Results 91 to 100 of about 334,700 (354)

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]

, 2016
Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A., Berasain, Carmen, Brozzetti, Stefania, Calvisi, Diego F., Daino, Lucia, Demartis, Maria I., Feo, Claudio F., Feo, Francesco, Latte, Gavinella, Pascale, Rosa M., Porcu, Alberto, Seddaiu, Maria A., Simile, Maria M., Tomasi, Maria L.   +13 more
core   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

STAT3 signaling pathway plays importantly genetic and functional roles in HCV infection

Molecular Genetics & Genomic Medicine, 2019
Background Hepatitis C virus (HCV) infection is an extensive health problem, which leads to serious liver diseases. Host genetic polymorphisms were associated with HCV infection, progression, and treatment effect of patients.
Yuzhu Song, Xianyao Yang, Yunsong Shen, Yiqian Wang, Xueshan Xia, A‐Mei Zhang   +5 more
doaj   +1 more source

Nonlinear preferential rewiring in fixed-size networks as a diffusion process [PDF]

Physical Review E 79, 050104(R) (2009), 2009
We present an evolving network model in which the total numbers of nodes and edges are conserved, but in which edges are continuously rewired according to nonlinear preferential detachment and reattachment. Assuming power-law kernels with exponents alpha and beta, the stationary states the degree distributions evolve towards exhibit a second order ...
arxiv   +1 more source

An epistatic mini-circuitry between the transcription factors Snail and HNF4a controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs [PDF]

, 2012
Preservation of the epithelial state involves the stable repression of EMT program while maintenance of the stem compartment requires the inhibition of differentiation processes.
AMICONE, Laura, CICCHINI, Carla, Conigliaro A., Cozzolino A., Garibaldi F., Grassi G., MARCHETTI, ALESSANDRA, Santangelo L., TRIPODI, Marco   +8 more
core   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Hepatic Differentiation of Marmoset Embryonic Stem Cells and Functional Characterization of ESC-Derived Hepatocyte-Like Cells

Hepatic Medicine: Evidence and Research, 2020
Rajagopal N Aravalli,1 Daniel P Collins,2 Joel H Hapke,2 Andrew T Crane,3 Clifford J Steer4,5 1Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA; 2Cytomedical Design Group LLC, St. Paul, MN 55127, USA;
Aravalli RN, Collins DP, Hapke JH, Crane AT, Steer CJ   +4 more
doaj  

The hepatocyte nuclear factor 1 homeobox A (HNF1A) gene polymorphism and AFP serum levels in Egyptian HCC patients

Egyptian Liver Journal
Hepatocyte nuclear factors were first identified as liver-enriched transcription factors that might participate in various activities related to the transcription of genes unique to the liver.
Hanan M. Bedair, Ibrahim El Tantawy El Sayed, O. Hendy, Mohmed Abdel-Samiee, Islam Abd El Hamid El Sayad, Sally S. Mandour   +5 more
semanticscholar   +1 more source