Results 241 to 250 of about 406,566 (292)

Lack of MTTP activity in pluripotent stem cell-derived hepatocytes and cardiomyocytes abolishes apoB secretion and increases cell stress [PDF]

, 2017
et al,, Javaheri, Ali
core   +1 more source

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis. [PDF]

J Biol Chem
Kreft T, Blagotinšek Cokan K, Skubic C, Režen T, Perše M, Wechtersbach K, Kojc N, Jeruc J, Debeljak Ž, Heffer M, Matz-Soja M, Rozman D.   +11 more
europepmc   +1 more source

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source

Three-dimensional reconstruction of a biliary system in a bioengineered liver using decellularized scaffold. [PDF]

Sci Rep
Horie H, Fukumitsu K, Hanabata Y, Karasuyama T, Iwaki K, Munekage F, Makino K, Ito T, Tomofuji K, Kojima H, Ogiso S, Uebayashi EY, Uematsu H, Coppo R, Onuma K, Inoue M, Ishii T, Hatano E.   +17 more
europepmc   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Chicken biliary exosomes ameliorate lipopolysaccharide-induced hepatocyte injury. [PDF]

Sci Rep
Zhao Y, Yang Y, Cheng Z, Wang G.
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Cellular senescence in human liver under normal aging and cancer. [PDF]

Cell Genom
Karpova A, Li X, Peng CW, Gallant KL, Rapp DR, Alligood DM, Houston AJ, Park A, Targino da Costa ALN, Chou WH, Iglesia MD, Herndon JM, Byrnes K, Naser Al Deen N, Lal P, Fang X, Jayasinghe RG, Blatnik JA, Hawkins WG, Sanford DE, Eagon JC, Leigh N, Doyle MBM, Brunt LM, Chapman WC, Panni RZ, Cullinan DR, Davies SR, Guo J, Wyczalkowski MA, Wendl MC, Zhang H, Martin CA, Warner BW, Chheda MG, Stewart SA, Chen F, Fields RC, Ding L.   +38 more
europepmc   +1 more source