Results 221 to 230 of about 628,453 (389)

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Hepatocyte-hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications. [PDF]

Hepatol Commun
Wang Z, Cao Z, Dong Y, Hong Y, Zuo L, Wang H.   +5 more
europepmc   +1 more source

MORPHOMETRICAL ANALYSIS OF LIVER HEPATOCYTE IN RABBITS TREATED WITH NANDROLONE DECANOATE: PART TWO

, 2009
Mohammed Taib Tahir, Rand A. Hasso, Ayad A. AL-Sarraj   +2 more
openalex   +1 more source

Protective effects of ZIP8 on Toxoplasma gondii-induced acute hepatocyte injury in mice

, 2022
Yanling Wang, Chong Wang, He Chen, Yuan Zhang, Nannan Gao, Yiran Yu, Yien Xing, Linding Xie, Zhongxin Wang, Yihong Cai   +9 more
openalex   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Expression and function of CYP enzymes and hepatobiliary transporters in an improved long-term sandwich culture hepatocyte model. [PDF]

Sci Rep
Pacsuta J, Bárány N, Kiszelák K, Csíkvári O, Mártonné Tóth B, Jemnitz K, Gáborik Z.   +6 more
europepmc   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

Iron-related intercellular communication in the liver: Main players and mechanisms. [PDF]

Eur J Clin Invest
Fonseca Ó, Oliveira PJ, Muckenthaler MU, Moreira AC, Gomes MS.   +4 more
europepmc   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

<i>MAP3K7CL</i> Inhibits the Inflammatory Responses in Goose Fatty Liver. [PDF]

J Poult Sci
Zhao M, Lv M, Li J, Fan X, Liu L, Gong D, Zhang Y.   +6 more
europepmc   +1 more source