Results 241 to 250 of about 628,453 (389)

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

Nature Communications, 2014
A. Mardinoğlu, Rasmus Agren, C. Kampf, A. Asplund, M. Uhlén, J. Nielsen   +5 more
semanticscholar   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Correction: magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling. [PDF]

Acta Pharmacol Sin
Yang YZ, Zhao XJ, Xu HJ, Wang SC, Pan Y, Wang SJ, Xu Q, Jiao RQ, Gu HM, Kong LD.   +9 more
europepmc   +1 more source

Modification of the ATM/ATR directed DNA damage response state with aging and long after hepatocyte senescence induction in vivo

, 2008
Suchismita Panda, Ayman Isbatan, Guy R. Adami   +2 more
openalex   +1 more source

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

NEDD4L knockdown reduced lipid accumulation in non-alcoholic fatty liver disease by promoting the activity of PI3K/AKT signaling pathway. [PDF]

Eur J Med Res
Zhou J, Li W, Chi X, Li D, Yang C, Duan Z.   +5 more
europepmc   +1 more source

Effects of taurolithocholate, a Ca2+-mobilizing agent, on cell Ca2+ in rat hepatocytes, human platelets and neuroblastoma NG108-15 cell line [PDF]

, 1991
Jean‐François Coquil, B Berthon, Nathalie Chomiki, Laurent Combettes, Philippe Jourdon, C D Schteingart, Serge Erlinger, M Claret   +7 more
openalex   +1 more source

Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.

Cell Stem Cell, 2014
Pengyu Huang, Ludi Zhang, Yimeng Gao, Zhiying He, D. Yao, Zhi-tao Wu, Jin Cen, Xiaotao Chen, Changcheng Liu, Yi-Ping Hu, D. Lai, Zhenlei Hu, Li Chen, Ying Zhang, Xin Cheng, Xiao-jun Ma, Guoyu Pan, Xin Wang, Lijian Hui   +18 more
semanticscholar   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

MicroR-15b-5p targets JAK2/STAT3 signaling pathway to regulate glucose and lipid metabolism in primary chicken hepatocytes. [PDF]

Poult Sci
Zeng W, Yang L, Zeng C, Cheng X, Cao P, Xing C, Zhang C, Cao H, Guo X, Hu G, Zhuang Y.   +10 more
europepmc   +1 more source