Results 241 to 250 of about 411,384 (307)

Surgery for metabolic liver disease [PDF]

, 1986
Starzl, TE
core  

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses. [PDF]

EMBO J
Cui W, Li Q, Wei J, Zhou T, Zhu H, Huang D, Wang S, Gao J, Zhou R, Sun Z, Ruan H, Lo LJ, Tao T, Chen J, Peng J, Shi H.   +15 more
europepmc   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres, Justyna Wozniak, Hannah Fölsch, Anja Knueppel‐Ruppert, Verena Graeff, Andrea Kriegisch‐Stumpf, Harald Dormann, Julia C. Stingl, Katja S. Just   +8 more
wiley   +1 more source

Immune cells in liver injury: from pathogenic mechanisms to immunotherapy. [PDF]

Front Immunol
Liao H, Zhang J, Zhang J, Chen Y, Chen X, Meng Y, Chen J.   +6 more
europepmc   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Supplementation of L-aspartate corrects MASLD and MASH in mice by inhibiting platelet-hepatocyte interaction-mediated mitochondrial fragmentation via the ATP-P2X7-NEK7-DRP1 axis. [PDF]

Exp Mol Med
Cao WJ, Su R, Fu HL, Wu JJ, Huang LS, Liu FF, Liu J, Jiang ZP, Xu CJ, Rao Y, Huang L.   +10 more
europepmc   +1 more source

Single cell multiomic landscape reveals gene programs driving lipid droplet heterogeneity in hepatic steatosis. [PDF]

Sci Rep
Sehrawat TS, Cooper SA, Navarro-Corcuera A, Schulze RJ, Liu M, Yaqoob U, Yeon Y, Yoon S, Noh YK, Meroueh C, Ahn JC, Argemi J, Bataller RA, McNiven MA, Dehankar MK, Li Y, Lee JH, Casey CA, Faubion WA, Ordog T, Kamath PS, Simonetto DA, Malhi H, Cao S, Shah VH.   +24 more
europepmc   +1 more source

A brief guide to isolating primary hepatocytes from mice. [PDF]

Mol Cells
Song J, An G, Song G, Ying W, Lim W.
europepmc   +1 more source