A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease [PDF]
Biochemistry Research International, 2014 Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis.
Rui Liu +8 more
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Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha. [PDF]
PLoS ONE, 2014 Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell lines occur at a much lower level than their ...
Tsai-Shin Chiang +4 more
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Gliclazide challenge testing as an alternative diagnostic tool for hepatocyte nuclear factor-1-alpha maturity onset diabetes of the young [PDF]
European Journal of Case Reports in Internal MedicineBackground: Hepatocyte nuclear factor-1-alpha monogenic diabetes (HNF1-alpha DM), formerly known as maturity-onset diabetes of the young type 3 (MODY 3), is often misdiagnosed as type 1 or type 2 diabetes. In regions where genetic testing is unavailable,
Sunjay Pandya +6 more
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Genetic Study of Hepatocyte Nuclear Factor 1 Alpha Variants in Development of Early-Onset Diabetes Type 2 and Maturity-Onset Diabetes of the Young 3 in Iran [PDF]
Advanced Biomedical Research, 2019 Background: Maturity-onset diabetes of the young (MODY) is a clinically and genetically heterogeneous group of diabetes characterized by noninsulin-dependent, autosomal-dominant disorder with strong familial history, early age of onset, and pancreatic ...
Aliasgar Mohammadi +7 more
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Identification of a novel hepatocyte nuclear factor-1 alpha (HNF1A) variant in maturity onset diabetes of the young type 3 (HNF1A-MODY) [PDF]
Endocrinology, Diabetes & Metabolism Case Reports, 2022 We identified an adolescent young woman with new-onset diabetes. Due to suspicious family history, she underwent genetic testing for common monogenic diabetes (MODY) genes.
Megha Verma, Stephen I Stone
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Hepatocyte nuclear factor 1 alpha influences pancreatic cancer growth and metastasis. [PDF]
Sci Rep, 2020 AbstractHepatocyte nuclear factor 1 homeobox alpha (HNF1α) is a transcription factor involved in endodermal organogenesis and pancreatic precursor cell differentiation and development. Earlier studies have reported a role for HNF1α in pancreatic ductal adenocarcinoma (PDAC) but it is controversial.
Subramani R +10 more
europepmc +5 more sources
Animal, 2010 The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY).
B. Fan, Z.-Q. Du, M.F. Rothschild
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Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans. [PDF]
PLoS ONE, 2014 Glomerular nodular lesions, known as Kimmelstiel-Wilson nodules, are a pathological hallmark of progressive human diabetic nephropathy. We have induced severe diabetes in pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha (HNF1α ...
Satoshi Hara +4 more
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Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid[S] [PDF]
Journal of Lipid Research, 2019 All-trans retinoic acid (atRA) is used to treat certain cancers and dermatologic diseases. A common adverse effect of atRA is hypercholesterolemia; cytochrome P450 (CYP) 7A repression is suggested as a driver. However, the underlying molecular mechanisms
Kyoung-Jae Won +2 more
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MODY: Strategies for a unique form of diabetes [PDF]
Journal of Education and Health PromotionMaturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
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