Results 1 to 10 of about 334,700 (354)

Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha. [PDF]

PLoS One, 2014
Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell lines occur at a much lower level than their corresponding activities in primary hepatocytes, and thus these cell lines may not accurately predict drug ...
Chiang TS, Yang KC, Chiou LL, Huang GT, Lee HS.   +4 more
europepmc   +9 more sources

A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease. [PDF]

Biochem Res Int, 2014
Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese ...
Liu R, Liu H, Gu H, Teng X, Nie Y, Zhou Z, Zhao Y, Hu S, Zheng Z.   +8 more
europepmc   +9 more sources

Identification of a novel hepatocyte nuclear factor-1 alpha (HNF1A) variant in maturity onset diabetes of the young type 3 (HNF1A-MODY). [PDF]

Endocrinol Diabetes Metab Case Rep, 2022
Summary We identified an adolescent young woman with new-onset diabetes. Due to suspicious family history, she underwent genetic testing for common monogenic diabetes (MODY) genes. We discovered that she and her father carry a novel variant of uncertain significance in the HNF1A gene.
Verma M, Stone SI.
europepmc   +8 more sources

Hepatocyte nuclear factor 1 alpha influences pancreatic cancer growth and metastasis. [PDF]

Sci Rep, 2020
AbstractHepatocyte nuclear factor 1 homeobox alpha (HNF1α) is a transcription factor involved in endodermal organogenesis and pancreatic precursor cell differentiation and development. Earlier studies have reported a role for HNF1α in pancreatic ductal adenocarcinoma (PDAC) but it is controversial.
Subramani R, Medel J, Flores K, Perry C, Galvez A, Sandoval M, Rivera S, Pedroza DA, Penner E, Chitti M, Lakshmanaswamy R.   +10 more
europepmc   +6 more sources

Hepatocellular Adenoma With Hepatocyte Nuclear Factor-1 Alpha (HNF-1α) Mutation: A Case Report. [PDF]

Cureus
Hepatocellular adenoma (HCA) is an uncommon benign liver tumor that exhibits a variety of subtypes, each distinguished by unique molecular alterations. This case report describes a 43-year-old man with a history of alcoholism who presented with stomach pain.
Moliya P, Al-Obaidi H, Harb H, Moliya U, Asit M.   +4 more
europepmc   +6 more sources

Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young [PDF]

Diabetologia, 2002
Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent approximately 10% of reported HNF-1 alpha mutations.
M. P. Bulman, Sian Ellard, T. Hansen, W. F. Kelly, Maggie Shepherd, Andrew T. Hattersley, Lorna W. Harries   +6 more
openaire   +5 more sources

Regulation of the gene for human dipeptidyl peptidase IV by hepatocyte nuclear factor 1α [PDF]

Biochemical Journal, 1999
Hepatocyte nuclear factor 1 was identified as the transcription factor binding to a 20 bp (-150 to -131) region of the gene for human dipeptidyl peptidase IV, which has been shown to be important for the expression of dipeptidyl peptidase IV in the human intestinal and hepatic epithelial cell lines Caco-2 and HepG2.
Roger H. Erickson, Roger H. Erickson, James R. Gum, James R. Gum, Craig D. Lotterman, Craig D. Lotterman, Young S. Kim, Young S. Kim, Roy S. Lai, Roy S. Lai, James W. Hicks, James W. Hicks   +11 more
openaire   +4 more sources

Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver [PDF]

The Pharmacogenomics Journal, 2007
Experimental evidence suggests HNF1alpha regulates UGT expression. This study investigates (1) whether the variability in HNF1alpha expression is associated with the variability in UGT1A1, UGT1A9 and UGT2B7 expression in human livers and (2) the functionality of 12 HNF1alpha variants using mRNA expression as phenotype.
Federico Innocenti, Soma Das, Wanqing Liu, Wei Zhang, Mark J. Ratain, Peixian Chen, Jacqueline Ramírez, Snezana Mirkov   +7 more
openaire   +4 more sources

Hepatocyte Nuclear Factor-1α Gene Mutations and Diabetes in Norway [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2003
Mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene cause maturity-onset diabetes of the young (MODY), type 3. To estimate the prevalence of MODY3 in Norwegian diabetic pedigrees, we screened a total of 130 families for HNF-1 alpha mutations; 42 families with clinical MODY, 75 with suspected MODY, and 13 pedigrees with multiplex type 1 ...
Pål R. Njølstad, Pål R. Njølstad, Anders Molven, Per Medbøe Thorsby, Jørn V. Sagen, Lise Bjørkhaug, Oddmund Søvik   +6 more
openaire   +3 more sources

Metabolomic analysis of the Hepatocyte Nuclear Factor 1 Alpha knockout mouse

The FASEB Journal, 2010
Genomic mutations in the transcription factor hepatocyte nuclear factor 1 alpha (HNF1α) result in maturity‐onset diabetes of the young type 3 (MODY3), a form of non‐insulin dependent diabetes mellitus (NIDDM). In addition, Hnf1α was identified as a critical factor in the expression of many transporters of the liver, intestine, and kidney.
Andrew D. Patterson, Kristopher W. Krausz, Frank J. Gonzalez, Jessica A. Bonzo   +3 more
openaire   +1 more source