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Hepatocyte Xenotransplantation
2012Xenotransplantation of hepatocytes is a future promise to treat liver diseases when there is a formal indication for transplantation. In this chapter, we describe techniques for hepatocyte xenotransplantation. The process was divided into three main steps: hepatocyte isolation, transplantation, and identification of donor cells in the recipient.
Katia R F, Lima-Quaresma +4 more
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Artificial Cells, Blood Substitutes, and Biotechnology, 1999
Homogenized rat hepatocytes, whole hepatocytes and encapsulated hepatocytes were incubated with bilirubin and UDP-glucuronic acid to test their ability to form bilirubin conjugates. Bilirubin monoconjugated and diconjugated were detected in all the three preparations by HPLC analysis.
S, Bruni, T M, Chang
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Homogenized rat hepatocytes, whole hepatocytes and encapsulated hepatocytes were incubated with bilirubin and UDP-glucuronic acid to test their ability to form bilirubin conjugates. Bilirubin monoconjugated and diconjugated were detected in all the three preparations by HPLC analysis.
S, Bruni, T M, Chang
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Metabolism of Asialotranscortin by Hepatocytes and Cortisol Binding to Hepatocytes
Endocrine Research Communications, 1981Binding and catabolism of iodinated human transcortin and asialotranscortin were studied in isolated rat hepatocytes. Human transcortin binding to hepatocytes was very low (less than 3%) while 40-60% of the asialotranscortin bound to the hepatocytes. Asialofetuin inhibited asialotranscortin binding to hepatocytes, producing 50% inhibition of binding at
K L, Hossner, R B, Billiar
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Cryopreservation of Hepatocytes
2014The use of cryopreserved hepatocytes has increased in the last decade due to the improvement of the freezing and thawing methods, and has even achieved acceptance by the US Food and Drug Administration for use in drug metabolizing enzyme induction studies.
Nicola J, Hewitt, Albert P, Li
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2009
Apoptosis has been documented as a frequent hurdle phenomenon that occurs in human hepatocytes during isolation, storage, infusion and after engraftment within the recipient liver parenchyma. Apoptosis is an active form of cell death that involves programmed cellular machineries leading to a progressive self-destruction of the cell.
Mustapha, Najimi +2 more
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Apoptosis has been documented as a frequent hurdle phenomenon that occurs in human hepatocytes during isolation, storage, infusion and after engraftment within the recipient liver parenchyma. Apoptosis is an active form of cell death that involves programmed cellular machineries leading to a progressive self-destruction of the cell.
Mustapha, Najimi +2 more
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Hepatocytes: The powerhouse of biotransformation
The International Journal of Biochemistry & Cell Biology, 2012Liver is the most important organ involved in biotransformation of xenobiotics. Within the main organisational unit, the hepatocyte, is an assembly of enzymes commonly classified as phase I and phase II enzymes. The phase I enzymes principally cytochrome P450 catalyse both oxidative and reductive reactions of a bewildering number of xenobiotics.
Danielle K, Sevior +2 more
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Experientia, 1968
In der normalen und regenerierenden Rattenleber wurden Zentriolen gefunden. In der normalen Leberparenchymzelle erscheinen sie wahrscheinlich als Diplosomen. Haufig werden mehr als 2 Zentriolen in der einzelnen Leberparenchymzelle beobachtet, jedoch gibt es keine Anhaltspunkte fur eine zentriolare Replikation in den normalen Leberparenchymzellen ...
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In der normalen und regenerierenden Rattenleber wurden Zentriolen gefunden. In der normalen Leberparenchymzelle erscheinen sie wahrscheinlich als Diplosomen. Haufig werden mehr als 2 Zentriolen in der einzelnen Leberparenchymzelle beobachtet, jedoch gibt es keine Anhaltspunkte fur eine zentriolare Replikation in den normalen Leberparenchymzellen ...
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Journal of Gastroenterology and Hepatology, 2002
Summary Repopulation of the liver with transplanted cells holds significant promise for developing novel therapies. The liver is a most suitable target for treating a variety of genetic, metabolic and acquired diseases. Liver disease, such as chronic viral hepatitis, constitutes an enormous burden worldwide.
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Summary Repopulation of the liver with transplanted cells holds significant promise for developing novel therapies. The liver is a most suitable target for treating a variety of genetic, metabolic and acquired diseases. Liver disease, such as chronic viral hepatitis, constitutes an enormous burden worldwide.
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1980
The purpose of this paper is not to survey current knowledge on aging of hepatic cells in general, but to summarize some of our own results that are concerned with the age changes in DNA content-based polyploidization of hepatocytes of three kinds of laboratory animals: mouse (1), fish (2), and house shrew (3).
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The purpose of this paper is not to survey current knowledge on aging of hepatic cells in general, but to summarize some of our own results that are concerned with the age changes in DNA content-based polyploidization of hepatocytes of three kinds of laboratory animals: mouse (1), fish (2), and house shrew (3).
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Encapsulation of hepatocytes by SiO2
Transplantation Proceedings, 2000BACKGROUND & AIMS: Hepatobiliary complications occur in inflammatory bowel disease and may be caused by the translocation of intestinal toxins from portal blood into bile through leaky hepatocyte tight junctions. The role of tight junctions in the pathogenesis of hepatobiliary complications in experimental inflammatory bowel disease was ...
MURACA, MAURIZIO +8 more
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