Matsuda, E. Seki
semanticscholar   +1 more source