Results 21 to 30 of about 1,159,378 (230)

Clinical and virological heterogeneity of hepatitis delta in different regions world‐wide: The Hepatitis Delta International Network (HDIN)

, 2017
Background & Aims: Chronic hepatitis D (delta) is a major global health burden. Clinical and virological characteristics of patients with hepatitis D virus (HDV) infection and treatment approaches in different regions world-wide are poorly defined ...
Michael P. Manns, Heiner Wedemeyer, Svenja Hardtke, Niro, Grazia A., Peter Ferenci, Naranjargal Dashdorj, Anika Wranke, Markus Cornberg, Maria Buti, Lobato, Cirley, Rizzetto, Mario, Adriana Motoc, Zaigham Abbas, Ceausu, Emanoil, Wranke, Anika, Ferenci, Peter, Vanwolleghem, Thomas, George N. Dalekos, Grazia A. Niro, Yurdaydin, Cihan, Tonya Hayden, Lubna, Farheen, Mario Rizzetto, Parana, Raymundo, Pinheiro Borzacov, Lourdes M., null null, Thomas Vanwolleghem, Emanoil Ceausu, Abbas, Minaam, Raymundo Parana, Minaam Abbas, Cihan Yurdaydin, Buti, Maria, Ingiliz, Patrick, Lourdes M. Pinheiro Borzacov, Borzacov, Lourdes M. Pinheiro, Dalekos, George N., Patrick Ingiliz, Farheen Lubna, Hardtke, Svenja, Wedemeyer, Heiner, Cirley Lobato, Hamid, Saeed, Turcanu, Adela, Hayden, Tonya, Motoc, Adriana, Dashdorj, Naranjargal, Adela Turcanu, Cornberg, Markus, Saeed Hamid, Manns, Michael P., Abbas, Zaigham, Wranke A., Pinheiro Borzacov L.M., Parana R., Lobato C., Hamid S., Ceausu E., Dalekos G.N., Rizzetto M., Turcanu A., Niro G.A., Lubna F., Abbas M., Ingiliz P., Buti M., Ferenci P., Vanwolleghem T., Hayden T., Dashdorj N., Motoc A., Cornberg M., Abbas Z., Yurdaydin C., Manns M.P., Wedemeyer H., Hardtke S., Serrano B., Wöbse M., Heidrich B., Muche M., Gatselis N., Zachou K., Ho E., Smedile A., Fontana R., Gish R., Obretin D., Stern R., the Hepatitis Delta International Network, the Hepatitis Delta International Network   +53 more
core   +2 more sources

Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes

Cell Reports Medicine, 2020
Summary: Hepatitis delta virus (HDV) requires hepatitis B virus (HBV) to complete its infection cycle and causes severe hepatitis, with limited therapeutic options.
Christine Y.L. Tham, Janine Kah, Anthony T. Tan, Tassilo Volz, Adeline Chia, Katja Giersch, Yvonne Ladiges, Alessandro Loglio, Marta Borghi, Camille Sureau, Pietro Lampertico, Marc Lütgehetmann, Maura Dandri, Antonio Bertoletti   +13 more
doaj   +1 more source

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Nature Communications, 2020
Histone mimicry of viral components is a strategy to subvert host factors for virus replication. Here, the authors show that an acetylated histone-like motif of the small Hepatitis Delta Antigen (S-HDAg) interacts with the chromatin remodeler BAZ2B to ...
Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Camille Sureau, Susanne Müller, Dulce Alfaiate, Francesca Guerrieri, Apirat Chaikuad, Martin Schröder, Philippe Merle, Massimo Levrero, Paul Dény   +10 more
doaj   +1 more source

Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin

Frontiers in Microbiology, 2021
Hepatitis delta virus (HDV) is a human pathogen, and the only known species in the genus Deltavirus. HDV is a satellite virus and depends on the hepatitis B virus (HBV) for packaging, release, and transmission.
Hans J. Netter, Hans J. Netter, Marilou H. Barrios, Marilou H. Barrios, Margaret Littlejohn, Lilly K. W. Yuen   +5 more
doaj   +1 more source

Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection [PDF]

, 2002
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in
Antonio Bertoletti, Brown, D., Dusheiko, G., Geoff Dusheiko, Williams, R., George J.M. Webster, Webster, G.J.M., David Brown, Mala K. Maini, Stephanie Reignat, King, A., Suranjith L. Seneviratne, Roger Williams, Bertoletti, A., Reignat, S., Maini, M.K., Graham S. Ogg, Abigail King, Ogg, G.S., Seneviratne, S.L.   +19 more
core   +1 more source

ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ)

Архивъ внутренней медицины, 2014
A significant part of liver disease, once considered the result of infection by hepatitis B virus (HBV), are the result of infection HBV, and hepatitis delta virus (HDV).
Т. В. Кожанова, Л. Ю. Ильченко, М. И. Михайлов   +2 more
doaj   +1 more source

A Divergent Hepatitis D-Like Agent in Birds

Viruses, 2018
Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry.
Michelle Wille, Hans J. Netter, Margaret Littlejohn, Lilly Yuen, Mang Shi, John-Sebastian Eden, Marcel Klaassen, Edward C. Holmes, Aeron C. Hurt   +8 more
doaj   +1 more source

Comprehensive Analysis of Hepatitis Delta Virus Assembly Determinants According to Genotypes: Lessons From a Study of 526 Hepatitis Delta Virus Clinical Strains

Frontiers in Microbiology, 2021
Human hepatitis Delta virus (HDV) infection is associated to the most severe viral hepatic disease, including severe acute liver decompensation and progression to cirrhosis, and hepatocellular carcinoma. HDV is a satellite of hepatitis B virus (HBV) that
Athenaïs Gerber, Athenaïs Gerber, Frédéric Le Gal, Frédéric Le Gal, Frédéric Le Gal, Samira Dziri, Samira Dziri, Chakib Alloui, Chakib Alloui, Chakib Alloui, Dominique Roulot, Dominique Roulot, Dominique Roulot, Paul Dény, Paul Dény, Camille Sureau, Ségolène Brichler, Ségolène Brichler, Ségolène Brichler, Emmanuel Gordien, Emmanuel Gordien, Emmanuel Gordien   +21 more
doaj   +1 more source

The large form of hepatitis delta antigen is crucial for assembly of hepatitis delta virus. [PDF]

Proceedings of the National Academy of Sciences, 1991
The virions of hepatitis delta virus (HDV) contain two species of HDV-specific protein, a large and a small form of hepatitis delta antigen (HDAg). We examined the role of individual HDAgs in virion assembly in cotransfection experiments. First, we constructed a replication-competent HDV mutant expressing only the small HDAg.
F L, Chang, P J, Chen, S J, Tu, C J, Wang, D S, Chen   +4 more
openaire   +2 more sources

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease [PDF]

, 2012
Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to
Chopra, A., Gordon, A, Scott Bowden, Pfafferott, K, Desmond, P.V., Ian R. James, Revill, P.A., Chopra, A, Mallal, SA, Silvana Gaudieri, Anna Ayres, Lewin, S.R., Thompson, AJ, Desmond, C.P., Jennifer Audsley, James, IR, Locarnini, SA, Stephen A. Locarnini, Sharon R. Lewin, James, I.R., Locarnini, S.A., Chivers, S., Christopher P. Desmond, Desmond, PV, Thompson, A.J., Stuart K. Roberts, Audsley, J, Revill, PA, Lau, GK, Gaudieri, S, Gaudieri, S., Audsley, J., Day, C, Caroline Day, Ayres, A, Day, C., Paul V. Desmond, Pfafferott, K., Gordon, A., Roberts, SK, Peter A. Revill, Alexander J. Thompson, Ayres, A., Desmond, CP, Sarah Chivers, Katja Pfafferott, Bowden, S., George K. Lau, Simon A. Mallal, Lewinb, SR, Lau, G.K., Roberts, S. K., Abha Chopra, Bowden, S, Mallal, S.A., Adam Gordon, Chivers, S   +56 more
core   +1 more source