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Hepatitis Delta Virus RNA Replication
Viruses, 2009 Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism.
Chung-Hsin Tseng, Michael M. C. Lai
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Immunological response of Hepatitis B Virus Surface Antigen in HBV Mono and HBV/HDV Co-infection [PDF]
Pakistan Journal of Medicine and Dentistry, 2021 Hepatitis B virus (HBV) can evolve under selection pressure exerted by drugs and host immunity, resulting in the accumulation of escape mutations that can affect the drug or the immune activity.
Mehwish Sajjad +3 more
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Chronic Hepatitis B in the United States: Current Landscape, Unmet Needs and Future Directions. [PDF]
J Viral HepatABSTRACT Chronic hepatitis B (CHB) infection represents a major public health challenge in the US, with substantial unmet needs related to timely diagnosis, treatment, monitoring and disease management. This narrative review explores the CHB landscape in the US, including gaps in patient care, the evolving therapeutic landscape, the clinical utility of
Cohen C, Esteban JP, Bobde S, Wong RJ.
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A novel form of hepatitis delta antigen [PDF]
Journal of Virology, 1996 Hepatitis delta virus (HDV) is known to express a protein termed the small delta antigen, a structural protein which is also essential for genome replication. During replication, posttranscriptional RNA editing specifically modifies some of the HDV RNA, leading to the production of an elongated form of the delta antigen, the large form, which is ...
V V, Bichko, Y E, Khudyakov, J M, Taylor
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Phosphorylation of the hepatitis delta virus antigens [PDF]
Journal of Virology, 1997 We used two-dimensional electrophoresis (nonequilibrium pH gradient electrophoresis followed by sodium dodecyl sulfate-10% polyacrylamide gel electrophoresis) coupled with 32P labeling and immunoblotting detection with 125I-protein A to detect and quantitate phosphorylation of the large and small forms of the delta antigen (deltaAg-L and deltaAg-S ...
V, Bichko, S, Barik, J, Taylor
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Hepatitis Delta Antigen Mediates the Nuclear Import of Hepatitis Delta Virus RNA [PDF]
Journal of Virology, 1998 ABSTRACT Hepatitis delta virus (HDV) RNA replicates in the nuclei of virus-infected cells. The mechanism of nuclear import of HDV RNA is so far unknown. Using a fluorescein-labeled HDV RNA introduced into partially permeabilized HeLa cells, we found that HDV RNA accumulated only in the cytoplasm.
H C, Chou +3 more
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Characterization of hepatitis delta antigen: specific binding to hepatitis delta virus RNA [PDF]
Journal of Virology, 1990 It has previously been shown that human hepatitis virus delta antigen has an RNA-binding activity (Chang et al., J. Virol. 62:2403-2410, 1988). In the present study, the specificity of such an RNA-protein interaction was demonstrated by expressing various domains of the delta antigen in Escherichia coli as TrpE fusion proteins and testing their RNA ...
J H, Lin +4 more
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Hepatitis delta antigens enhance the ribozyme activities of hepatitis delta virus RNA in vivo [PDF]
Journal of Virology, 1996 The mechanism of regulation for the ribozyme activity of hepatitis delta virus (HDV) RNA in infected cells is unknown. Previously, we developed a direct assay capable of detecting the ribozyme activity of HDV dimer or trimer RNAs in vivo (K.-S. Jeng, A. Daniel, and M. M. C. Lai, J. Virol, 70:2403-2410, 1996).
K S, Jeng, P Y, Su, M M, Lai
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Genotype-Specific Complementation of Hepatitis Delta Virus RNA Replication by Hepatitis Delta Antigen [PDF]
Journal of Virology, 1998 ABSTRACT Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and about 10 to 15% among isolates of the same genotype.
J L, Casey, J L, Gerin
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HLA-A*11:01 Identifies Patients at Risk for Persistent Viraemia and Advanced Fibrosis in HDV Infection. [PDF]
Aliment Pharmacol TherThe HLA‐A*11:01 allele is associated with persistent viraemia and advanced liver fibrosis in HDV infection. HLA‐A*11:01 carriers exhibit a reduced T‐cell repertoire, suggesting a narrower T‐cell response to the infection. ABSTRACT Background Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, with highly heterogeneous ...
Cortese MF +11 more
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