Results 111 to 120 of about 281,999 (311)

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Migration through host cells activates Plasmodium sporozoites for infection.

, 2002
Plasmodium sporozoites, the infective stage of the malaria parasite transmitted by mosquitoes, migrate through several hepatocytes before infecting a final one. Migration through hepatocytes occurs by breaching their plasma membranes, and final infection
Hafalla, Julius CR, Rodriguez, Ana, Ana Rodriguez, Mota, Maria M, Julius C.R. Hafalla, Maria M. Mota   +5 more
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

"Human hepatocytes are more resistent than rat hepatocytes to anoxia-reoxygenation injury".

, 1993
We performed this study to determine whether perfused isolated human and rat hepatocytes have different sensitivities to anoxia-reoxygenation injury. Oxygen free radicals were detected by lucigenin-enhanced chemiluminescence.
VANTHIEL, DH, BORLE, AB, GASBARRINI, A, A. GASBARRINI, AND D.H. VAN THIEL, P. CARACENI, DISILVIO, M, BARTOLI, FABIO, AND D.H. VANTHIEL, A.B. BORLE, CARACENI, P, E. ROSEMBLUM, NUSSLER, A, BARTOLI, F, A. NUSSLER   +14 more
core   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

Viruses, 2016
Chronic hepatitis B virus (HBV) and hepatitis D virus (HDV) infections are major causes of liver disease and hepatocellular carcinoma worldwide. Despite the presence of an efficient preventive vaccine, more than 250 million patients are chronically ...
Eloi R. Verrier, Che C. Colpitts, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert   +4 more
doaj   +1 more source

BM-derived hepatocytes emerged from fusion between donor BM-derived myelomonocytic cells and host hepatocytes.

, 2014
(A) Donor-derived hepatocyte measurements from EGFP-BMT (top), C3H-BMT (middle), and rat-BMT mice (bottom). Gated donor-derived hepatocytes mostly expressed CD45, and the same hepatocytes were partially positive for recipient MHC class I antigen.
Rui Sun (177521), Xiang Gao (4077), Ziping Qi (626338), Haiming Wei (63665), Zhigang Tian (63666), Xin Wang (91924), Xuefu Wang (626339), Lu Li (14069), Jian Zhang (1682)   +8 more
core   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Induction of cytochrome P450 enzymes in primary equine hepatocytes culture

, 2013
Cytochrome P450 enzymes (CYPs) are responsible for the oxidative metabolism of a wide variety of substances including the majority of drugs. An induction or inhibition of their metabolic activity can therefore change the elimination of drugs from the ...
Stefanski, A
core  

The immobilization of hepatocytes on 24 nm-sized gold colloid for enhanced hepatocytes proliferation

, 2004
Bioartificial liver and hepatocyte transplantation is anticipated to supply a temporary metabolic support for candidates of liver transplantation or for patients with fulminant liver failure.
Chen, HY, Chen, Z, Sa, RX, Yuan, SS, Yu, AM, Gu, HY, Ding, YT   +6 more
core   +1 more source